2 3 4 dichlorophenyl n methyl n 1r 2r 2 pyrrolidin 1 ylcyclohexyl acetamide u50 488

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2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide (U50,488) is a synthetic organic compound. It functions as a selective kappa opioid receptor agonist.

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Lab products found in correlation

3h damgo, by PerkinElmer (2 mentions) Forskolin, by Merck Group (2 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Leu enkephalin, by Merck Group (1 mentions) 3h dpdpe, by PerkinElmer (1 mentions) 2s 2 2 2r 2 2s 2 amino 3 4 hydroxyphenyl propanoyl amino propanoyl amino acetyl methylamino n 2 hydroxyethyl 3 phenylpropanamide damgo, by Bio-Techne (1 mentions) Morphine sulfate pentahydrate, by Merck Group (1 mentions)

3 protocols using 2 3 4 dichlorophenyl n methyl n 1r 2r 2 pyrrolidin 1 ylcyclohexyl acetamide u50 488

Molecular Probes for Pain Research

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Forskolin, dimethyl sulfoxide (DMSO) and ethyl alcohol (200 proof) were purchased from Millipore-Sigma (St. Louis, MO, USA). 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide (U50,488) was purchased from Tocris Bioscience (Bio-techne Corporation, Minneapolis, MN, USA). (2E)-N-[(5α,6β)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]-3-(3-furyl)-N-methylacrylamide hydrochloride (Nalfurafine/nalfurafine) was obtained from AdooQ Bioscience (Irvine, CA, USA). 3-(2-((Cyclopropylmethyl)(phenethyl)amino)ethyl)phenol hydrochloride (HS666) was obtained from Axon Medchem LLC (Groningen, Netherlands).

French A.R., Gutridge A.M., Yuan J., Royer Q.H, & van Rijn R.M. (2022). Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumption. Pharmacology, biochemistry, and behavior, 216, 173377.

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Radioligand Binding Assay Protocol

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Forskolin and DMSO were purchased from Sigma-Aldrich (St. Louis, MO, United States).(2S)-2-[[2-[[(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2hydroxyethyl)-3-phenylpropanamide (DAMGO), and 2-(3,4-dichlorophenyl)-Nmethyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl] acetamide (U50,488) were purchased from Tocris Bioscience (Bio-Techne Corporation, Minneapolis, MN, United States). [³H]DAMGO (53.7 Ci/mmol, lot#2376538; 51.7 Ci/mmol, lot#2815607), [3H]U69,593 (60 Ci/mmol, lot#2367921 and lot#2644168; 49.2 Ci/mmol, lot#2791786), were purchased from PerkinElmer (Waltham, MA, United States).

Hennessy M.R., Gutridge A.M., French A.R., Rhoda E.S., Meqbil Y.J., Gill M., Kashyap Y., Appourchaux K., Paul B., Wang Z.J., van Rijn R.M, & Riley A.P. (2023). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of medicinal chemistry, 66(5), 3312-3326.

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Opioid Receptor Ligand Binding Assay

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Leu-enkephalin, forskolin, and morphine sulfate pentahydrate were purchased from Sigma Aldrich (St. Louis, MO, USA). (2S)-2-[[2-[[(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino] propanoyl] amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide (DAMGO), and 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide (U50,488) were purchased from Tocris Bioscience (Bio-techne Corporation, Minneapolis, MN, USA). [³H]DAMGO (49.2 Ci/mmole, lot#2573313), [³H]U69,593 (60 Ci/mmole, lot#2367921), and [³H]DPDPE (53.7 Ci/mmole, lot#2376538) were purchased from Perkin Elmer (Waltham, MA, USA).

Creed S.M., Gutridge A.M., Argade M.D., Hennessy M.R., Friesen J.B., Pauli G.F., van Rijn R.M, & Riley A.P. (2020). Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. Journal of natural products, 84(1), 71-80.

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