3t biograph mmr

Manufactured by Siemens

Sourced in Germany

The Siemens 3T Biograph mMR is a magnetic resonance imaging (MRI) system designed for medical research applications. It combines a 3 Tesla superconducting magnet with integrated positron emission tomography (PET) capabilities, allowing for simultaneous acquisition of MRI and PET data. The system is intended to facilitate advanced multi-modal imaging research.

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Lab products found in correlation

20 channel head neck coil, by Siemens (1 mentions) 4 channel breast coil, by Siemens (1 mentions) Somatom definition flash, by Siemens (1 mentions) Magnetom trio, by Siemens (1 mentions) Magnetom sonata, by Siemens (1 mentions) Prohance, by Bracco (1 mentions)

13 protocols using 3t biograph mmr

Structural MRI for Cognitive Impairment

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Participants underwent magnetic resonance imaging using a Siemens 3 T Biograph mMR (software V.VE11P) with a 20-channel head/neck coil. A structural T1-weighted magnetization prepared rapid gradient echo (T1-MPRAGE) protocol (TR = 1900s, TE = 2.49 ms, TI = 900 ms; Flip Angle = 9°, voxel resolution = 0.89 × 0.89 × 0.89 mm) was acquired to examine structural correlates of cognitive impairment.

Clouston S.A., Kritikos M., Huang C., Kuan P.F., Vaska P., Pellecchia A.C., Santiago-Michels S., Carr M.A., Gandy S., Sano M., Bromet E.J., Lucchini R.G, & Luft B.J. (2022). Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment. Translational Psychiatry, 12, 107.

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Quantification of Cardiac Ejection Fraction and Vegetations

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Left ventricular ejection fraction was quantified from retrospectively gated short-axis cardiac cine MR images (Siemens 3T Biograph mMR). Acquisition parameters for cine short axis stacks were as follows: repetition time (TR) 56.24 ms, echo time (TE) 3.32 ms, number of averages 2, 24 or 30 slices, 25 cardiac frames, 3 mm slice thickness, no interslice gap, flip angle 12, spatial resolution 0.94x0.94 mm². Retrospective electrocardiogram (ECG) gating was used to acquire the images. Regions of interest (ROIs) were manually segmented with Osirix MD v 9.5.1 and exported using the ‘Export ROIs’ Osirix plugin. The cine acquisition contains a total of 600 or 750 images from 24 slices with 25 cardiac frames per slice. Right ventricle vegetations were quantified from an ECG triggered axial T2 weighted turbo spin echo (TSE) stack using the following acquisition parameters: TR 1125-1485 ms, TE 76 ms, number of averages 4, 11-24 slices, 3 mm slice thickness, no interslice gap, spatial resolution 0.94x0.94 mm². ROIs were manually segmented with Osirix MD v 9.5.1. ROIs were exported using the ‘Export ROIs’ Osirix plugin. Vegetations were segmented as high intensity areas within the right ventricle while excluding the catheter whenever possible.

Panizzi P., Krohn-Grimberghe M., Keliher E., Ye Y.X., Grune J., Frodermann V., Sun Y., Muse C.G., Bushey K., Iwamoto Y., van Leent M.M., Meerwaldt A., Toner Y.C., Munitz J., Maier A., Soultanidis G., Calcagno C., Pérez-Medina C., Carlucci G., Riddell K.P., Barney S., Horne G., Anderson B., Maddur-Appajaiah A., Verhamme I.M., Bock P.E., Wojtkiewicz G.R., Courties G., Swirski F.K., Church W.R., Walz P.H., Tillson D.M., Mulder W.J, & Nahrendorf M. (2020). Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis. Science translational medicine, 12(568), eaay2104.

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Breast MRI Protocol for Diagnosis

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MR examinations were performed on a 3T Biograph mMR (Siemens Healthcare, Erlangen, Germany) with a dedicated 4-channel breast coil. The imaging protocols included a Turbo inversion recovery magnitude (TIRM) sequence (TR = 4200 ms, TE = 60 ms, TI = 230 ms, FOV = 380 × 380 mm², resolution = 1.48 × 1.48 mm², and slice thickness = 4 mm); 6 gradient echo volumetric interpolated breath-hold examination (VIBE) sequences at variable flip angle (FA) for T1 mapping (TR = 5.3 ms, TE = 1.9 ms, FAs = [2°, 5°, 8°, 12°, 15°, 20°], FOV = 356 × 379 mm², resolution = 1.98 × 1.98 mm², and slice thickness = 3.6 mm); a dynamic scan with 60 consecutive phases with a VIBE sequence (TR = 5.3 ms, TE = 1.9 ms, FA = 20°, FOV = 356 × 379 mm², resolution = 1.98 × 1.98 mm², slice thickness = 3.6 mm, and temporal resolution = 9 s/phase); and a delayed 3D postcontrast fat-suppressed T1-weighted gradient echo sequences (TR = 8.4 ms, TE = 2.5 ms, FOV = 370 × 370 mm², resolution = 0.82 × 0.82 mm², and slice thickness = 0.89 mm). Intravenous contrast injection started at the end of the first phase of dynamic scan at a dose of 0.1 mmol/kg of body weight and at the highest rate compatible with patient's age and compliance (up to 5 mL/s)

