Genesis signa

Manufactured by GE Healthcare

Sourced in Germany, United States

The Genesis Signa is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It is designed to capture high-quality images of the body's internal structures, providing healthcare professionals with valuable diagnostic information.

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Lab products found in correlation

Signa excite, by GE Healthcare (3 mentions) Discovery mr750, by GE Healthcare (2 mentions) Magnetom skyra, by Siemens (2 mentions) Achieva, by Philips (2 mentions) Intera, by Philips (2 mentions) Espree, by Siemens (2 mentions) Discovery mr450, by GE Healthcare (1 mentions) Signa hdxt, by GE Healthcare (1 mentions) Gadovist, by Bayer (1 mentions) Ingenia cx, by Philips (1 mentions) Magnetom avanto, by Siemens (1 mentions) Tim trio, by Siemens (1 mentions) Magnetom verio, by Philips (1 mentions) Magnetom trio tim system, by Siemens (1 mentions) Ingenia, by GE Healthcare (1 mentions) Discovery mr750, by Siemens (1 mentions) Gyroscan nt, by Philips (1 mentions) Optima mr450w, by GE Healthcare (1 mentions) Mr750w, by GE Healthcare (1 mentions) Signa architect, by GE Healthcare (1 mentions)

15 protocols using genesis signa

Cardiac MRI Imaging Protocol

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CMR imaging was performed on clinical 1.5-T (n = 46) and 3-T (n = 16) MRI systems (Signa Excite: n = 27; Discovery MR750: n = 16; Discovery MR450: n = 12; Signa HDxt: n = 6; Signa Genesis: n = 1; all GE Healthcare, Milwaukee, WI, USA). Functional imaging was performed with the use of a segmented balanced steady-state free precession cine imaging with breath-holding. Cine images were performed with slice thickness 8 mm and interslice gap 2 mm. Late gadolinium enhancement (LGE) images were acquired 10-15 minutes after the administration of 0.1-0.2 mmol/kg of gadolinium-based contrast agent with the use of an inversion-recovery gradient-echo pulse sequence with continued adjustment of inversion time to null normal myocardium. Cine and LGE images were acquired in standard long-axis views and short-axis orientations covering the entire LV.

van Waning J.I., Caliskan K., Chelu R.G., van der Velde N., Pezzato A., Michels M., van Slegtenhorst M.A., Boersma E., Nieman K., Majoor-Krakauer D, & Hirsch A. (2020). Diagnostic Cardiovascular Magnetic Resonance Imaging Criteria in Noncompaction Cardiomyopathy and the Yield of Genetic Testing. The Canadian journal of cardiology, 37(3), 433-442.

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Comprehensive Knee MRI Evaluation Protocol

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Knee MRI studies were obtained using three various MR scanners (Signa Genesis or Signa Excite; GE Medical Systems, Milwaukee, WI, USA for 1 case, MAGNETOM Skyra; Siemens Healthcare, Erlangen, Germany TIM TX TrueShape; Siemens Healthcare for 11 cases, Achieva; Philips Medical Systems, Best, the Netherlands for 3 cases) with a dedicated 15-channel knee coil in a neutral position of the knee. For conventional 2D MR imaging, fat-suppressed axial proton-density fast spin-echo (FSE), fat-suppressed coronal proton-density FSE, sagittal proton-density FSE, coronal T1-weighted FSE, and fat-suppressed sagittal T2-weighted FSE images were obtained. After intravenous administration of contrast medium (Gadovist; Bayer Schering Pharma AG, Berlin, Germany) at a dose of 7.5 mL, axial and coronal fat-suppressed spin-echo T1-weighted images were obtained. Details of the MR protocol are described in Table 1.

Comparison of MR Findings between Patients with Septic Arthritis and Acute Gouty Arthritis of the Knee. (2022). Journal of the Korean Society of Radiology, 83(5), 1071-1080.

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Multimodal MRI Imaging Protocol

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MRI was performed with various machines, including 1.5T (Magnetom Avanto, Siemens Healthineers, Erlangen, Germany; Genesis Signa, GE Healthcare, Milwaukee, WI, USA; Intera, Philips Healthcare, Best, Netherlands) and 3T scanners (Ingenia CX, Philips Healthcare; Achieva, Philips Healthcare). The parameters for the DWI sequences included the following: repetition time, 3000–8000 ms; echo time, 56–103 ms; flip angle, 90°; matrix, 256 × 256–512 × 512; FOV, 220 × 220–250 × 250 mm; number of excitations, 1–6; number of slices, 20–45; and slice thickness, 3–5 mm; b-value, 1000 s/mm².

Woo I., Lee A., Jung S.C., Lee H., Kim N., Cho S.J., Kim D., Lee J., Sunwoo L, & Kang D.W. (2019). Fully Automatic Segmentation of Acute Ischemic Lesions on Diffusion-Weighted Imaging Using Convolutional Neural Networks: Comparison with Conventional Algorithms. Korean Journal of Radiology, 20(8), 1275-1284.

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TMJ MRI Imaging Protocol

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All patients underwent MRI examinations of the bilateral TMJ. The MR images were obtained using a 3.0T MRI system (Genesis Signa; GE Medical System) with a 6 cm × 8 cm diameter surface coil. All scans involved sagittal oblique sections of ≤ 3 mm, a 15 cm field of view, and a 256 × 224 matrix. T2-weighted images (T2WIs) were obtained using a 2,650/82 TR/TE sequence; T1-weighted images (T1WIs) were obtained using a 650/14 TR/TE sequence; and proton density images were obtained using a 2,650/82 TR/TE sequence. Spin-echo sagittal MR images were obtained using an axial localizer.

