A 50-mm applicator (Intrabeam™ system) and a 50-to 60-mm applicator (Axxent™ system) were inserted in the prostate bed of two cadavers. CT images were then acquired. Pelvic organs at risk (bladder and rectum) were delineated on the images. Dose distribution was calculated using a Monte Carlo simulation for the Intrabeam™ system (17 ) or using Brachyvision software (Varian medical systems, San Jose, CA, USA) for the Axxent™ system. Dose–volume histograms were computed. A dose of 12 Gy at 5 mm depth, corresponding to 20 Gy at the surface of the applicator, was prescribed, similar to that used for breast cancer IORT (16 (link)) and prostate bed IORT using electrons (10 (link), 11 (link)). The dose distribution was computed to calculate normal tissue complication probabilities (NTCP) for rectum and bladder using relevant radiobiological parameters (alpha/beta for rectum and bladder 5.4 and 7.5 Gy, respectively) using EBRT and HDR models similar to those outlined by Takam et al. (18 (link)).
Brachyvision software
Manufactured by Agilent Technologies
Sourced in United States
BrachyVision software is a tool designed for the planning and analysis of brachytherapy treatments. It provides functionalities for importing and analyzing medical images, defining target volumes and organs at risk, and generating treatment plans. The software is intended to assist healthcare professionals in the brachytherapy treatment planning process.
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Lab products found in correlation
3 protocols using brachyvision software
1
Intraoperative Radiotherapy Dose Modeling
2
Cesium-131 Brachytherapy for Surgical Tumor Bed
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In patients who underwent resection, 131Cs brachytherapy seeds were implanted at 0.5-1 cm distance, making sure that the tumor bed was covered by 80 Gy at 0.5 cm using a nomogram created in Variseed (Varian Medical System, Palo Alto, CA, USA) [27 (link)]. Median seed activity was 2.4 U (0.5 mCi/s). Median seed air kerma strength was 2.4 U (3.77 mCi apparent activity). Post implant dosimetry was analyzed using BrachyVision software (Varian Medical Systems, Palo Alto, CA, USA). The dosimetry and exposure rate have been previously reported by our institution in a prior study, with excellent dosimetric coverage and acceptable exposure rate to treating physicians and staff [23 (link)].
Briefly, after the resection of the tumor that needs to be implanted, the tumor bed (Clinical Target Volume-CTV) is identified and a 131Cs plaque (Figure 1 ) is placed on the tumor bed (planer implant). The implant is placed so that it covers the entire tumor bed and an additional 0.5 cm around the tumor bed. This means that V100 (volume of CTV receiving 100% prescribed dose) is at 100%. In addition, D90 (dose going to 90% clinical target volume) is also at least 100% of the prescription dose in all implants. As mentioned previously, our prescription dose was 80 Gy. This technique of 131Cs implant was performed as an open surgical procedure.
Briefly, after the resection of the tumor that needs to be implanted, the tumor bed (Clinical Target Volume-CTV) is identified and a 131Cs plaque (
3
Postimplantation Dosimetry and Tumor Monitoring
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Postoperative MR images and noncontrast thin-cut CT scans (0.8-1.2-mm slice thickness) for postimplantation dosimetry were typically obtained within 24 hours (Fig. 3). Dosimetry was performed using BrachyVision software (Varian Medical Systems, Inc.).
During the 1st year, follow-up visits and MR images for grade I and II tumors were typically obtained every 6 months; for grade III tumors, every 3 months. No patient was lost to follow-up.
During the 1st year, follow-up visits and MR images for grade I and II tumors were typically obtained every 6 months; for grade III tumors, every 3 months. No patient was lost to follow-up.
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