Centaur xp immunoassay system

Manufactured by Siemens

Sourced in United States, Germany

The Centaur XP immunoassay system is a clinical laboratory instrument designed for automated processing of immunoassay tests. It performs a variety of immunoassay tests to measure analytes in biological samples. The system is capable of handling multiple sample types and assay types simultaneously, with high throughput and precision.

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Lab products found in correlation

7600 020 chemical analyzer, by Hitachi (1 mentions) D 10 analyzer, by Bio-Rad (1 mentions) Access 2 immunoassay system, by Beckman Coulter (1 mentions) Dimension vista 1500, by Siemens (1 mentions) 7600 020 autonomic analyzer, by Hitachi (1 mentions)

8 protocols using centaur xp immunoassay system

Metabolic Biomarkers in Fasting and Postprandial States

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All the measurements were made after a 10-h overnight fast. Waist circumference, hip circumference, and blood pressure were measured while participants were barefoot and wearing light clothes after defecation. Blood samples were collected before and 2 h after a fixed breakfast (~300 kcal) for measurement of hemoglobin A1c (HbA1c), fasting lipid profile, fasting and 2-h postprandial plasma glucose (2hPPG), insulin, and C-peptide. Fasting and postprandial plasma glucose levels, lipid concentrations for total cholesterol, triglycerides, and HDL-cholesterol (HDL-c) were measured using an automated enzymatic method (7600-020 Chemical Analyzer, Hitachi, Japan). HbA1c levels were determined by high-performance liquid chromatography (D-10 analyzer, Bio-Rad, Hercules, CA). Fasting and 2-h postprandial plasma insulin and C-peptide were measured by radioimmunoassay (Centaur XP immunoassay system, Siemens Healthcare Diagnostics, New York, NY).
Homoeostasis model assessment (HOMA) was used to estimate basal β-cell function (HOMA-B) and insulin resistance (HOMA-IR). HOMA-B was calculated as [20× fasting insulin (FINS)] / [fasting plasma glucose (FPG)—3.5]. HOMA-IR was calculated as FPG × FINS / 22.5 [14 (link)].

Yang X., Xu W., Zhu Y., Deng H., Tan Y., Zeng L, & Weng J. (2018). Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes. Neuroscience Bulletin, 35(1), 25-33.

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Comprehensive Metabolic Profiling of Study Subjects

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We collected anthropometric data, including body weight and height, and blood pressure from subjects using standardized techniques (IRB approved). Heparinized blood was collected to measure levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine (Cre) in the hospital's inspection department. The total plasma IgE level was determined using the Two-site Sandwich Immunoassay Automated Chemiluminescence System (Centaur XP Immunoassay System, Siemens Healthcare Diagnostics, Tarrytown, NY, USA). The remaining blood was separated into plasma and cells. Plasma was stored as aliquots in liquid nitrogen until analysis was performed.

Yang C.H., Tian J.J., Ko W.S., Shih C.J, & Chiou Y.L. (2018). Oligo-fucoidan improved unbalance the Th1/Th2 and Treg/Th17 ratios in asthmatic patients: An ex vivo study. Experimental and Therapeutic Medicine, 17(1), 3-10.

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Liver Enzyme Levels Measurement

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ALT, AST, ALP, and GGT levels were measured in Siemens CentaurXP Immunoassay System following the package inserts using commercial kits from sera stored at -80^οC until the time of analysis.

Hatipoglu D, & Keskin E. (2022). The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1. Heliyon, 8(7), e09890.

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Comprehensive Anthropometric and Biomarker Assessment

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We collected anthropometric data, including body weight, height, and blood pressure, from the subjects using standardized techniques (IRB approved). Heparinized blood was collected to measure alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine (Cre). Total serum IgE levels were determined using a two-site sandwich immunoassay automated chemiluminescence system (Centaur XP Immunoassay System; Siemens Healthcare Diagnostics, Tarrytown, NY, USA). The remaining blood was separated into serum and cells. Serum was stored as aliquots in liquid nitrogen until analysis.

Yeh C.W., Shih C.J., Liu T.C, & Chiou Y.L. (2022). Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma: a randomized, double-blind, placebo-controlled trial. Scientific Reports, 12, 18150.

