Inveon pet spect ct

Manufactured by Siemens

Sourced in United States

The Inveon PET/SPECT/CT is a multimodal imaging system that combines Positron Emission Tomography (PET), Single-Photon Emission Computed Tomography (SPECT), and Computed Tomography (CT) technologies. It is designed to enable high-resolution, non-invasive imaging of small animals for research purposes.

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Lab products found in correlation

Oct compound, by Sakura Finetek (1 mentions) Inveon research workplace software, by Siemens (1 mentions) Cobra exxim, by Siemens (1 mentions)

Close spelling variants of this product

Inveon Micro-PET/SPECT/CT Inveon micro-CT/SPECT/PET system Inveon Small Animal PET/SPECT/CT scanner Inveon PET/SPECT/CT scanner Inveon trimodality PET/SPECT/CT scanner Inveon Docked PET/SPECT/CT Inveon PET/CT Inveon PET Inveon

5 protocols using inveon pet spect ct

Small Animal Micro-CT Imaging Protocol

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Micro‐computed tomography (CT) examinations were performed on a special small animal scanner (Inveon PET/SPECT/CT; Siemens) in the Core Facility Small Animal Imaging of DKFZ. The mice were anesthetized with sevoflurane (2.5% vol/vol) for immobilization. The total anesthetic duration per mouse was less than 60 minutes.

Alikhanyan K., Chen Y., Kraut S, & Sotillo R. (2020). Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma. Immunity, Inflammation and Disease, 8(2), 181-187.

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Histological Analysis of Carotid Arteries

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Twenty CEA tissues, 13 right (Rt) and 7 left (Lt) were scanned with a high-resolution micro-computed tomography (CT) (Inveon PET/Spect/CT, Siemens, PA, USA) using Inveon Research Workplace software (Siemens, Malvern, PA; additional details can be found elsewhere (11 (link))). The tissues were frozen in OCT compound (Sakura Finetek, Torrance, CA). The micro-CT images were used to guide the selection of frozen sections (10μm thick). Representative locations (internal/external, bulb and common segments) of the CEA tissues were collected. Depending on the size and extent of calcification, 5 to 10 different representative locations were selected along each tissue. Serial cross sections in that particular location were cut and stained with von Kossa’s reagent for calcium phosphate, Masson’s Trichrome reagent to distinguish collagen from fibrin, and Oil Red O reagent for lipids (Figure 1).

Han R.I., Wheeler T.M., Lumsden A.B., Reardon M.J., Lawrie G.M., Grande-Allen J.K., Morrisett J.D, & Brunner G. (2016). Morphometric analysis of calcification and fibrous layer thickness in carotid endarterectomy tissues. Computers in biology and medicine, 70, 210-219.

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Quantitative Analysis of Femoral Trabecular Microarchitecture

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The trabecular microarchitectures of the distal femoral metaphysis were analysed using SIEMENS Inveon PET.SPECT.CT (SIEMENS, Berlin, Germany). The femurs were harvested and preserved in 70% ethanol. The region of interest (ROI) was defined as a region 25–125 slices from the distal femoral growth plate. The thickness of a slice was 21 μm, and the voxel resolution was 22 μm 3 (link). Quantitative analyses of trabecular morphometric parameters, such as trabecula thickness (Tb.Th), trabecula number (Tb.N), trabecular separation (Tb.Sp), bone surface over bone volume (BS/BV) and bone volume to tissue volume (BV/TV), were conducted in VOI using the associated software package, with 3D images of the distal femurs reconstructed for visualization. All of the analyses were conducted by a blinded performer who did not know the treatments that the specimens received.

Ma X., Lv J., Sun X., Ma J., Xing G., Wang Y., Sun L., Wang J., Li F., Li Y, & Zhao Z. (2016). Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone. Scientific Reports, 6, 24562.

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Femur Morphological Analysis via Preclinical PET/SPECT/CT

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To evaluate morphological status in femurs, a Siemens preclinical Inveon PET/SPECT/CT (Siemens Medical Solutions USA, Knoxville, TN, USA) was utilized. The spatial resolution was set to 8.5 μm with a voxel size of 17.2× 17.2 × 17.2 (μm), and the tube voltage and current is 80 kV and 500 μA, respectively. The resolution was set to medium (1000 projections each), increment were set to 17.2 μm, and the region of interest area was 0.225 mm proximal to the growth plate, that is,100–250 layer proximal to the butterfly area. Three-dimensional imaging was performed using COBRA Exxim (licensed to Siemens). Morphological analysis was carried out using a Inecon Research Workplace, and various trabecular bone parameters were recorded, including bone specific surface (BS/BV; 1/mm), bone volume fraction (BV/TV; %), trabecular thickness (Tb.Th; μm), trabecular number (Tb.N; 1/mm), trabecular separation (Tb.Sp; μm) and trabecular bone pattern factor (Tb.Pf; 1/mm). The cross-sectional moment of inertia (CSMI) at the lower-middle third of the femur was also measured.

Zhao B., Zhao W., Wang Y., Zhao Z., Zhao C., Wang S, & Gao C. (2018). Prior administration of vitamin K2 improves the therapeutic effects of zoledronic acid in ovariectomized rats by antagonizing zoledronic acid-induced inhibition of osteoblasts proliferation and mineralization. PLoS ONE, 13(8), e0202269.

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Structural Analysis of Murine Knee Subchondral Bone

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Excess muscle tissues were removed from the entire right knee joint of the mice and fixed in 10% formalin overnight. The specimens were scanned using a microcomputer (Inveon PET.SPECT.CT, Siemens). The images were scanned (Inveon Acquisition Workplace), reconstructed (COBRA_Exxim, Siemens), and further analyzed using the calculation software (Ineon Research Workplace). The X-ray current and voltage were set to 500 μA and 80 kV, respectively, and the resolution was 8.5 μm/μm/pixel. The sagittal view of the entire medial compartment of the tibial subchondral bone was used for the 3D histomorphometry analysis, and the parameters of bone volume/total tissue volume (BV/TV), subchondral bone plate thickness (SBP.Th), and trabecular separation (Tb.Sp) were analyzed.

Zhao X., Ma L., Guo H., Wang J., Zhang S., Yang X., Yang L, & Jin Q. (2022). Osteoclasts secrete leukemia inhibitory factor to promote abnormal bone remodeling of subchondral bone in osteoarthritis. BMC Musculoskeletal Disorders, 23, 87.

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