Monti S., Aiello M., Incoronato M., Grimaldi A.M., Moscarino M., Mirabelli P., Ferbo U., Cavaliere C, & Salvatore M. (2018). DCE-MRI Pharmacokinetic-Based Phenotyping of Invasive Ductal Carcinoma: A Radiomic Study for Prediction of Histological Outcomes. Contrast Media & Molecular Imaging, 2018, 5076269.

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High-Resolution 3D Structural Brain Imaging

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For each monkey, a three-dimensional structural T1-weighted magnetization-prepared rapid gradient-echo (MEMPRAGE) magnetic resonance (MR) image was acquired using a 3T Biograph mMR (Siemens Medical Systems) for anatomical reference. Acquisition parameters were as follows: repetition time = 2530 ms; echo time = 1.69 ms; inversion time = 1100 ms; flip angle = 7; voxel size = 1 × 1 × 1 mm³; matrix size = 256 × 256 × 176; number of averages = 4.

Zhou Y.P., Normandin M.D., Belov V., Macdonald-Soccorso M.T., Moon S.H., Sun Y., Fakhri G.E., Guehl N.J, & Brugarolas P. (2023). Evaluation of trans- and cis-4-[18F]fluorogabapentin for brain PET imaging. bioRxiv.

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PET/MR Phantom Measurements and Clinical Evaluation

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In this work, we investigated the proposed algorithm performing phantom measurements and evaluating clinical patient data. All PET data were acquired with an integrated clinical PET/MR device (3T Biograph mMR, Siemens Healthineers, Erlangen, Germany) [47 (link)]. CT-based attenuation maps of the phantoms and the hardware components were obtained with a clinical spiral CT device (SOMATOM Definition Flash, Siemens Healthineers, Forchheim, Germany)

Heußer T., Rank C.M., Berker Y., Freitag M.T, & Kachelrieß M. (2017). MLAA-based attenuation correction of flexible hardware components in hybrid PET/MR imaging. EJNMMI Physics, 4, 12.

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MRI Dataset Comparison for Dementia Research

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For evaluation, we used T1‐weighted (T1w) MRI from two publicly available datasets: OASIS‐3 (LaMontagne et al., 2018) and SIMON (Duchesne et al., 2019), yielding a total of 2,736 images. OASIS‐3 contains cross‐sectional and longitudinal samples from cognitively normal adults, as well as participants at various stages of dementia, as assessed by the Clinical Dementia Rating (CDR) (Morris, 1991). Data from SIMON stem from a single healthy male volunteer known as “the traveling human phantom,” providing repeated measures from different sites over a time span of 16 years. Demographic information is listed in Table 1. The images from OASIS‐3 were all acquired on three different models of Siemens scanners (1.5 T MAGNETOM Sonata, and 3T Biograph mMR and MAGNETOM Trio), whereas SIMON contains data from various models of Siemens, Philips, and GE. No data from the OASIS‐3 or SIMON datasets were used to train the brain anatomy segmentation model described above.

Rebsamen M., Rummel C., Reyes M., Wiest R, & McKinley R. (2020). Direct cortical thickness estimation using deep learning‐based anatomy segmentation and cortex parcellation. Human Brain Mapping, 41(17), 4804-4814.

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Structural Brain Imaging in Monkeys

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For each monkey, a 3-dimensional structural T1-weighted magnetization-prepared rapid gradient-echo (MEMPRAGE) was acquired using a 3T Biograph mMR (Siemens Medical Systems) for anatomical reference. Acquisitions parameters were as follows: repetition time =2,530 ms; echo time =1.69 ms; inversion time =1100 ms; flip angle = 7; voxel size = 1x1x1 mm³ and matrix size = 256 x 256 x 176, number of averages= 4.

Guehl N.J., Neelamegam R., Zhou Y.P., Moon S.H., Dhaynaut M., Fakhri G.E., Normandin M.D, & Brugarolas P. (2021). Radiochemical synthesis and evaluation in nonhuman primates of 3-[11C]methoxy-4-aminopyridine: a novel PET tracer for Imaging Potassium Channels in the CNS. ACS chemical neuroscience, 12(4), 756-765.

