Ar 2000 imaging scanner

Manufactured by Bioscan

Sourced in Canada

The AR-2000 Imaging Scanner is a laboratory equipment device designed for high-resolution imaging and analysis. It captures detailed images of samples and provides data for further examination and evaluation.

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Lab products found in correlation

Itlc sg glass microfiber chromatography paper, by Agilent Technologies (2 mentions) Ultraflextreme spectrometer, by Bruker (1 mentions) Thermomixer c, by Eppendorf (1 mentions) Sgi0001, by Agilent Technologies (1 mentions)

Spelling variants of this product

AR-2000 (36 citations) AR-2000 radio-TLC Imaging Scanner (18 citations) AR-2000 scanner (3 citations)

3 protocols using ar 2000 imaging scanner

Radiochemical Synthesis and Characterization

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Chemicals and reagents for synthesis were purchased from Sigma-Aldrich and Conjuprobe and used without further purification. ¹⁷⁷Lu[Lu] was produced by the McMaster Nuclear Reactor (MNR, Hamilton, Ontario, Canada) using the ¹⁷⁶Lu (p,γ) reaction and was provided as a solution of [¹⁷⁷Lu]LuCl₃ in 0.01 M HCl. Radio-TLC was performed using a Bioscan AR-2000 imaging scanner (West Vancouver, BC, Canada) on iTLC-SG glass microfiber chromatography paper (SGI0001, Agilent Technologies, Santa Clara, CA, USA) plates using 0.1 M EDTA as the eluent. For each TLC performed, plates were spotted with approximately 2 μL (≈3.7 kBq) and run for 5 min. MALDI data were obtained using a Bruker Ultraflextreme spectrometer (Billerica, MA, USA).

Vito A., Rathmann S., Mercanti N., El-Sayes N., Mossman K, & Valliant J. (2021). Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer. International Journal of Molecular Sciences, 22(9), 4843.

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In vitro Serum Stability of Cu-64 RGDfK Conjugates

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The in vitro serum stabilities of the ⁶⁴Cu-cyclo(RGDfK)
conjugated
compounds were evaluated by incubation with freshly isolated lean
rat serum. Each ⁶⁴Cu-radiolabeled cyclo(RGDfK) conjugated
compound (9 μM, 100 μCi) was mixed with rat serum (100
μL) in a 1.5 mL centrifuge tube. The reaction was incubated
on an Eppendorf ThermoMixer C (Hauppauge, NY) at 37 °C (300 rpm).
Aliquots were withdrawn at 0, 1, 4, 24, and 48 h, and evaluated by
radio-TLC on a BioScan AR-2000 Imaging Scanner (Washington, DC). The
radio-TLC was analyzed on reverse phase C18 silica plates using 1:1
methanol/5% ammonium formate. The reactions were repeated in triplicate.

Li H., Zhou H., Krieger S., Parry J.J., Whittenberg J.J., Desai A.V., Rogers B.E., Kenis P.J, & Reichert D.E. (2014). Triazine-Based Tool Box for Developing Peptidic PET Imaging Probes: Syntheses, Microfluidic Radiolabeling, and Structure–Activity Evaluation. Bioconjugate Chemistry, 25(4), 761-772.

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Stability Assessment of [99mTc]GVs in Plasma

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To determine the stability of [^99mTc]GVs in plasma, samples were prepared following the procedures described above. To assess the purity, a sample of the mixture was taken and spotted on an iTLC-SG glass microfiber chromatography paper (Agilent Technologies, SGI0001) plate and run with a mobile phase of 75 % methanol, 25 % water, and visualized on a Bioscan AR-2000 Imaging Scanner. The purified [^99mTc]GVs (3.4 MBq, 100 μl) was then added to mouse plasma (900 μl) and incubated on a shaker for 120 min at 37 °C. Samples were taken at 2, 5, 10, 20, 60, and 120 min and analyzed for purity by RadioTLC (Suppl. Fig. S2, ESM). At 60 and 120 min, 450 μl samples were taken, and the GV layer was separated from the plasma by centrifugal flotation (400 rcf, 10 min). The activity in the plasma and GV layers was measured using a dose calibrator.

Le Floc’h J., Zlitni A., Bilton H.A., Yin M., Farhadi A., Janzen N.R., Shapiro M.G., Valliant J.F, & Foster F.S. (2018). In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 20(2), 230-239.

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