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Doxorubicin hydrochloride

Manufactured by MedKoo Biosciences
Sourced in United States

Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic. It is used as a chemotherapeutic agent.

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2 protocols using doxorubicin hydrochloride

1

PLA-Based Drug Delivery System

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Poly(lactic acid) (PLA) resin (Ingeo 4043D, 98% l-lactide, with weight average molecular weight of 111 kg mol−1 (ref. 30 (link))) was purchased from NatureWorks (Minnetonka, MN, USA). Dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Doxorubicin hydrochloride (99%, Dox-HCl) and doxorubicin free base (99%, Dox-base) were purchased from MedKoo Biosciences (Morrisville, NC, USA). Proteinase K (isolated from Tritirachium album) was purchased from Bio Basic (Amherst, NY, USA). Phosphate buffered saline (PBS, pH 7.4) and Tris–HCl buffer (pH 8.0) were purchased from Thermo Fisher (Waltham, MA, USA), and other chemicals were purchased from Fisher Scientific (Hampton, NH, USA) unless otherwise stated.
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2

Doxorubicin-loaded PLA/PVP Nanocomposites

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Polylactic acid (PLA) resin (Ingeo 4043D, NatureWorks), 98% L-lactide, with weight average molecular weight of 111 kg/mol was purchased from NatureWorks (Minnetonka, MN, USA). Polyvinylpyrrolidone (PVP) with average molecular weight of 1300 kg/mol was purchased from Alfa Aesar (Haverhill, MA, USA). Dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Doxorubicin hydrochloride (99%, Dox-HCl) was purchased from MedKoo Biosciences (Morrisville, NC, USA). Solvents, phosphate buffered saline (PBS, pH 7.4) were purchased from Thermo Fisher (Waltham, MA, USA), and other chemicals were purchased from Fisher Scientific (Hampton, NH, USA).
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