Choline chloride

Manufactured by Daejung Chemicals

Choline chloride is a water-soluble organic compound that serves as a precursor for the biosynthesis of the neurotransmitter acetylcholine. It is commonly used as a nutritional supplement and in various laboratory applications.

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Lab products found in correlation

Sucrose, by Merck Group (2 mentions) Potassium carbonate, by Daejung Chemicals (1 mentions) L arginine, by Merck Group (1 mentions) L phenylalanine, by Merck Group (1 mentions) L tyrosine, by Merck Group (1 mentions) Fructose, by Merck Group (1 mentions) 1 4 dioxane, by Daejung Chemicals (1 mentions)

4 protocols using choline chloride

Continuous Flow Synthesis of Organochlorines

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Chemicals: Choline chloride, phosphoryl oxychloride, potassium carbonate, and celite were purchased from Daejung Chemicals & Metals Co., Ltd., Siheung, Republic of Korea. (R)-(

-

)-3-chloro-1,2-propanediol was purchased from TCI. All other chemicals were purchased from Merck.
Flow system: All parts of the system were manually assembled to customize the continuous flow reactor. Chemyx Fusion 200 syringe pumps were used for reactants injection. Among the system components, shut-off valve, static mixing tee, 4-port 3-way flow-switching valves and unions were purchased from Upchurch Scientific. Gastight borosilicate glass syringes (10 mL and 25 mL volumes) and 1/32″ ID tubing (PTFE) were purchased from Runze Fluid. The product-collecting vials located at the end of the system were 50 mL borosilicate vials, purchased from Samwoo Kurex.

Park J., Lee S., Kim G., Malpani Y.R., Park B.Y, & Hwang Y.J. (2022). Flow Synthesis of L-α-Glycerylphosphorylcholine: Studies on Synthetic Routes Applicable to a Flow Reactor and Optimization of Reaction Conditions. Pharmaceutics, 14(11), 2480.

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Synthesis and Characterization of Choline Chloride Compounds

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The choline chloride (>99.0% w/w) was provided from Daejung. The sucrose (>99.5% w/w), fructose (>99.5% w/w), PEGDME with a molar mass of 250 g mol⁻¹ (>99.0% w/w), l-arginine (>99.0% w/w), l-phenylalanine (>99.0% w/w), and l-tyrosine (>99.0% w/w) were purchased from Merck. All of the materials were utilized without additional purification and also the solutions were prepared with double distilled deionized water. To determine the water content of compounds, the Karl-Fischer technique was utilized.

SÖĞÜTLÜ İ., Saeed S.M., Adil M., Yadav A., Abdulkareem Mahmood E, & Saadh M.J. (2023). Extraction of some essential amino acids using aqueous two-phase systems made by sugar-based deep eutectic solvents. RSC Advances, 13(29), 19674-19681.

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Headspace Analysis of 1,4-Dioxane Compounds

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1,4-Dioxane (99.5%) was a product of Daejung Chemicals & Metals (Siheung-si, Republic of Korea), and 1,4-Dioxane-d8 (2000 μg/mL in methanol), which was used as an internal standard (IS) material, was purchased from Sigma-Aldrich (Saint Louis, MO, USA). Choline bitartrate (98%), choline chloride (99%), polysorbate 60 (≥99.5%), and PEG 600 (≥99.5%), used as bases in the preparation of standard solutions, were products of Daejung Chemicals & Metals. Polysorbate 20 (99%) was purchased from Duksan reagents (Ansan-si, Republic of Korea), and PEG 1000 (≥99.5%) was purchased from Samchun Chemicals (Seoul, Republic of Korea).
For crimp-top headspace analysis, 20 mL vials (TLS-20ML-20-V1002), 0 mm PTFE/white silicone, 3 mm thick septa (TLS-20-SP3004), and 20 mm open-top aluminum crimp caps (10 mm hole) were purchased from Yuil Labtech (Namyangju-si, Korea). For comparisons, a screw-type head space with 20 mL vials (SL.Vi1173) and caps (SL.Vi1176) were purchased from SciLab Korea (Seoul, Republic of Korea).

Kim M.C., Park S.Y., Kwon S.Y., Kim Y.K., Kim Y.I., Seo Y.S., Cho S.M., Shin E.C., Mok J.H, & Lee Y.B. (2023). Application of Static Headspace GC-MS Method for Selective 1,4-Dioxane Detection in Food Additives. Foods, 12(17), 3299.

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Choline Chloride and Drug Solvent Characterization

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The choline chloride (>99 wt%) was provided from Daejung. Merck provided sucrose with a purity greater than 99.5 wt%, as well as PPG with a molar mass of 400 g mol⁻¹. Diclofenac potassium, acetaminophen, and salicylic acid, each with a purity exceeding 99.5 wt%, were sourced from Danna Pharmaceutical Company in Iran. These chemicals were used without further purification. For solution preparation, double-distilled deionized water with a conductivity of 0.055 μS cm⁻¹ was used. The Karl-Fischer technique was employed to determine the water content of the compounds, and additional information about the chemicals is detailed in Table 1.

Ghaffari F., Zafarani-Moattar M.T, & Shekaari H. (2024). Harnessing the power of natural deep eutectic solvents (choline chloride/sucrose) and polypropylene glycol in the formation of aqueous biphasic systems and the application of these systems in drug extraction. RSC Advances, 14(18), 12349-12359.

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