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Multiparametric MRI Protocol for Oncology

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mpMRI examinations were performed on a 3T Biograph mMR (Siemens Healthcare, Erlangen, Germany) with a body surface coil. The imaging protocols included a T2W (Repetition Time [TR] = 4010 ms, Echo Time [TE] = 112 ms, in plane field of view [FOV] = 200 × 200 mm², number of slices = 26, resolution = 0.6 × 0.6 mm2, slice thickness = 3 mm), DWI (TR = 7000 ms, TE = 86 ms, in plane FOV = 260 × 220 mm², number of slices = 26, resolution = 2 × 2 mm², slice thickness = 3 mm, b values = 0, 250, 500 (4 averages), 1000, 1500 (6 averages), 2000, 2500 (8 averages) s/mm²), 6 gradient echo Volumetric Interpolated Breath-hold Examination (VIBE) sequences at variable flip angles (FAs) for T1 mapping (TR = 5.58 ms, TE = 1.83 ms, FAs = (2°, 5°, 8°, 12°, 15°, 20°), in plane FOV = 243 × 260 × 80 mm³, slice gap 20%, resolution = 1.4 ×1.4 × 3.0 mm³), and a dynamic scan with 60 consecutives phases with a VIBE sequence (TR = 5.58 ms, TE = 1.83 ms, FA = 20°, FOV = 243 × 260 × 80 mm³, resolution = 1.4 × 1.4 × 3.0 mm³, temporal resolution = 9 s/phase). Intravenous contrast injections started at the end of the first phase of dynamic scan at a dose of 0.1 mmol/kg of body weight and at the highest rate compatible with the patient’s age and compliance (up to 5 mL/s)

Monti S., Brancato V., Di Costanzo G., Basso L., Puglia M., Ragozzino A., Salvatore M, & Cavaliere C. (2020). Multiparametric MRI for Prostate Cancer Detection: New Insights into the Combined Use of a Radiomic Approach with Advanced Acquisition Protocol. Cancers, 12(2), 390.

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3T MRI Structural Imaging Protocol

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Before PET studies the animal was scanned on a 3T Biograph mMR (Siemens Medical Systems) to acquire MRI for anatomical reference. Data was acquired using a 3D structural T1-weighted multi-echo magnetization-prepared rapid gradient-echo (MEMPRAGE) sequence with repetition time (TR) = 2,530 ms, echo time (TE) = 5.82 ms, inversion time (TI) = 1,100 ms; flip angle = 7°, voxel size = 0.7×0.7×0.7 mm³, matrix size = 256×256×160, and number of averages = 1.

Yuan G., Guehl N.J., Zheng B., Qu X., Moon S.H., Dhaynaut M., Shoup T.M., Afshar S., Kang H.J., Zhang Z., Fakhri G.E., Normandin M.D, & Brownell A.L. (2021). Synthesis and characterization of [18F]JNJ-46356479 as the first 18F-labeled PET imaging ligand for metabotropic glutamate receptor 2. Molecular imaging and biology, 23(4), 527-536.

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Multiparametric MRI Breast Imaging Protocol

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MRI examinations of the DS

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were performed using a 3 T Biograph mMR (Siemens Healthcare, Erlangen, Germany) with a dedicated breast surface coil. T2 Turbo spin-echo (TSE T2) sequence was acquired on an axial plane before contrast-agent injection, and DWI with b values of 50, 500, and 800 s/mm

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was acquired on the axial plane with their corresponding ADC maps. DCE-MRI studies were obtained with intravenous administration of paramagnetic contrast agent (Prohance, Bracco Imaging, Italy) 0.3 mmol/kg, a flow rate of 3.5 mL/s, injected after six pre-contrast transaxial T1 Vibe with flip angles of 2

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, and 20°, followed by a T1 Vibe axial dynamic (TR/TE = 5.47/1.75) with 60 measurements over a 10 min period and a temporal resolution of 9.6 s. Subtracted DCE images (SUB) were obtained automatically by subtracting pre-contrast images from the post-contrast (PC) images. Finally, an axial high-resolution T1 Vibe with fat suppression (HR Vibe T1-w fat sat) was acquired. Technical details of MRI sequences are shown in Table 1.

Brancato V., Brancati N., Esposito G., La Rosa M., Cavaliere C., Allarà C., Romeo V., De Pietro G., Salvatore M., Aiello M, & Sangiovanni M. (2023). A Two-Step Feature Selection Radiomic Approach to Predict Molecular Outcomes in Breast Cancer. Sensors (Basel, Switzerland), 23(3), 1552.

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