Unless contraindicated, children underwent magnetic resonance imaging (MRI) using a Siemens Prisma® (Siemens Medical Solutions, Malvern, PA), General Electric Discovery™ MR750 (GE Healthcare, Chicago, IL), or Philips Achieva (Koninklijke Philips, Amsterdam, Netherlands) scanner. Standard adult coils provided high resolution images harmonized using the following settings: T1-weighted: MP-RAGE with 256×256 matrix size, 176 slices, 1 mm resolution in all axes, TR=6.31 ms, TE=2500 ms and TI=1060 ms; flip angle=8 deg; 2-fold parallel imaging; multiband off.12 (link) Cortical thickness, area, and volume were calculated using a Freesurfer-based pipeline13 (link) using the Destrieux atlas,14 (link) which parcellated 74 cortical and subcortical brain regions/hemisphere. Cortical effect size maps were generated using Nilearn.15 (link)
General electric discovery mr750
Manufactured by GE Healthcare
The General Electric Discovery MR750 is a magnetic resonance imaging (MRI) system designed for diagnostic imaging. It provides high-quality images to support clinical decision-making. The system utilizes advanced MRI technology to capture detailed anatomical information.
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5 protocols using general electric discovery mr750
1
MRI-Based Brain Structural Analysis Pipeline
2
MRI-Based Brain Structural Analysis Pipeline
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Unless contraindicated, children underwent magnetic resonance imaging (MRI) using a Siemens Prisma® (Siemens Medical Solutions, Malvern, PA), General Electric Discovery™ MR750 (GE Healthcare, Chicago, IL), or Philips Achieva (Koninklijke Philips, Amsterdam, Netherlands) scanner. Standard adult coils provided high resolution images harmonized using the following settings: T1-weighted: MP-RAGE with 256×256 matrix size, 176 slices, 1 mm resolution in all axes, TR=6.31 ms, TE=2500 ms and TI=1060 ms; flip angle=8 deg; 2-fold parallel imaging; multiband off.12 (link) Cortical thickness, area, and volume were calculated using a Freesurfer-based pipeline13 (link) using the Destrieux atlas,14 (link) which parcellated 74 cortical and subcortical brain regions/hemisphere. Cortical effect size maps were generated using Nilearn.15 (link)
3
Contrast-enhanced Brain MRI Imaging Protocol
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All brain MRI scans were performed without and with intravenous administration of a gadolinium-based contrast agent, Gadobutrol (Gadavist). Imaging was obtained on the following three Tesla scanners using a 32-channel head coil: Siemens Magnetom Skyra and Siemens PRISMA (Siemens Healthcare), and General Electric Discovery MR750 (General Electric Healthcare). The following 1.5-Tesla scanners were used as well, using a 12-channel head coil: General Electric Signa Explorer and General Electric Signa HDxt (General Electric Healthcare). Images were interpreted by a board-certified pediatric neuroradiologist (D.P.R.). MRI factors were incorporated as factors for assessing the patient's response to treatment in accordance with the Response Assessment in Neuro-Oncology (RANO) criteria (Wen et al. 2017 (link)).
4
3T MRI Structural and Functional Imaging
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MRI images were acquired on two identical General Electric Discovery MR750 (GE Healthcare, Milwaukee, WI) whole-body 3-Tesla MRI scanners. The structural scan was acquired using a T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) sequence. Anatomical imaging parameters were repetition time (TR)/echo time (TE) = 5/2.012 ms, field of view (FOV) = 240, 186 axial slices, 0.9 mm slice thickness, 256 ×256 matrix, voxel volume = 0.938 × 0.938 × 0.9 mm3, flip angle = 8°, acceleration factor R = 2, inversion time = 725 ms. A single-shot gradient-recalled echo-planar imaging (EPI) sequence with Sensitivity Encoding (SENSE) depicting BOLD contrast was used for functional scans. Functional imaging parameters were TR/TE = 2000/27 ms, FOV/slice = 240/2.9 mm, 128 × 128 acquisition matrix, 39 axial slices, 180 TRs, flip angle = 78°, SENSE acceleration factor R = 2 in anterior-posterior direction, and voxel volume = 1.875 × 1.875 × 2.9 mm3.
5
Structural and Functional 3T MRI Acquisition
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MRI images were acquired on two identical General Electric Discovery MR750 (GE Healthcare, Milwaukee, WI) whole-body 3-Tesla MRI scanners. The structural scan was acquired using a T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) sequence. Anatomical imaging parameters were repetition time (TR)/echo time (TE) = 5/2.012 ms, field of view (FOV) = 240, 186 axial slices, 0.9 mm slice thickness, 256 × 256 matrix, voxel volume = 0.938 × 0.938 × 0.9 mm3, flip angle = 8°, acceleration factor R = 2, inversion time = 725 ms. A single-shot gradient-recalled echo-planar imaging (EPI) sequence with Sensitivity Encoding (SENSE) depicting BOLD contrast was used for functional scans. Functional imaging parameters were TR/TE = 2000/27 ms, FOV/slice = 240/2.9 mm, 128 × 128 acquisition matrix, 39 axial slices, 180 TRs, flip angle = 78°, SENSE acceleration factor R = 2 in anterior-posterior direction, and voxel volume = 1.875 × 1.875 × 2.9 mm3.
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