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Nitropen

Manufactured by Nippon Kayaku
Sourced in Japan

Nitropen is a laboratory equipment designed for the analysis and measurement of nitrogen content in various samples. It utilizes a combustion-based technique to determine the total nitrogen present in the tested material.

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2 protocols using nitropen

1

Optimized Coronary CTA Protocol

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A 320-row CT was used to perform coronary CT angiography (Aquilion ONE Genesis Edition; Canon Medical Systems Corporation). Oral β-blocker (metoprolol, 20 or 40 mg) was used 1 h before the exam to achieve the target heart rate of 65 beats per minute. A maximum dose of 12.5 mg of landiolol (Corebeta; Ono Parmaceutical) was given intravenously if the heart rate was > 65 bpm at the CT room [18 ]. All patients received 0.6 mg of sublingual nitroglycerin (Nitropen; Nippon Kayaku) before imaging. Patients received 18.0 mg iodine/kg/s of iomeprol (Iomeron 350; Eisai) for 12 s, followed by a 30 ml saline flush. Images were reconstructed with slice thickness and increment of 0.50 mm and 0.25 mm, respectively, using a convolution kernel of FC04 with iterative reconstruction (AIDR 3D [adaptive iterative dose reduction using a three-dimensional processing algorithm]; Canon Medical Systems Corporation). Images were transferred to a workstation for postprocessing (Synapse Vincent, version 6.0; Fujifilm Medical).
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2

Calcification Impact on Coronary Imaging

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During the period from November 2015 to March 2018, a total of 1797 CCTA were performed. From this cohort, we selected 123 consecutive cases with severe calcification that could not be evaluated in at least one segment and who had undergone invasive coronary angiography (ICA). Among them, 9 cases with poor image quality due to motion artifacts and poor contrast, 5 cases without raw CT data, 1 case for which ICA results could not be confirmed, and 9 cases in which unevaluable segments were placed in the peripheral branch were excluded. Based on the above results, 99 cases were evaluated.
This study was approved by the ethics committee of our institution (H17-0092), and written informed consent was waived due to the retrospective nature of the study. All patients received 0.6 mg sublingual nitroglycerine (Nitropen; Nippon Kayaku, Tokyo, Japan). Patients with a heart rate of ≥ 60 bpm were given 20–40 mg of metoprolol (Lopressor®; Tanabe Seiyaku, Osaka, Japan) orally at 1 h before scanning. If the heart rate remained at ≥ 60 bpm before scanning, 0.125 mg/kg of landiolol (Corebeta®; Ono Pharmaceutical, Osaka, Japan) was administered intravenously.
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