All reactions were carried out in air using commercial-grade starting materials, solvents, and reagents. The progress of all reactions was monitored by thin layer chromatography (TLC, Silver Spring, MD, USA) using commercially available glass silica gel plates (60 Å, F254). The mobile phase was generally a solvent mixture, and the visualization was undertaken using UV light. All NMR spectra were measured on a Varian NMR 500 spectrometer (Palo Alto, CA, USA) at 500 MHz (1H). Chemical shifts are quoted in parts per million (ppm; % relative to a residual solvent peak for 1H). Chromatographic purifications were undertaken using an ISCO purification unit, Combi Flash RF 75 PSI, using Biotage silica gel columns. LC-MS (Shimadzu Mass Directed Liquid Chromatography mass spectrometry, Kyoto, Japan) purity analyses were undertaken using a 5 μm C18 110 Å column.
Nmr 500 spectrometer
Manufactured by Agilent Technologies
Sourced in United States
The NMR 500 spectrometer is a laboratory instrument designed for nuclear magnetic resonance (NMR) spectroscopy. It operates at a magnetic field strength of 500 MHz and is capable of analyzing the molecular structure and properties of chemical samples.
Automatically generated - may contain errors
Lab products found in correlation
3 protocols using nmr 500 spectrometer
1
Characterization of Organic Compounds
2
General Organic Synthesis Procedures
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All reactions were carried out in air unless otherwise stated,
using commercial grade starting materials, solvents, and reagents.
The progress of all reactions was monitored by thin layer chromatography
(TLC) using commercially available glass silica gel plates (60 Å,
F254). The mobile phase was generally a solvent mixture, and the visualization
was undertaken using UV light. Microwave reactions were conducted
in a CEM Discovery microwave reactor. All NMR spectra were measured
on a Varian NMR 500 spectrometer at either 500 MHz (1H)
or 126 MHz (13C). Chemical shifts are quoted in parts per
million (ppm; δ relative to a residual solvent peak for 1H and 13C). Chromatographic purifications were
undertaken using an ISCO purification unit, Combi Flash RF 75 PSI,
using Biotage silica gel columns. LC-MS purity analyses were undertaken
using a 5 μm C18 110 Å column. Percentage purities were
performed using a 30 min method in water/acetonitrile with 0.1% formic
acid (5 min at 5%, 5–95% over 20 min, 5 min at 95%) with the
UV set to 254 nm. All high-resolution mass spectrometry was carried
out at the EPSRC UK National Mass Spectrometry Facility (NMSF), Swansea
University, using a Thermo Scientific LTQ Orbitrap XL spectrometer.
using commercial grade starting materials, solvents, and reagents.
The progress of all reactions was monitored by thin layer chromatography
(TLC) using commercially available glass silica gel plates (60 Å,
F254). The mobile phase was generally a solvent mixture, and the visualization
was undertaken using UV light. Microwave reactions were conducted
in a CEM Discovery microwave reactor. All NMR spectra were measured
on a Varian NMR 500 spectrometer at either 500 MHz (1H)
or 126 MHz (13C). Chemical shifts are quoted in parts per
million (ppm; δ relative to a residual solvent peak for 1H and 13C). Chromatographic purifications were
undertaken using an ISCO purification unit, Combi Flash RF 75 PSI,
using Biotage silica gel columns. LC-MS purity analyses were undertaken
using a 5 μm C18 110 Å column. Percentage purities were
performed using a 30 min method in water/acetonitrile with 0.1% formic
acid (5 min at 5%, 5–95% over 20 min, 5 min at 95%) with the
UV set to 254 nm. All high-resolution mass spectrometry was carried
out at the EPSRC UK National Mass Spectrometry Facility (NMSF), Swansea
University, using a Thermo Scientific LTQ Orbitrap XL spectrometer.
3
Synthesis of Hybrid Agents
Check if the same lab product or an alternative is used in the 5 most similar protocols
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All reactions were carried out in air using commercial grade starting materials, solvents, and reagents. The progress of all reactions was monitored by thin layer chromatography (TLC) using commercially available glass silica gel plates (60 Å, F254). The mobile phase was generally a solvent mixture, and the visualization was undertaken using UV light. All NMR spectra were measured on a Varian NMR 500 spectrometer at 500 MHz (1H). Chemical shifts are quoted in parts per million (ppm; % relative to a residual solvent peak for 1H). Chromatographic purifications were undertaken using an ISCO purification unit, Combi Flash RF 75 PSI, using Biotage silica gel columns. LC-MS purity analyses were undertaken using a 5 μm C18 110 Å column. The synthesis of the hybrid agents is detailed in the ESI.
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