Originpro 2018 software version 9

Promoter sequence analysis was performed with AthaMap tool (http://www.athamap.de). Oligonucleotides were designed and analyzed by IDT OligoAnalyzer (https://eu.idtdna.com/calc/analyzer). Oligonucleotides used in this study are listed in Table S1.
Statistical analyses (one-way and two-way ANOVA, means comparisons by Tukey tests) were performed using the OriginPro 2018 software version 9.5 (OriginLab Corporation, Northampton, MA, USA). In case of one-way ANOVA the differences between means were determined Tukey test or by Duncan’s multiple range test and labeled in all diagrams by different letters. When two-way ANOVA was used, the means comparison were made with Tukey test. Data were processed and in some experiments Diagrams were prepared with MS Excel 14.7.7, and figures were assembled with MS Powerpoint 14.7.7 and Adobe Photoshop CS5.1.

The experiments were carried out with two or three independent biological repetitions, as indicated. Sample numbers are given for each experiment in the corresponding Mat&Methods paragraphs. The data are presented as the mean ± standard error (SE) calculated from the combined data of biological repetitions. Statistical analyses (two-way ANOVA, means comparisons by Bonferroni) were performed using the OriginPro 2018 software version 9.5 (OriginLab Corporation, Northampton, MA, USA). Differences of the mutant from the wild type control were determined by Student’s t-test and the significant differences were represented as follows: * p ≤ 0.1; ** p ≤ 0.01; *** p ≤ 0.001.