Discovery vct pet ct scanner

Nine patients, 5 males and 4 females aged 71 ± 6 years, all with diagnosed idiopathic pulmonary fibrosis (IPF), underwent ¹⁸F-FDG dynamic PET/CT with the protocol outlined in Table 1 using a GE Discovery VCT PET/CT scanner. All patients were imaged supine immediately post-injection using 209 ± 23 MBq ¹⁸F-FDG. The study was split into three stages (early, mid and late) to relieve patient discomfort during the long acquisition. The duration of the cine-CTs acquired for early and mid-cycle stages was set to the duration of the patient’s complete breathing cycle plus one extra second. A cine-CT obtains multiple CT acquisitions over time for each patient slice building up a 4D CT dataset [24 (link)]. The final stage of the study was a normal clinical static PET with a shallow breathing ‘snap shot’ CT study.
The patient data used in this study were the baseline scans (i.e. prior to patient dosing) obtained from a dose escalation study (NCT01725139) of omnipalisib (GSK2126458) in patients with IPF that included FDG-PET as one of the pharmacodynamics endpoints. Institutional Review Board permission, the UK Medicines and Healthcare Products Regulatory Agency (MHRA) approval and informed patient consent were obtained for the study.

PET/CT data were obtained by a Discovery VCT PET/CT scanner (GE Healthcare). All patients received an injection of 3 MBq NaF per kg body weight after having fasted for 6 h. Image acquisition started approximately 60 min after tracer injection. A diagnostic contrast-enhanced CT scan (64-slice helical, 120 kV, “smart mA” maximum 400 mA) was obtained from the base of the skull to the mid-thigh. The CT slice thickness used in the analysis was 3.75 mm. A PET scan with an acquisition time of 2.5 min per bed position was obtained from the same region.
Whole-body planar bone scans with anterior and posterior views were acquired using a dual head ɣ camera (Skylight or PRISM XP2000, Philips Medical, Surrey) with LEHR collimator, energy window 140 keV ±20%, matrix 256×1024, and scan speed 14 cm/min. All patients received 600 MBq Tc-99m HDP and imaging acquisition was performed 3 h postinjection.