Domitor

Manufactured by Zoetis

Sourced in United States

Domitor is a veterinary drug product used as a sedative and analgesic in animals. It contains the active ingredient medetomidine hydrochloride, which is an alpha-2 adrenoceptor agonist. Domitor can be administered by injection to induce a controlled state of sedation and analgesia in animals.

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Lab products found in correlation

Ge signa, by GE Healthcare (1 mentions) Ketaset, by Zoetis (1 mentions) Medetomidine, by Zoetis (1 mentions) Emeprid, by Ceva (1 mentions) Torbugesic, by Zoetis (1 mentions) Euthasol, by Virbac (1 mentions) Antisedan, by Zoetis (1 mentions) Ketamine hydrochloride, by Zoetis (1 mentions) Previcox, by Boehringer Ingelheim (1 mentions)

5 protocols using domitor

Canine Brain MRI Imaging Protocol

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Magnetic resonance imaging examinations were performed with the dogs under general anesthesia, using a 1.5-T MR scanner (GE Signa, 1.5T, GE healthcare). Anesthetic protocols were the following: medetomidine (0.01 mg/kg IM, Domitor, Zoetis) was used for premedication, alfaxalone (2.0 mg/kg IV, Alfaxan, Jurox Pty Ltd) for induction, and isoflurane (Ifran, Hana Pharm) for maintenance. Noninvasive blood pressure, oxygen saturation, heart rate, body temperature, and end-tidal carbon dioxide concentration were monitored during the anesthesia.
The dogs were positioned in sternal recumbency on an 8-channel phased-array knee coil. Spin-echo T2W, FLAIR, GM and WM selective single-slab 3D DIR images were obtained in transverse plane from each dog. Table 1 details the parameters that were used for each sequence. To reduce the acquisition time for 3D DIR sequences, number of excitations (NEX) was adjusted from 4 to 2. The acquisition time for each sequence was automatically recorded. After the examination, complications related to the anesthesia were monitored for 5 days in each dog.

Je M., Yang S., Lee D., Choi J, & Yoon J. (2023). Single-slab 3D double inversion recovery for magnetic resonance brain imaging in clinically healthy dogs. Frontiers in Veterinary Science, 10, 1156870.

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Experimental Induction of Filariasis in Mice

Cited 2 times

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Simultaneously, groups of female and male wildtype BALB/c mice were exposed to either: (i) a s.c. injection of 500 L3 in 100 µl RPMI-1640 medium isolated from Chrysops flies; (ii) 10,000 MF via the tail vein in 100 µl RPMI-1640 medium isolated from human peripheral blood [22 (link)], or (iii) 10 L4; (iv) 10 L5; and (v) 10 adult worms all isolated from infected-BALB/cRAG2γc^−/− mice. Whereas L4 were injected s.c. in 100 µl of RPMI-medium, L5 and adult stages were implanted as previously described [23 (link)]. In short, mice were anesthetized with ketamine (Ketaset, 70 mg/kg; Zoetis, Parsippany-Troy Hills Township, New Jersey, USA) and medetomidine (Domitor, 0.8 mg/kg; Zoetis), flanks were shaved, dosed with betadine and following a small incision, L5 or adult worms were implanted into the mice. The incised area was then sutured and a s.c. shot of penicillin (12.06 mg/ml) was administered based on mouse weight (i.e. 100 µl/20 g) at the back of the neck followed by 200 µl antiserdan to wake the mouse up.

Chunda V.C., Ritter M., Bate A., Gandjui N.V., Esum M.E., Fombad F.F., Njouendou A.J., Ndongmo P.W., Taylor M.J., Hoerauf A., Layland L.E., Turner J.D, & Wanji S. (2020). Comparison of immune responses to Loa loa stage-specific antigen extracts in Loa loa-exposed BALB/c mice upon clearance of infection. Parasites & Vectors, 13, 51.

