Ly2886721

Manufactured by Selleck Chemicals

LY2886721 is a chemical compound used in laboratory research and experiments. It serves as a tool for researchers to study and investigate various scientific inquiries. The core function of LY2886721 is to facilitate controlled experiments and analysis within a laboratory setting.

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3 protocols using ly2886721

Investigating Alzheimer's Pathogenesis with LY-2886721

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LY‐2886721 (Selleck Chemicals) was prepared fresh from frozen stocks before administration and was dissolved in the differentiation medium, at 5 µmol/L as working concentration, as described previously.²⁷, ²⁸ Then, we treated the 6‐week‐differentiated iPSC‐derived neurons with LY‐2886721 for 5 days and investigated the effects on Aβ and p‐Tau levels.

Li L., Kim H.J., Roh J.H., Kim M., Koh W., Kim Y., Heo H., Chung J., Nakanishi M., Yoon T., Hong C.P., Seo S.W., Na D.L, & Song J. (2020). Pathological manifestation of the induced pluripotent stem cell‐derived cortical neurons from an early‐onset Alzheimer's disease patient carrying a presenilin‐1 mutation (S170F). Cell Proliferation, 53(4), e12798.

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Amyloid-β Inhibitor Screening Protocol

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LY2886721, LY2811376, AZD3293, AZD3839, MK-8931, Pepstatin A, TAPI-1, Batimastat and DAPT were from Selleckchem; E2609 was from Sun-Shine Chemical; PF-06751979 was from MedChemExpree; β-secretase inhibitor IV was from Millipore; GI 254023X was from TOCRIS; Roburic acid was from Aobious; synthetic β-amyloid peptides are all from Anasepc; and recombinant human BACEl and BACE2 protein was from R&D system.

Liu L., Lauro B.M., Ding L., Rovere M., Wolfe M.S, & Selkoe D.J. (2019). Multiple BACE1 Inhibitors Abnormally Increase the BACE1 Protein in Neurons by Prolonging its Half-life. Alzheimer's & dementia : the journal of the Alzheimer's Association, 15(9), 1183-1194.

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Inhibition of ADAM Proteases in Cells

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Inhibitors LY2886721, Lanabecestat, and Marimastat were from Selleck Chemicals and TMI-1 was from Tocris Sciences. Anti-ADAM17 and anti-ADAM9 were from Cell Signaling Technology (Cat:3976S and 4151S, 1:000 dilution), anti-BACE2 antibody was from Santa Cruz Biotechnology (sc-271212, 1:1000 dilution), and anti-MSLN antibody (mouse monoclonal MN, 1 ug/ml) was from our lab. siRNAs against human ADAM17: s13719 (siADAM17_1) and si13720 (siADAM17_2) and one siRNA targeting ADAM10: s1004 were from Thermo Fisher Scientific. All other On-Target Plus siRNA and negative control siRNA luciferase GL2 were from Dharmacon.

Liu X., Chan A., Tai C.H., Andresson T, & Pastan I. (2020). Multiple proteases are involved in mesothelin shedding by cancer cells. Communications Biology, 3, 728.

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