Milli q water ddh2o

All reagents were of HPLC grade. Milli-Q water (ddH₂O; Millipore) was prepared in-house. Conductive indium tin oxide (ITO)-coated glass slides were purchased from Bruker Daltonics (Bremen, Germany). Adhesive slides SuperFrost Plus^TM were obtained from Thermo Fisher Scientific (Waltham, Massachusetts, USA) for histological analysis. Trifluoroacetic acid (TFA) and 1,5-diaminonaphtalene (1,5-DAN, ≥97.0%) MALDI matrix were purchased from Sigma-Aldrich (St. Louis, MO). 4-phenyl-α-cyanocinnamic acid amide (PhCCAA) matrix was obtained from SiChem (Bremen, Germany). Acetonitrile (ACN) was obtained from VWR (Darmstadt, Germany). For external calibration of the Bruker solarix magnetic resonance mass spectrometer (MRMS), a mixture of poly-DL-alanine (10 mg/mL), L- alanine ≥ 99.5% (5 mg/mL), and taurine ≥ 99% (5 mg/mL; all from Sigma-Aldrich) was used in water.

All reagents were of HPLC or cell culture grade. Lipopolysaccharide from Escherichia coli O55:B5 (LPS, Cat. No. L2880) was purchased from Sigma-Aldrich (Taufkirchen, Germany). Phosphate buffer saline (PBS; Biowest, Cat. No. L0615), Acetonitrile (ACN; Merck, Cat. No. 100030), Trifluoracetic acid (TFA; Merck, Cat.Nno. 108262), 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazoliumbromid (MTT; PanReac AppliChem, Cat. No. A2231) and Dimethylsulfoxide (DMSO; Cat. No. 23500260) were purchased from VWR International (Darmstadt, Germany). Milli-Q water (ddH₂O; Millipore) was prepared in-house. Mouse IL-6 and TNF-α ELISA kits (Cat. No. 900-TM50 and 900-TM54) were obtained from PeproTech GmbH (Hamburg, Germany). 2,5-dihydroxybenzoic acid (DHB; Cat. No. 8201346) was purchased from Bruker Daltonics (Bremen, Germany). Brain Total Lipid Extract (TBLE; Cat. No. 131101) was from Avanti Polar Lipids (Alabaster, USA). SAHA (suberoylanilide hydroxamic acid, Vorinostat; Cat. No. 10009929) was purchased from Cayman Chemical (Ann Harbor, USA). ESI-L LC/MS tuning mix (Cat. No. G1969-85,000) was from Agilent (Santa Clara, USA).

All reagents were of HLPC grade. Acetonitrile (ACN) and trifluoroacetic acid (TFA) were purchased from Merck (Darmstadt, Germany). Dimethylsulfoxide (DMSO; cell culture grade) was obtained from Sigma Aldrich (Munich, Germany). Milli-Q water (ddH₂O; Millipore) was prepared in-house. 2,5-Dihydroxybenzoic acid (DHB), 6-Aza-2-thiothymine (ATT) and the peptide MALDI-MS calibration standard mix (cat. no. # 8222570) were purchased from Bruker Daltonics (Bremen, Germany). Imatinib Free Base (Cat. No. I-5577), Dasatinib Free Base (Cat. No. D-3307), Nilotinib Free Base (Cat. No. N-8207), Vandetanib (Cat. No. V-9402), Sorafenib Free Base (Cat. No. S-8599) and Sunitinib Malate Salt (S-8803) were purchased from LC Laboratories (Woburn, USA); Chloroquine diphosphate salt (Cat. No. C6628) was obtained from Sigma-Aldrich. Olanzapine (Cat. No. S2493) and Romidepsin (Cat. No. S3020) were obtained from SelleckChem.