The APIs fenofibrate (FFB), ibuprofen (IBU), indomethacin (IND) and felodipine (FEL) with purity >98% were purchased from TCI (Tokyo, Japan). Cinnarizine (CIN), griseofulvin (GRI), glibenclamide (GLI) were purchased from Alfa Aesar (Karlsruhe, Germany) possessing a purity >97%. Tricaprylin (TG808080) and carbitol were purchased from Sigma Aldrich (Steinheim, Germany) with purity >99%. The glycerides are abbreviated in this work according to [22 (link)] (e.g. tricaprylin: TG808080, monolaurin: MG80: The first two letters define the type of component (TG = triglyceride, DG = diglyceride and MG = monoglyceride. The capital numbers give the number of carbon atoms in each carbon chain and the subscript denotes the number of unsaturated bonds in each carbon chain.
Caprylic acid (MC80) was obtained from Merck (Darmstadt, Germany) with purity 99%. Capryol 90™ (Capryol 90) was provided by Gattefosse (Saint-Priest Cedex, France). Kolliphor® TPGS (TPGS1000) was provided by BASF (Ludwigshafen, Germany). The surfactants Capryol 90 and TPGS1000 were taken from the same batches as in a recent work [17 (link)]. Water was purified by Milli-Q from Merck Millipore (Darmstadt, Germany). Acetonitrile used for the mobile phase in the HPLC was of analytical grade with minimal purity of 99.9% from VWR Chemicals (Darmstadt, Germany). Phosphoric acid was purchased from Sigma Aldrich with purity >99.9%.
Caprylic acid (MC80) was obtained from Merck (Darmstadt, Germany) with purity 99%. Capryol 90™ (Capryol 90) was provided by Gattefosse (Saint-Priest Cedex, France). Kolliphor® TPGS (TPGS1000) was provided by BASF (Ludwigshafen, Germany). The surfactants Capryol 90 and TPGS1000 were taken from the same batches as in a recent work [17 (link)]. Water was purified by Milli-Q from Merck Millipore (Darmstadt, Germany). Acetonitrile used for the mobile phase in the HPLC was of analytical grade with minimal purity of 99.9% from VWR Chemicals (Darmstadt, Germany). Phosphoric acid was purchased from Sigma Aldrich with purity >99.9%.