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Carboplatin

Manufactured by MP Biomedicals
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Carboplatin is a platinum-based chemotherapy medication used in the treatment of various types of cancer. It functions as an antineoplastic agent, inhibiting the growth and division of cancer cells. The core function of Carboplatin is to disrupt the cell division process, thereby preventing the proliferation of cancerous cells.

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Lab products found in correlation

Doxycycline, by Takara Bio (2 mentions) Cd11b, by BD (1 mentions) Trimethoprim, by Merck Group (1 mentions) Igg2b isotype control clone ltf 2, by BioXCell (1 mentions) Sulfamethoxazole, by Merck Group (1 mentions) Gsk2033, by Merck Group (1 mentions) β estradiol, by MP Biomedicals (1 mentions) Lc ms grade acetonitrile, by Merck Group (1 mentions) Ethyl acetate hplc grade, by Merck Group (1 mentions) Methanol, by Merck Group (1 mentions) Ammonium formate, by Merck Group (1 mentions) Ondansetron, by LGC (1 mentions) Ifosfamide, by Merck Group (1 mentions) Etoposide, by MP Biomedicals (1 mentions) Methotrexate, by MP Biomedicals (1 mentions) Whatman, by Cytiva (1 mentions)

4 protocols using carboplatin

1

Dual Doxycycline and Carboplatin Murine Protocol

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Doxycycline (Clontech 631311) was administered to mice in water, using 5% sucrose as the vehicle. 2 mg/ml Doxycycline solution was freshly prepared twice a week. Carboplatin (MP Biomedicals 198873) was resuspended in 0.9% NaCl and i.p. injected into mice once a week, at a concentration of 50 mg/kg.
Knezevic J., Pfefferle A.D., Petrovic I., Greene S.B., Perou C.M, & Rosen J.M. (2015). Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential. Oncogene, 34(49), 5997-6006.
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2

Murine Cholesterol Diet Protocols

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HCD (high cholesterol diet, 2% cholesterol and 0.5% sodium cholate) and CD (control diet, 0.5% sodium cholate) were purchased from TestDiet (5CNY and 5BRW). 27HC and GW273297X were synthesized by Sai Life (Hyderabad, India). GSK 2033 (cat#1221277-90-2), sulfamethoxazole (cat#723-46-6) and trimethoprim (cat#738-70-5) were purchased from Sigma-Aldrich. ICI 182,780 was synthesized by Small Molecule Incorporated (Beijing, China). LDL cholesterol was purchased from Lee Biosolutions (lot#W21129, cat#360–10). 17 β-Estradiol (cat#101656) and carboplatin (lot#M9733, cat#198873) were obtained from MP Biomedicals. Anti-PD-L1 (clone 10F.962, lot#615416D1, cat#BE0115) and IgG2b isotype control (Clone LTF-2, cat#BE0090) were purchased from BioXCell. Flow cytometry antibodies were from BD Pharmingen: CD11b (Cat #557686), Ly6C (Cat #553104), Ly6G (Cat #551461), CD3 (Cat #555275), CD4 (Cat #553729), CD8 (Cat #557682), CD44 (Cat#553134), CD69 (Cat#557392). Recombinant mouse GM-CSF (Cat #P01587) and ID6 (Cat #P08505) were purchased from Novoprotein.
He S., Ma L., Baek A.E., Vardanyan A., Vembar V., Chen J.J., Nelson A.T., Burdette J.E, & Nelson E.R. (2019). Host CYP27A1 expression is essential for ovarian cancer progression.. Endocrine-related cancer, 26(7), 659-675.
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3

Quantitative Analysis of Chemotherapeutic Agents

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Ifosfamide and cyclophosphamide monohydrate pure standards were purchased from Sigma-Aldrich Co® (St. Louis MO, USA) and MP Biomedicals® (Fountain Pkwy, Solon OH, USA), respectively. Standards of etoposide, carboplatin, vincristine sulphate and methotrexate were all purchased from MP Biomedicals® (Fountain Pkwy, Solon OH, USA), and ondansetron from Toronto Research Chemicals Inc® (Toronto, Canada).
LC-MS grade acetonitrile and methanol were obtained from EMD Millipore Co® (Venezuela), HPLC grade ethyl acetate from Merck® (Darmstat, Germany) and propanol from J.T. Baker® (Xalostoc, Mexico). Ammonium formate was purchased from Sigma Adrich® (St. Louis MO, USA). Whatman 903® cotton filter paper (“Guthrie” cards) were bought from GE Healthcare Ltd.® (Cardiff, UK). Milli-Q grade 1 water (Millipore, Molsheim, France) was used to prepare all the solutions and dilutions.
Torres L.M., Rivera-Espinosa L., Chávez-Pacheco J.L., Navas C.F., Demetrio J.A., Alemón-Medina R., Trujillo F., Pérez M., Zapata M.M., Cárdenas R., Salinas C., Aquino A., Velázquez-Cruz R, & Castillejos M.D. (2015). A New Method to Quantify Ifosfamide Blood Levels Using Dried Blood Spots and UPLC-MS/MS in Paediatric Patients with Embryonic Solid Tumours. PLoS ONE, 10(11), e0143421.
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4

Dual Doxycycline and Carboplatin Murine Protocol

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Doxycycline (Clontech 631311) was administered to mice in water, using 5% sucrose as the vehicle. 2 mg/ml Doxycycline solution was freshly prepared twice a week. Carboplatin (MP Biomedicals 198873) was resuspended in 0.9% NaCl and i.p. injected into mice once a week, at a concentration of 50 mg/kg.
Knezevic J., Pfefferle A.D., Petrovic I., Greene S.B., Perou C.M, & Rosen J.M. (2015). Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential. Oncogene, 34(49), 5997-6006.
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