Micropet r4 camera

Manufactured by Siemens

Sourced in United States

The MicroPET R4 camera is a compact, high-resolution positron emission tomography (PET) imaging system designed for small animal research. It is capable of producing detailed images of small animals, such as mice and rats, to support various preclinical studies. The MicroPET R4 camera utilizes advanced detector technology to capture and record the distribution of positron-emitting radiopharmaceuticals within the subject, providing researchers with valuable data for their investigations.

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Lab products found in correlation

Isoflurane, by Baxter (2 mentions)

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R4 microPET (5 citations)

2 protocols using micropet r4 camera

Evaluating Neu-Targeted PET Imaging Agents

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BALB NeuT mice bearing spontaneous mammary tumors were injected i.v. in the lateral tail vein with [⁶⁴Cu]Cu-NOTA-α-Neu (∼180–240 μCi/mouse, 42.8–57.1 μg in 150 μL sterile saline, clone 7.16.4) or control [⁶⁴Cu]Cu-NOTA-IgG.¹⁰⁵ (link) Imaging was acquired from 4 to 72 hours post injection (p.i.). The animals were anesthetized with 3-5% isoflurane (Baxter Healthcare) in air for induction, then lowered to 1.5% to 2% for maintenance. Images were acquired with a microPET R4 camera (Siemens Medical Solutions, USA, formerly Concorde Microsystems). Manually drawn three-dimensional volumes of interest (VOI) were selected to determine maximum and mean percent injected dose per gram (%ID/g) in target tissues. Images were decay-corrected to the time of injection and analyzed for tracer uptake using ASIpro VMTM software v. 6.3.3.0.

Jacob J.B., Wei K.C., Bepler G., Reyes J.D., Cani A., Polin L., White K., Kim S., Viola N., McGrath J., Guastella A., Yin C., Mi Q.S., Kidder B.L., Wagner K.U., Ratner S., Phillips V., Xiu J., Parajuli P, & Wei W.Z. (2023). Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model. iScience, 26(4), 106320.

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Radiotracer Biodistribution in Tumor-Bearing Mice

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Tumor-bearing animals were injected intravenously (i.v.). with the radiolabeled antibody (~180–240 μCi/mouse, 42.8 – 57.1 μg in 150 μL sterile saline) in the lateral tail vein. Imaging was acquired from 4–72 h post-injection (p.i.). The animals were anesthetized with 3–5% isoflurane (Baxter Healthcare, Deerfield, IL) in air for induction, then lowered to 1.5–2% for maintenance. Images were acquired with a microPET R4 camera (Siemens Medical Solutions, USA formerly Concorde Microsystems). Manually drawn 3-dimensional volumes-of-interest (VOI) were selected to determine maximum and mean percent injected dose per gram (%ID/g) in various tissues. Images were decay-corrected to the time of injection and analyzed for tracer uptake using ASIpro VMTM software v. 6.3.3.0.

Gibson H.M., McKnight B.N., Malysa A., Dyson G., Wiesend W., McCarthy C.E., Reyes J., Wei W.Z, & Viola-Villegas N.T. (2018). Interferon-γ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy. Cancer research, 78(19), 5706-5717.

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