Continuous variables are presented as means ± SD or as medians and interquartile ranges and compared using Student’s
t test or Wilcoxon rank-sum test (Mann-Whitney) as appropriate. Categorical variables are presented as absolute values (percentage) and compared using χ
2 statistics. Multivariable linear regression analyses were used to assess the relationship between cBMI with 3D echocardiography LA structure/function parameters, assessed by two analytic models: model 1 was adjusted for demographics at year 30 examination (age and race); model 2 included model 1 with adjustment for traditional CV risk factors at year 30 examination (heart rate, education level, physical activity, systolic blood pressure, smoking status, diabetes, alcohol intake, LDL cholesterol, and HDL cholesterol). Effect modification by sex on the association of cBMI with several LA parameters was observed; therefore, all assessments were stratified by sex. All analyses were conducted using
STATA 14.2 version for Windows (StataCorp LP, College Station, TX). A two-tail
P value < .05 was considered statistically significant.
de Vasconcellos H.D., Betoko A., Ciuffo L.A., Moreira H.T., Nwabuo C.C., Ambale-Venkatesh B., Reis J.P., Allen N., Lloyd-Jones D.M., Colangelo L.A., Schreiner P.J., Lewis C.E., Shikany J.M., Sidney S., Cox C., Gidding S.S, & Lima J.A. (2020). Sex Differences in the Association of Cumulative Body Mass Index from Early Adulthood to Middle Age and Left Atrial Remodeling Evaluated by Three-Dimensional Echocardiography: The Coronary Artery Risk Development in Young Adults Study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 33(7), 878-887.e3.