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Modular advanced rheometer system

Manufactured by Thermo Fisher Scientific
Sourced in United States

The Modular Advanced Rheometer System is a laboratory instrument designed for the measurement and analysis of the rheological properties of materials. It provides precise control and measurement of shear stress, shear rate, and viscosity for a wide range of sample types.

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4 protocols using modular advanced rheometer system

1

Characterization of Docetaxel-Loaded Nanoparticles

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Dynamic light scattering and zeta potential measurements were implemented via a Malvern Zetasizer Nano ZS Instrument. SEM imaging was constructed by a Quanta 200 SEM (Quanta 200). G′ and G″ were measured by Modular Advanced Rheometer System (Thermo Fisher Scientific HAAKE MARS, MA, USA).
The sustaining release solutions were collected in different time points under 6 ml of saline. Furthermore, the docetaxel amount in NPs and release solution was quantified by HPLC (Agilent Technologies 1260 Infinity), which is equipped with reverse-phase HPLC column (Sepax GP-C18). The acetonitrile/water (42:58, v/v) mixture was used as a mobile phase, and the flow rate was 1 ml/min and then detected with an ultraviolet at 270 nm.
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2

Rheological Characterization of Refined Creams

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The rheological behaviour of refined creams was determined by a Modular Advanced Rheometer System (Haake MARS, Thermo Scientific, Waltham, MA, USA), equipped with a vane tool geometry (diameter 22 mm, length 16 mm, gap = 1 mm, ≈ 28 mL of the sample). Strain sweep tests (strain ranging from 0.0001 to 10%, frequency = 1 Hz) were carried out to define the LVR and to determine the yield stress. Frequency sweep tests (frequency ranging from 0.1 to 10 Hz, γ= 0.0005%) were performed to investigate the time-dependent deformation behaviour of the creams. The viscosity curves were measured as a function of the increasing shear rate (0.1–100 s−1) at 25 °C. The measurements were conducted in triplicate.
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3

Rheological Characterization of Samples

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The rheological properties of the samples were determined by a Modular Advanced Rheometer System (Haake MARS, Thermo Scientific, Waltham, MA, USA), equipped with a vane tool geometry (diameter = 22 mm, length = 16 mm, distance = 8.5 mm). Transient tests were carried out, and to this end, the stress (τ, Pa) was measured as a function of time (60 s), keeping the shear rate constant (ɣ = 10 s−1). The flow curves were carried out at 30.5 °C, as an arithmetic average of room and mouth temperatures, according to the method proposed by [35 (link)]. Three replications for each sample were performed. Results were used to produce a shear stress growth function and to collect stress overshoot values [36 ].
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4

Rheological Analysis of Thermosensitive Hydrogels

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The thermosensitive behaviour of the PEG-PCL-PEG hydrogel and PEG-PCL-PEG/PLU mixture was rheologically analysed. The rheological measurements were investigated employing a Haake MARS, Modular Advanced Rheometer system (Thermoscientific, Dreieich, Germany). The instrument was pre-equipped with a thermo-bath that controlled the temperature of the sample chamber within the required value. In order to measure the gelation temperature of the copolymer solution, temperature sweep analysis was performed at 1 Hz, at a rate of temperature increase of 1 °C/min between 10–60 °C. The dynamic viscoelastic property such as the shear storage modulus (G’) was measured as a function of temperature for different concentrations of the hydrogel formulation.
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