P s396 irf3 4d4g

Manufactured by Cell Signaling Technology

P-S396 IRF3 (4D4G) is a rabbit monoclonal antibody that recognizes phosphorylated serine 396 of human interferon regulatory factor 3 (IRF3). IRF3 is a transcription factor that plays a crucial role in the cellular innate immune response to viral infection.

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Lab products found in correlation

β actin ab8226, by Abcam (2 mentions) Rig 1 ss1a, by Enzo Life Sciences (2 mentions) P s172 tbk 1 d52c2, by Cell Signaling Technology (2 mentions) Tbk 1 3013s, by Cell Signaling Technology (2 mentions) Cycloheximide (chx), by Merck Group (1 mentions) Nh4cl, by Thermo Fisher Scientific (1 mentions) Mg132 m8699, by Merck Group (1 mentions) H 300, by Santa Cruz Biotechnology (1 mentions) Fl425, by Santa Cruz Biotechnology (1 mentions)

Close spelling variants of this product

P-IRF3 (85 citations) P-IRF3(S396) (5 citations)

2 protocols using p s396 irf3 4d4g

Antibody Reagents for Innate Immune Signaling

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Antibodies against IRF3 (FL-425), GST (Z-5), and RIG-I (H-300) were purchased from Santa Cruz Biotechnology. Antibodies against Flag (M2; Sigma), V5 (A190-220A; Bethyl Group), Strep (688202; BioLegend), MAVS (5-20337; Thermo Scientific), RIG-I (SS1A; Enzo Life Sciences), p-S172 TBK-1 (D52C2; Cell Signaling), TBK-1 (3013S; Cell Signaling), p-S396 IRF3 (4D4G; Cell Signaling), and β-actin (Ab8226; Abcam) were purchased from the indicated suppliers. MG132 (M8699; Sigma), cycloheximide (C4859; Sigma), NH₄Cl (12125-02-9; Fisher Chemical), and [α-³²P]ATP (BLU003H250UC; PerkinElmer) were purchased from the indicated suppliers.

Liu Y., Qin C., Rao Y., Ngo C., Feng J.J., Zhao J., Zhang S., Wang T.Y., Carriere J., Savas A.C., Zarinfar M., Rice S., Yang H., Yuan W., Camarero J.A., Yu J., Chen X.S., Zhang C, & Feng P. (2021). SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. mBio, 12(5), e02335-21.

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Antibody Sources for Cellular Signaling

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Antibody against UL37 was generated by Cocalico Biologicals, Inc. Antibodies against IRF3 (FL-425), GST (Z-5), and RIG-I (H-300) were purchased from Santa Cruz Biotechnology. Antibodies against FLAG (M2; Sigma), V5 (A190-220A; Bethyl Group), CAD (A1301-374A; Bethyl Group), PPAT (15401-1-AP; Proteintech), CTPS1 (15914-1-AP; Proteintech), MAVS (5-20337; Thermo Scientific), RIG-I (SS1A; Enzo Life Sciences), p-S172 TBK-1 (D52C2; Cell Signaling), TBK-1 (3013S; Cell Signaling), p-S396 IRF3 (4D4G; Cell Signaling), and β-actin (Ab8226; Abcam) were purchased from the indicated suppliers.

Huang H., Zhao J., Wang T.Y., Zhang S., Zhou Y., Rao Y., Qin C., Liu Y., Chen Y., Xia Z, & Feng P. (2021). Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication. mBio, 12(2), e00115-21.

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