Lipo dorsomorphin

Manufactured by Santa Cruz Biotechnology

Sourced in United States

Lipo-Dorsomorphin is a chemical compound that acts as a potent and selective inhibitor of the BMP (Bone Morphogenetic Protein) signaling pathway. It functions by blocking the activity of the BMP type I receptors, ALK2 and ALK3, which are involved in the regulation of various cellular processes.

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Lab products found in correlation

Spectramax i3x, by Molecular Devices (1 mentions)

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Dorsomorphin (9 citations)

2 protocols using lipo dorsomorphin

Targeted Drug Delivery to Brain Using Liposomes

Cited 2 times

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Liposomes (FormuMax) that contain a lipid fluorescent dye, Fluorescein DHPE (Lipo-DHPE), Alpha-NETA (ChemR23 specific inhibitor, Lipo-Alpha-NETA, Santa Cruz Biotechnology) (Graham et al., 2014 (link)), STO-609 (CAMKK2 specific inhibitor, Lipo-STO-609, Santa Cruz Biotechnology) (Cary et al., 2013 (link)) or Dorsomorphin (AMPK specific inhibitor, Lipo-Dorsomorphin, Santa Cruz Biotechnology) (Shi et al., 2017 (link)) were prepared according to the manufacturer’s protocol. Intra-liposomal Alpha-NETA, STO-609 or Dorsomorphin concentration determined by microplate reader system (400nm, SpectraMax i3x, Molecular Devices), was 6 μg/μl 1μg/g (2μl) rat was intracerebroventricularly administered into contralateral ventricle of P6 rats of either sex.

Zhang Y., Xu N., Ding Y., Zhang Y., Li Q., Flores J., Haghighiabyaneh M., Doycheva D., Tang J, & Zhang J.H. (2018). Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats. Brain, behavior, and immunity, 70, 179-193.

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Liposomal Delivery of AMPK and PPARγ Modulators

Cited 1 time

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Liposomes (SKU: F10209D, FormuMax Scientific, Sunnyvale, CA, USA) consisting of lipid fluorescent dye, Lipo-DHPE (Fluorescein DHPE), Lipo-Dorsomorphin (Product No. P5199, Dorsomorphin, AMPK inhibitor, Santa Cruz Biotechnology, Dallas, TX, USA) or Lipo-GW9662 (Product No. M6191, GW9662, PPARγ antagonist, Sigma Aldrich, MO, USA) were prepared according to manufacturer’s protocol as has been previously reported (19 (link)). The final concentration of liposomal Dorsomorphin (6 µg/µl) and GW9662 (12 µg/µl) was assessed using a microplate reader system (400nm, SpectraMax i3x, Molecular Devices, Thermo Fisher Scientific, Waltham, MA, USA).

Xu N., Li X., Weng J., Wei C., He Z., Doycheva D.M., Lenahan C., Tang W., Zhou J., Liu Y., Xu Q., Liu Y., He X., Tang J., Zhang J.H, & Duan C. (2022). Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats. Frontiers in Immunology, 13, 873382.

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