Ciita ko

Manufactured by Jackson ImmunoResearch

Sourced in United States

The CIITA KO product is a genetically engineered cell line that lacks the expression of the CIITA (Class II Transactivator) gene. CIITA is a key regulator of major histocompatibility complex (MHC) class II gene expression. The CIITA KO cell line can be used as a research tool to study MHC class II-related biological processes.

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Lab products found in correlation

2 protocols using ciita ko

Mouse Models for Immunological Research

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C57BL/6 mice were purchased from Charles River. HOD mice were generated as previously described (Desmarets et al., 2009 (link); Hendrickson et al., 2011 (link)); UBC-GFP, BATF3 KO, CIITA KO, CD11c-Cre, and IRF4^fl/fl mice were purchased from The Jackson Laboratory. OT-II mice were purchased from the The Jackson Laboratory and bred with wild-type CD45.1 mice in our facility. All protocols used in this study were approved by Yale Institutional Animal Care and Use Committee.

Calabro S., Gallman A., Gowthaman U., Liu D., Chen P., Liu J., Krishnaswamy J.K., Nascimento M.S., Xu L., Patel S.R., Williams A., Tormey C.A., Hod E.A., Spitalnik S.L., Zimring J.C., Hendrickson J.E., Stowell S.R, & Eisenbarth S.C. (2016). Bridging channel dendritic cells induce immunity to transfused red blood cells. The Journal of Experimental Medicine, 213(6), 887-896.

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Mouse Strain Characterization for Research

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The Research Ethics Committee for Animal Use of the School of Pharmaceutical Sciences of Ribeirao Preto of the University of Sao Paulo approved the current study (22.1.233.60.2). The following mouse strains were purchased from the Jackson Laboratories (USA): Kit^W/sh (#012861), Kit^W/W-v (#100410), B2m knockout (KO; #002087), Ciita KO (#003239), Il6 KO (#002650), NOD (#001976), NOD-scidγ (#005557), C57BL/6J (#000664; named herein Kit^B6, B2mWT, or CiitaWT), BALB/cJ (#000651; named herein St2WT), C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ (#006567; named herein Kit^{B6-Tag(CAG-EGFP)}), and Rag1 KO (#002216). The St2KO mouse strain was developed and donated by Dr Andrew McKenzie.17 (link)

Sakita J.Y., Elias-Oliveira J., Carlos D., de Souza Santos E., Almeida L.Y., Malta T.M., Brunaldi M.O., Albuquerque S., Araújo Silva C.L., Andrade M.V., Bonato V.L., Garcia S.B., Cunha F.Q., Cebinelli G.C., Martins R.B., Matthews J., Colli L., Martin F.L., Uyemura S.A, & Kannen V. (2022). Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition. Journal for Immunotherapy of Cancer, 10(10), e004653.

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