Antibodies against caspase-8 (SAB5701263), caspase-3 (SAB5700914), caspase-9 (SAB5700785), cyclin-D1 (SAB140551), cyclin-E2 (SAB4503557), phospho-Akt (05-1003), Akt (SAB4500797), phospho-P70S6K (SAB4301562), P70S6K (SAB2500736), phospho-4E-BP1 (SAB4301339), 4E-BP1 (SAB4500736), phospho-S6RP (SAB5700395), S6RP (SAB4300484), LC3-II (L8918), LC3-I (L8918), and GAPDH (G9545) were purchased from Sigma-Aldrich, USA. PI3K/mTOR inhibitors LY294002 (S1105), rapamycin (S1039), NVP-BEZ235 (S1009), and autophagy inhibitors 3-Methyladenine (3-MA, S2767) and Chloroquine Phosphate (CQ, S4157) were purchased from Selleck, USA.
Nvp bez235 s1009
Manufactured by Selleck Chemicals
Sourced in United States, China
NVP-BEZ235 (S1009) is a dual PI3K/mTOR inhibitor. It functions by inhibiting the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathways.
Automatically generated - may contain errors
Lab products found in correlation
Gapdh, by Merck Group (1 mentions)
Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions)
Phospho akt, by Cell Signaling Technology (1 mentions)
Bcl2 associated x (bax), by Cell Signaling Technology (1 mentions)
Phospho p70 s6 kinase, by Cell Signaling Technology (1 mentions)
Ab109012, by Abcam (1 mentions)
P70 s6 kinase, by Cell Signaling Technology (1 mentions)
Caspase 3, by Cell Signaling Technology (1 mentions)
Gapdh, by Cell Signaling Technology (1 mentions)
Bcl 2, by Cell Signaling Technology (1 mentions)
Anti lc3b, by Cell Signaling Technology (1 mentions)
2 protocols using nvp bez235 s1009
1
Investigating PI3K/mTOR and Autophagy Pathways
2
Regulation of Autophagy-Apoptosis Crosstalk
Check if the same lab product or an alternative is used in the 5 most similar protocols
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DMEM, foetal bovine serum (FBS) and penicillin/streptomycin (pen/strep, 10,000 U/ml each) were purchased from the GIBCO Company (Life Technologies, Shanghai, China). NVP‐BEZ235 (S1009) was obtained from Selleck (Shanghai, China). The precursor of miR‐21 (cat no. BP0000850), the negative control miRNA (cat no. BP0000038) and the transfection kit (C10511‐1) were purchased from RiboBio (Guangzhou, China). The rabbit monoclonal antibody to p62 (ab109012) was obtained from Abcam (Cambridge, UK). The anti‐LC3B (cat no. 2775), Caspase‐3 (cat no. 9662), Bcl‐2 (cat no. 2870), Bax (cat no. 5023), PTEN (cat no. 9188), Akt (cat no. 9272), Phospho‐Akt (cat no. 4060), p70S6 Kinase (cat no. 2078), Phospho‐p70S6 Kinase (cat no. 9205) and GAPDH (cat no. 5174) antibodies were purchased from Cell Signaling Technology (Danvers, MA, USA). The goat anti‐rabbit secondary antibodies (cat no. 21109) used for the Western blots were obtained from Invitrogen (Carlsbad, CA, USA).
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