In all cases, patients were injected intravenously with 3.7 MBq/kg of 18F-FMISO. A 20-minute static 18F-FMISO PET emission image was acquired at about 120 minutes after injection of 18F-FMISO. PET scans were performed on two devices, both of which were calibrated. On a CTI EXACT HR+ scanner and a Siemens Biograph40 mCT scanner as previously described (8 (link)). The tumor ROIs on the 18F-FMISO PET images included all regions where there was FMISO uptake, and two 2 cm diameter ROIs on both sides of the cerebellar cortex were used as the image derived blood surrogate to determine the surrogate of tissue to blood ratio (TB ratio). HV was determined by the number of pixels with TB ratio above 1.2.
Biograph40 mct scanner
Manufactured by Siemens
Sourced in Germany
The Biograph40 mCT scanner is a medical imaging device designed for Positron Emission Tomography (PET) and Computed Tomography (CT) imaging. The scanner combines high-resolution PET and CT technologies to capture detailed images of the human body. The core function of the Biograph40 mCT is to provide healthcare professionals with accurate diagnostic information to support patient care.
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Lab products found in correlation
3 protocols using biograph40 mct scanner
1
Quantifying Hypoxia with 18F-FMISO PET
2
Amyloid PET Imaging in Dementia Diagnosis
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At the VUmc, amyloid PET scans are made with 3-Tesla Philips Ingenuity TF PET/MR, Philips Ingenuity TF PET/CT and Philips Gemini TF PET/CT scanners. UMCU uses a Siemens Biograph 40 MCT scanner. Before and after scanning, patients fill out a questionnaire regarding their expectations and perceptions of amyloid PET. Patients are injected with a tracer dose of approximately 300 MBq ± 20% 18F-florbetaben (NeuraceqTM). The image acquisition window extends from 90 to 110 minutes (4 × 5-minute frames) after dose injection. PET scans are collected centrally at the VUmc and visually assessed by an experienced nuclear physician (B.V.B.) for amyloid positivity (yes/no).
For each patient, a preamyloid and postamyloid PET diagnosis is obtained with a level of confidence indicated by the neurologist (F.B. at the VUmc and G.J.B. at the UMCU) varying from 0%–100%. Also, the neurologists are asked about patient management before and after amyloid PET scan results are revealed, to assess a change in ancillary investigations, care, and medication.
For each patient, a preamyloid and postamyloid PET diagnosis is obtained with a level of confidence indicated by the neurologist (F.B. at the VUmc and G.J.B. at the UMCU) varying from 0%–100%. Also, the neurologists are asked about patient management before and after amyloid PET scan results are revealed, to assess a change in ancillary investigations, care, and medication.
3
Periodontal Inflammation Assessment via PET
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After adhering to a 24 h low-carbohydrate diet and 6 h of fasting, participants underwent 2’-deoxy-2’-[18F]fluoro-D-glucose positron emission tomography ([18F]FDG PET) (Appendix A ) with low-dose noncontrast-enhanced CT on a dedicated Siemens Biograph 40 mCT scanner (Siemens Healthineers, Erlangen, Germany). Analyses were performed on reconstruction settings according to European guidelines [35 (link)] using Inveon Research Workspace v4.2 software. See Supplementary Materials for details.
Periodontal tissue inflammation was determined by the [18F] FDG-uptake in the left and right periodontium of maxilla-to-mandible. The mean standardized uptake value (SUVmean) was calculated after correction for weight and [18F] FDG-dose (MBq).
Periodontal tissue inflammation was determined by the [18F] FDG-uptake in the left and right periodontium of maxilla-to-mandible. The mean standardized uptake value (SUVmean) was calculated after correction for weight and [18F] FDG-dose (MBq).
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