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Feline Hookworm Infection Inoculation Protocol

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Cats of both studies received approximately 100 T. brevior L3 on SD 0 as described below. Animals were anesthetized with a combined intramuscular injection of 0.08 ml/kg body weight (BW) Domitor^® (1 mg/ml medetomidine HCl, Zoetis) and 0.075 ml/kg BW Ketamin 10%^® (100 mg/ml ketamine HCl, WDT). After deep anesthesia, the cat received 0.06 ml/kg BW Emeprid^® IM (5 mg/ml, metoclopramide HCl, CEVA) 15 min (Study 1) or a few minutes (Study 2) before inoculation to prevent vomiting or regurgitation. A stomach tube was inserted without (Study 1) or with a rigid endoscope (Study 2). The inoculum was applied via syringe directly into the stomach, the tube was flushed with tap water and pulled out after confirming that no inoculation suspension remained in the tube. All cats were observed for vomiting or regurgitation directly after inoculation for up to 1 h (± 10 min) post-infection.

Traversa D., Raue K., Ringeisen H., Blazejak K., Bisterfeld K., Di Cesare A., Colombo M., Böhm C., Strube C, & Pollmeier M. (2022). Efficacy of a spot-on combination containing 10% w/v imidacloprid and 1% w/v moxidectin for the treatment of troglostrongylosis in experimentally infected cats. Parasites & Vectors, 15, 66.

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Longitudinal Evaluation of Feline Respiratory Illness

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At baseline (Day 0) and on Days 70, 110, 168, 240, 309, 380, and 505 PI, peripheral blood was collected for complete blood count (CBC) and serum for serology; and on Days 0, 110, 168, 240, 309, 380, and 505 PI radiographic ventrodorsal (VD) and lateral thoracic images were acquired and bronchoalveolar lavage (BAL) performed with 10 mL of lactated Ringers solution under sedation with an intramuscular (IM) dose of medetomidine (Domitor®, Zoetis, NY), butorphanol (Torbugesic®; Zoetis), ketamine (ketamine hydrochloride; Zoetis), and after the procedures an IM dose of atipamezole (Antisedan®; Zoetis) was administered. Cats were monitored daily and physical examination performed weekly.
At the termination of the study (Day 510), cats were humanely euthanized after sedation using pentobarbital sodium and phenytoin sodium solution 1 mL/10 lbs. given intraperitoneally (Euthasol®, Virbac AH). Complete necropsies were conducted with collection of lung, heart, brain, kidney, and liver for histopathology studies. Immediately post mortem a blood sample from the right ventricle was collected for serology. Right caudal lung lobes were fixed perfused with 10% formalin via the bronchi to a pressure of 14 cm H₂O. Pathologists and radiologists were blinded to the treatment groups to which cats were assigned, creating a controlled, blind study format.

Dillon A.R., Blagburn B.L., Tillson M., Brawner W., Welles B., Johnson C., Cattley R., Rynders P, & Barney S. (2017). The progression of heartworm associated respiratory disease (HARD) in SPF cats 18 months after Dirofilaria immitis infection. Parasites & Vectors, 10(Suppl 2), 533.

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Standardized Anesthesia and Pain Management for Canine Orthopedic Surgeries

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All dogs received a standardized anesthesia/pain management protocol. Dogs were premedicated with intravenous injection of either acepromazine (5 μg/kg, Sedaject; Samu Median Co., Korea) and medetomidine (1–2 μg/kg, Domitor; Zoetis, Korea) according to the dog's American Society of Anesthesiologists grade. Induction of anesthesia was achieved with alfaxalone (2 mg/kg intravenously; Alfaxan; Jurox), and anesthesia was maintained with isoflurane (Ifran; Hana Pharm. Co., Korea) in oxygen using a vaporizer set at 1.2%–1.8%.
The same surgeon and assistant performed all operations. A tibial plateau leveling osteotomy (TPLO) or medial patellar luxation repair (MPLR) or tibial tuberosity fixation was performed on the affected stifle, as previously reported [14 (link)15 (link)16 (link)]. The method of surgery was determined by the surgeon's preference and experience. After stifle surgery, all dogs had a Robert Jones bandage (RJB) applied to the limb. The bandage was replaced once at 24 h after surgery and removed after 48 h. All dogs received firocoxib (5 mg/kg, orally every 24 h; Previcox, Boehringer-Ingelheim) and misoprostol (0.5 mg/kg, orally every 24 h; Alsoben, Unimed) for 28 days beginning the morning after the treatment.

Han J.Y., Kim W.H, & Kang B.J. (2021). Hyperbaric gaseous cryotherapy for postoperative rehabilitation enhances functional recovery of canine stifle joint: a report on a short-term study. Journal of Veterinary Science, 22(6), e80.

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