Flutamide flu

Manufactured by Merck Group

Sourced in United States

Flutamide is a non-steroidal anti-androgen medication developed by Schering-Plough, now owned by Merck. It functions as an antagonist of the androgen receptor, blocking the effects of androgens such as testosterone and dihydrotestosterone. Flutamide is primarily used in the treatment of prostate cancer.

Automatically generated - may contain errors

Lab products found in correlation

Sesame oil, by Merck Group (1 mentions) 17β estradiol e2, by Merck Group (1 mentions) Streptomycin, by Thermo Fisher Scientific (1 mentions) Penicillin, by Thermo Fisher Scientific (1 mentions) Epidermal growth factor (egf), by Merck Group (1 mentions) Fetal calf serum (fcs), by Merck Group (1 mentions) Hygromycin b, by Thermo Fisher Scientific (1 mentions) Sodium bicarbonate, by Dutscher (1 mentions) Ici 182 780 ici, by Bio-Techne (1 mentions) 17α ethynylestradiol ee2, by Merck Group (1 mentions)

Spelling variants of this product

Flutamide (73 citations)

3 protocols using flutamide flu

Testosterone Modulation in Orchiectomized Rats

Check if the same lab product or an alternative is used in the 5 most similar protocols

Two to three months old male rats underwent bilateral ORX or sham operation under anesthesia with sodium pentobarbital (40 mg/kg; Koch-Light. Lab. Ltd., Colnbrook, Bucks, England). After 1-week recovery, the rats were divided into three and/or five groups: 1. sham-operated (Sham) rats were subcutaneously injected with sesame oil (Sigma-Aldrich, St Louis, MO, USA) as a control; 2. ORX rats were subcutaneously injected with sesame oil; 3. ORX rats were treated with testosterone propionate (TP, 2 mg/kg; Fluka, Buchs, Switzerland) (ORX + TP) via subcutaneous injection; 4. ORX rats were subcutaneously injected with TP combined with flutamide (Flu, 6 mg/kg; Sigma-Aldrich, St Louis, MO, USA) (ORX + TP + Flu); 5. ORX rats were subcutaneously injected with Flu (ORX + Flu) once daily for 7 days.

Lin P.H., Jian C.Y., Chou J.C., Chen C.W., Chen C.C., Soong C., Hu S., Lieu F.K., Wang P.S, & Wang S.W. (2016). Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats. Scientific Reports, 6, 32085.

+ Open protocol

+ Expand

Flutamide Effects on Pig Ovaries

Check if the same lab product or an alternative is used in the 5 most similar protocols

The experiment was conducted in accordance with the national guidelines and approved by the Local Ethics Committee at the Jagiellonian University in Krakow, Poland (approval number 150/2013, 187/2014 and 188/2014). Surgical procedures were performed by a veterinarian. In the present study, six pig neonates (Large White × Polish Landrace) from different litters were randomly allocated into two groups. Animals of the first group (n = 3) were injected s.c. daily with flutamide (FLU; Sigma-Aldrich, St. Louis, MO, USA) between postnatal days 1 and 10. Flutamide was suspended in corn oil and administered at a dose of 50 mg/kg body weight. This dose was chosen on the basis of our previous experiments [13 (link), 14 (link)] as well as literature review [20 (link), 21 (link)] to effectively antagonize androgen action without exerting any toxic effects in the pigs. Animals in the second group (n = 3) served as controls (CTR) and were given a vehicle only (corn oil). On the day after the last injection (postnatal day 11), both ovaries from the two groups were excised and one gonad was snap frozen in liquid nitrogen for RNA isolation, while the contralateral gonad was fixed in Bouin’s solution. All piglets were housed with theirs mothers and siblings during the entire experiment.

Knapczyk-Stwora K., Nynca A., Ciereszko R.E., Paukszto L., Jastrzebski J.P., Czaja E., Witek P., Koziorowski M, & Slomczynska M. (2019). Flutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries. Journal of Animal Science and Biotechnology, 10, 35.

+ Open protocol

+ Expand

Endocrine Disruptors Exposure Evaluation

Check if the same lab product or an alternative is used in the 5 most similar protocols

2,2-Bis(4-hydroxyphenyl)propane (BPA, CAS # 80-05-7), 4,4′-sulfonyldiphenol (BPS, CAS # 80-09-1), bis(4-hydroxyphenyl)methane (BPF, CAS # 620-92-8), 17β-estradiol (E2, CAS #r 50-28-2), 17α-ethynylestradiol (EE2, CAS # 57-63-6) were purchased from Sigma-Aldrich (Quentin Fallavier, France). Leibovitz 15 culture medium (L15), 4-(2hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), F-12 nutrient mixture (Ham's F12) powder, Dulbecco's Modified Eagle Medium High Glucose (DMEM HG) powder, G418, hygromycin B, penicillin and streptomycin were purchased from Fischer Scientific (Illkirch, France). Fetal calf serum (FCS) and epidermal growth factor (EGF) were purchased from Sigma-Aldrich (Quentin Fallavier, France) and sodium bicarbonate and insulin from Dominique Dutscher (Brumath, France). ICI 182-780 (ICI) was purchased from Tocris (Bristol, UK) and flutamide (FLU) was obtained from Sigma-Aldrich (Quentin Fallavier, France).

Le Fol V., Aït-Aïssa S., Sonavane M., Porcher J.M., Balaguer P., Cravedi J.P., Zalko D, & Brion F. (2017). In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays. Ecotoxicology and environmental safety, 142.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!