Caprylocaproyl macrogol 8 glycerides labrasol

OXA was prepared by Laurus Labs (Hyderabad, India). 5-FU, DOCA, ethyl chloroformate, N-methylmorpholine, N^Ɛ-Boc-l-lysine methyl ester hydrochloride (H-Lys(Boc)-OMe·HCl), lithium aluminum hydride (LiAlH₄), trimethylsilyl diazomethane (2 M solution in hexane), ammonium acetate, and formic acid were purchased from Sigma-Aldrich (St Louis, MO, USA). Caprylocaproyl macrogol-8-glycerides (Labrasol), diethylene glycol monoethyl ether (Transcutol P), and propylene glycol monocaprylate (Capryol 90) were obtained from Gattefossé (St Priest, France). Polyethoxylated castor oil (Cremophor EL) was provided by BASF (Ludwigshafen, Germany). Tetrahydrofuran (THF), chloroform, methanol, acetyl chloride, and n-hexane (analytical grade) were obtained from Merck (Kenilworth, NJ, USA). Solvents for high-performance liquid chromatography (HPLC) and atomic absorption spectroscopy were obtained from Merck and Thermo Fisher Scientific (Waltham, MA, USA).

Oxaliplatin (OP) was purchased from Jiangsu Hengrui Medicine Co., Ltd. (Jiangsu Province, China). Caprylocaproyl macrogol-8-glycerides (Labrasol) were obtained from Gattefossé (Saint Priest, France). Polyoxyethylene (160) polyoxypropylene (30) glycol (poloxamer 188, P188) was provided by BASF (Ludwigshafen, Germany). DC, ethyl chloroformate, N-methylmorpholine, N^ε-Boc-l-lysine methyl ester hydrochloride (H-Lys(Boc)-OMe·HCl), lithium aluminum hydride (LiAlH₄), trimethylsilyl diazomethane (2 M solution in hexane), ammonium acetate, and formic acid were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). Solvents for high-performance liquid chromatography (HPLC) and inductively coupled plasma-mass spectroscopy (ICP-MS) analyses were obtained from Merck and Thermo Fisher Scientific (Waltham, MA, USA).