Augmentin

For the entire duration of the post-operative period, all patients were prescribed:-

1 g of Amoxicillin 875 mg + Clavulanic acid 125 mg (Augmentin, Glaxo Smith Kline, Brentford, UK) twice a day for a period of five days after the procedure;

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0.20% chlorhexidine mouthwash (Corsodyl, GlaxoSmithKline, Rixensart, Belgium) rinse two times a day for around one minute for the next 15 days;

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Soft diet for the two months after the surgical;

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The light smokers were remembered to limit and possibly to refrain from smoking.

Eligible patients were assigned into two groups by a computer generated random table with blocks based on gender. Sealed envelopes which were opened in the outpatient clinic without blinding were used for allocation concealment. The LAcR group received levofloxacin, 500 mg (Cravit, Daiichi-Sankyo, Japan) b.i.d., amoxicillin/clavulanate, 875 mg/125 mg (Augmentin, GlaxoSmithKline, UK) b.i.d., and rabeprazole, 20 mg (Pariet, Eisai, Japan) b.i.d., for 7 days. The standard triple therapy group served as the control group and was treated with clarithyromicin, 500 mg (Klaricid, Abbott, USA) b.i.d., amoxicillin, 1000 mg (Amoxicillin capsule 250 mg, Yung-Shin, Taiwan) b.i.d., and rabeprazole, 20 mg b.i.d. (CAR), for seven days.

Hairy roots were generated via infection of Agrobacterium tumefaciens R-1000
strain. This strain carries a hairy-root-inducing Ri plasmid, pRiA4b, instead of Ti
plasmids^{26 (link),27 (link))}. For this experiment, two-month-old LUC
plants grown in plant culture vessels were infected by pricking using a syringe needle
containing Agrobacterium cells. The prick occurred on the stem 2−3 cm above
the root, and hairy roots usually formed two weeks after infection. Next, normal roots were
removed by cutting the stems of LUC plants just below the site of hairy root formation. The
resulting LUC plants with hairy roots (called “hr-LUC plants”) were transferred to a
Murashige-Skoog solid medium containing 750 mg/L Augmentin (GlaxoSmithKline, Brentford, UK)
then grown in plant culture vessels. After 3 weeks, aseptically grown WT scions were grafted
onto hr-LUC rootstocks (Fig. 4).
Similarly, LUC plants grown in plant culture vessels were used for grafting onto WT plants. The
numbers of the WT/hr-LUC and WT/LUC transgrafted plants were 5 and 13, respectively. The leaves
of two WT/hr-LUC plants were harvested at 3 WAG. The other three WT/hr-LUC plants were
transferred on soil on the same day, then subsequently cultured for another three weeks. We
obtained leaf and stem samples on 4, 6, and 8 WAG, and subjected these samples to measurements
of LUC activity.

Collected data over 20 years included animal signalment, clinical signs, neurologic and radiographic results, initiated treatment, and outcome. At admission, animals were placed under general anesthesia or sedation to obtain lateral and ventrodorsal radiographs of the pelvis. Treatment procedures were decided based on radiographic findings and fracture location. The animals were classified into two groups after analyzing the records. Group 1 (8 animals) included animals with acetabular involvement that underwent conservative treatment with femoral head-and-neck excision. Group 2 (34 animals) included animals without acetabular involvement that underwent conservative treatment only. Experienced academic surgeons performed the surgery.
Post-operative pain management included the intravenous injection of buprenorphine and a prescription for an oral nonsteroidal anti-inflammatory drugs (NSAIDs) medication (meloxicam, Metacam^®; Boehringer Ingelheim, Germany) for 5 days. Post-operative treatment comprised antibiotic therapy (amoxicillin/clavulanate, Augmentin^®; GlaxoSmithKline, UK) in Group 1, whereas Group 2 animals received an NSAID (meloxicam, Metacam^®; Boehringer Ingelheim, Ingelheim am Rhein, Germany) at a dose of 0.1-0.2 mg/kg orally for 15 days and a paraffin laxative to produce soft stools.

GVHD was induced as described previously (Ilan et al., 2007 (link)) with 750 rad of total-body irradiation. This dose has been shown to be nonlethal in C57BL/6 as well as in BALB/c mice. Where indicated, mice were treated with 0.2 mg/g body weight per day with the broad-spectrum antibiotic Augmentin (GlaxoSmithKline) (25 μl of 80 mg/ml per os every 12 hours) for the course of the experiment.
For the transfer experiment, (C57BL/6 × BALB/c) F₁ were transplanted with splenocytes from Ncr1^+/+ and Ncr1^gfp/gfp mice, respectively, as described above. On day 9 posttransplantation, blood was collected and 100 μl from each group was injected i.v. into nonirradiated Ncr1^+/+ and Ncr1^gfp/gfp mice, respectively.

Antibiotic prophylaxis of amoxicillin + clavulanic acid 2 g/day for six days (Augmentin, GlaxoSmithKline plc., Brentford, UK), starting with 2 g 1 h before surgery or clindamycin 600 mg/day for six days (Dalacin, Pfizer Inc., New York, NY, USA) in penicillin-allergic patients was prescribed to reduce the possibility of infections. Anti-inflammatory therapy with NSAIDs was also recommended: ketoprofen lysine 80 mg/day for three days (OKI, Dompè, Shanghai, China), starting with 80 mg 1 h before surgery. Local anesthesia of lidocaine + adrenalin 1:50,000 (Ecocain, Molteni Dental Srl, Milan, Italy) was administered at the site of intervention and articaine + adrenalin 1: 100,000 (Citocartin, Molteni Dental Srl, Milan, Italy) at other sites.

All patients were prescribed amoxicillin (Augmentin, GlaxoSmithKline, London, UK) 1 g twice daily for seven days. After surgery, analgesia was achieved with 200 mg of ketoprofen (Ibifen, Aprilia, Latina, Italy) for a maximum of three times days according to the needs of individual patients. Each patient was instructed to rinse with 0.12% chlorhexidine digluconate (Corsodyl, GlaxoSmithKline Consumer Healthcare S.p.A., Baranzate, Milan, Italy) three times daily for two weeks, to follow a soft diet for one week, and to gently clean with a soft toothbrush while avoiding flossing in the surgical area for the first month post-operatively.