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Ifenprodil tartrate salt

Manufactured by Merck Group
Sourced in United States, Germany

Ifenprodil tartrate salt is a chemical compound used in scientific research and laboratory settings. It is a salt form of the active pharmaceutical ingredient ifenprodil. The compound is typically used as a research tool to study various biological and pharmacological processes.

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3 protocols using ifenprodil tartrate salt

1

Optimizing Neurochemical Assay Conditions

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DMEM was obtained from the Hyclone (Logan, UT, USA). Collagenase II was purchased from Gibco BRL (Grand Island, New York, USA). Bovine serum albumin (BSA), Gelatin, and glutamic acid were purchased from Amresco (Solon, OH, USA). Polyvinylidene fluoride (PVDF) were obtained from Prospec (ProSpec, Ness-Ziona, Israel). NMDAR2b was purchased from Chemicon (Temecula, CA, USA). Memantine hydrochloride and ifenprodil tartrate salt were purchased from Sigma-Aldrich (St. Louis, Missouri, USA). Other chemicals were of the highest purity available.
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2

GluN2B Antagonist Modulates Extinction Memory

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Ifenprodil tartrate salt (Sigma Aldrich), a noncompetitive, selective antagonist for GluN2B containing NMDA receptors, was dissolved in distilled water for systemic administration. To determine the influence of GluN2B receptor blockade on VNS modulation of consolidation of extinction, immediately after extinction training or extended extinction, rats were injected with 5 mg/kg of ifenprodil or vehicle (i.p.) and returned to their cages. On day 5 rats were subjected to a CFRT drug-free.
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3

Ifenprodil disrupts spatial learning

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The GluN2B-antagonist Ifenprodil (Gallagher et al., 1996 (link); Williams, 2001 (link)) was applied as Ifenprodil (+)-tartrate salt (Sigma, Taufkirchen, Germany) and was dissolved in distilled water and applied at a dose of 10 mg/kg, i.p., in 10 ml/kg. An equivalent dose is known to disrupt spatial learning (Ma et al., 2011 (link)).
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