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Comprehensive Metabolic and Hormonal Profiling

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For each patient, the following demographic data were collected: gender, age, body height and weight. After an overnight fasting, venous blood samples of every subject were obtained for further measurement at the central chemistry laboratory of the Beijing Chao-Yang Hospital, Capital Medical University. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and Lp(a) were analyzed by colorimetric enzymatic assays using a Dade Behring Dimension RXL autoanalyzer (Dade Behring Diagnostics, Marburg, Germany). Fasting blood glucose (FBG) was estimated with glucose oxidase method using Hitachi 747 and fasting insulin (FINS) was estimated by chemiluminescence immunoassay using a Centaur XP immunoassay system (Siemens Healthcare Diagnostics, Germany). Growth hormone (GH), testosterone (TES), follicle-stimulating hormone (HFSH), prolactin (PRL), luteinizing hormone (LH) and estradiol (E2) were measured with chemiluminescence immunoassay method using Access 2 immunoassay system (Beckman Coulter, Inc., Brea, CA, USA). Body mass index (BMI) was calculated using following formula: body weight (kg)/[height(m)]². Homoeostasis model assessment of insulin resistance (HOMA-IR) was used to estimate insulin resistance, which calculated using the following formula: HOMA-IR = FBG (mmol/L) × FINS (mU/L) / 22.5.

Chang X., Bian N., Ding X., Li J., An Y., Wang J., Liu J, & Wang G. (2022). Study on the relationship between hormone and Lp(a) in Chinese overweight/obese patients. BMC Endocrine Disorders, 22, 131.

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Assessing Vitamin D Status via Serum Assay

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Serum 25(OH)D concentration was detected using the vitamin D Total Assay Kit (ADVIA Centaur®, Siemens Diagnostics Inc., USA) based on chemiluminescence method (ADVIA Centaur® XP Immunoassay System). Vitamin D status (deficient or not) was classified into VDD and non‐VDD (control) based on baseline serum 25(OH)D concentration, with reference to cut‐offs commonly used in the guideline: (1) VDD was defined as 25(OH)D concentration < 20 ng/mL; (2) control was defined as 25(OH)D concentration ≥ 20 ng/mL.¹⁵

Peng D., Gao Y., Liu Z., Zheng J, & Liu Y. (2023). Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study. The Clinical Respiratory Journal, 17(10), 1067-1076.

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Biomarker Analysis Using Automated Instruments

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C-reactive protein, and albumin, were analyzed on a Siemens Dimension Vista 1500 multiparametric analyzer (Siemens Healthcare Diagnostics, Erlangen, Germany); cortisol was analyzed on a Siemens Centaur XP Immunoassay System. The Erythrocyte sendtimentation rate (ESR) was measured with an Alifax THL sedimentation analyzer (SIRE Analytical Systems, Nimis, Italy).

Sarabon N., Löfler S., Cvecka J., Hübl W, & Zampieri S. (2018). Acute effect of different concentrations of cayenne pepper cataplasm on sensory-motor functions and serum levels of inflammation-related biomarkers in healthy subjects. European Journal of Translational Myology, 28(1), 7333.

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Metabolic Markers and Insulin Resistance

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Venous blood samples were collected from participants to determine metabolic markers, including fasting blood-glucose, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), and uric acid (UA), using an automated enzymatic method (Hitachi, Japan, 7600–020 autonomic analyzer). High-pressure liquid chromatography (BIO-RAD, USA, D-10 analyzer) was used to measure the HbA1c level. Plasma insulin was evaluated by competitive radioimmunoassay (Centaur XP immunoassay system, Siemens Healthcare Diagnostics, New York, NY). The Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, calculated by the formula: fasting plasma insulin (mU/L) x fasting plasma glucose (mmol/L)/22.5 [27 (link)], was used to assess Insulin Resistance (IR).
For man, waist circumference ≥ 85cm was used to define central obesity and for women as waist circumference ≥ 80cm [28 (link)].

Zhu Y., Lin Q., Zhang Y., Deng H., Hu X., Yang X, & Yao B. (2020). Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes. PLoS ONE, 15(5), e0231308.

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