Cobas vitamin d3 assay

Manufactured by Roche

Sourced in Germany

The Cobas® Vitamin D3 assay is a laboratory diagnostic product manufactured by Roche. It is used to measure the level of 25-hydroxyvitamin D3 in human blood samples. The assay provides quantitative results for the assessment of vitamin D3 status.

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3 protocols using cobas vitamin d3 assay

Serum Biomarker Analysis via ELISA

Cited 3 times

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The concentrations of serum biomarkers were determined using enzyme-linked immunosorbent assay kits (adiponectin, Boster, Pleasanton, CA, United States; leptin, Boster, Pleasanton, CA, United States; high-sensitivity C-reactive protein (HS-CRP), Roche, Basel, Switzerland; TNF-α, Immunite 1000 LKNF1, Siemens Medical Solutions Diagnostics, Llanberis, UK) [24 (link),25 (link)]. The serum level of 25(OH)D was measured using an electro-chemiluminescence immunoassay (Cobas® Vitamin D3 assay, Roche Diagnostics GmbH, Mannheim, Germany) with an interassay coefficient of variation of 2.2–13.6% [19 (link)]. Each biomarker assay was performed in duplicate according to the manufacturer’s instructions, and the mean value was used for further statistical analysis.

Fang W.C., Chen H.Y., Chu S.C., Wang P.H., Lee C.C., Wu I.W., Sun C.Y., Hsu H.J., Chen C.Y., Chen Y.C., Wu V.C, & Pan H.C. (2022). Serum Cystatin C Levels Could Predict Rapid Kidney Function Decline in A Community-Based Population. Biomedicines, 10(11), 2789.

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Serum 25(OH)D Measurement by ECLIA

Cited 1 time

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Serum level of 25(OH)D was measured using an electro-chemiluminescence immunoassay (Cobas^® Vitamin D3 assay, Roche Diagnostics GmbH, Mannheim, Germany) with an interassay coefficient of variation of 2.2–13.6% (19 (link)).

Chu S.C., Wang P.H., Lu K.Y., Ko C.C., She Y.H., Lee C.C., Wu I.W., Sun C.Y., Hsu H.J, & Pan H.C. (2022). Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study. Frontiers in Public Health, 10, 895787.

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Dialysis Treatment Adequacy and Laboratory Profiles

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We got whole laboratory data and dialysis-related parameters for patients in both groups. The laboratory profiles included the hemoglobin, plasma levels of albumin, blood urea nitrogen (BUN), creatinine, hs-CRP, calcium, phosphate, i-PTH, and cholesterol. Besides, parameters reflecting urea clearance, including Kt/V value (Daugirdas) and URR were evaluated to determine the dialysis treatment adequacy. Blood samples were collected and performed according to the recommended procedures by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative guidelines. Plasma levels of hemoglobin, BUN, creatinine, hs-CRP, albumin, cholesterol, calcium, and phosphate were determined by spectrophotometric analysis by using the modified kinetic Jaffe reaction. Plasma i-PTH levels were evaluated by a commercially available radioimmunoassay kit (Scantibodies Laboratory; Santee, CA, USA). 25-OH vitamin D was measured at the initial assessment by electrochemiluminescence immunoassay (Cobas® Vitamin D3 assay by Roche Diagnostics GmbH, Mannheim, Germany) with an inter-assay coefficient of variation of 2.2–13.6% from blood samples drawn before the beginning of dialysis session.

Hsu H.J., Wu I.W., Hsu K.H., Sun C.Y., Chen C.Y, & Lee C.C. (2020). Vitamin D deficiency, cardiothoracic ratio, and long-term mortality in hemodialysis patients. Scientific Reports, 10, 7533.

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