Lee Y.H., Won J.H., Kim S., Auh Q.S, & Noh Y.K. (2022). Advantages of deep learning with convolutional neural network in detecting disc displacement of the temporomandibular joint in magnetic resonance imaging. Scientific Reports, 12, 11352.

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MRI Acquisition Protocol for T1 and T2 Imaging

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All MR images were acquired using a 1.5-T MRI system (Genesis Signa; GE Healthcare) with a 12-channel head coil. The MRI parameters for T1WI were as follows: 3D-IR-SPGR; sagittal plane; TR, 8 ms; TE, 3 ms; flip angle, 15°; FOV, 220 × 220 mm; matrix, 256 × 256; voxel size, 0.86 × 0.86 × 1.5 mm; number of slices, 248; and number of averages, 1. Meanwhile, those for T2WI were as follows: 2D-TSE; TR, 4000 ms; TE, 106 ms; FOV, 220 × 220 mm; matrix, 320 × 256; voxel size, 0.43 × 0.43 × 6 mm; interslice gap, 1.5 mm; number of slices 24; and number of averages 1.

Wang J., Sugiyama A., Yokota H., Hirano S., Cooper G., Mukai H., Ohira K., Koide K., Ito S., Finke C., Brandt A.U., Paul F, & Kuwabara S. (2022). Diagnostic efficacy of the magnetic resonance T1w/T2w ratio for the middle cerebellar peduncle in multiple system atrophy and spinocerebellar ataxia: A preliminary study. PLoS ONE, 17(4), e0267024.

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Detailed MRI Protocol for TMJ Assessment

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All patients underwent MRI examination of the bilateral TMJ; images were taken using a 1.5 T MRI system (Genesis Signa; GE Medical System), with a 6-cm × 8-cm diameter surface coil. All scans involved sagittal oblique sections of 3 mm or less, a 15-cm field of view, and a 256 × 224 matrix. T2-weighted images (T2WIs) were obtained using a 2,650/82 TR/TE sequence; T1-weighted images (T1WIs) were obtained using a 650/14 TR/TE sequence; and proton density images were obtained using a 2,650/82 TR/TE sequence. Spin-echo sagittal MR images were planned on the axial localizer images.
TMJs were imaged in the sagittal and coronal planes to determine the presence of internal derangement, effusion, disk deformity, condylar degeneration, or LPM alteration. Disk position in the oblique sagittal plane was determined in the closed- and open-mouth positions. The images were interpreted by two independent observers; both were experts in head and neck MRI.

Lee Y.H., Lee K.M., Auh Q.S, & Hong J.P. (2018). Magnetic Resonance Imaging-Based Prediction of the Relationship between Whiplash Injury and Temporomandibular Disorders. Frontiers in Neurology, 8, 725.

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Standardized MRI Imaging Protocol for Cervical Spine

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All MRI examinations were acquired on the same 1.5 Tesla GE Genesis Signa scanner (GE Healthcare, Milwaukee, WI). We assessed sagittal T2 fast spin echo (FSE), sagittal T1, and axial T2 FSE sequences performed as part of our routine imaging protocol, with these sequences not significantly changing in technique over the study interval. Additional sequences performed as part of our trauma imaging protocol were not evaluated. Sequences were performed with the following parameters (presented as mean values±standard deviation from 10 randomly selected exams): for axial T2 FSE through the entire cervical spine, TR=3798ms±586ms, TE=102ms±6ms, slice thickness=3mm, echo train length (ETL)=17±3.4, in plane field of view (FOV)=160×160mm with a 512×512 matrix for nominal in-plane resolution of 0.31-mm²; for sagittal T2 FSE, TR=3585ms±563ms, TE=105ms±5ms, slice thickness=3mm, ETL=17.1±3, in plane FOV=200×200 mm; and for sagittal T1 TR=528±103, TE=16ms±1.3ms, slice thickness=3mm, ETL=2.6ms±0.8ms, and in plane FOV=200×200mm with a with a 512×512 matrix for nominal in-plane resolution of 0.39-mm².

Haefeli J., Mabray M.C., Whetstone W.D., Dhall S.S., Pan J.Z., Upadhyayula P., Manley G.T., Bresnahan J.C., Beattie M.S., Ferguson A.R, & Talbott J.F. (2017). Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury. AJNR: American Journal of Neuroradiology, 38(3), 648-655.

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Multi-Modal MRI Protocol for Brain Imaging

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MRI was performed using several clinical systems, including 1.5T (Genesis Signa and Signa Excite, GE Healthcare, Milwaukee, Wisconsin; Magnetom Essenza, Espree, and Avanto, Siemens, Erlangen, Germany) and 3T systems (TrioTim, Symphony, Skyra, and Verio, Siemens, Erlangen, Germany). The imaging protocol varied, depending on the scanner and year of study. All protocols included fluid attenuated inversion recovery (FLAIR), gradient echo/susceptibility weighted (GRE/SWI), and pre- and postcontrast T1-weighted (T1W) sequences.

Lazor J.W., Stein J.M., Schmitt J.E., Davis K.A, & Nabavizadeh S.A. (2020). Epilepsy Lesion Localization is not Predicted by Developmental Venous Anomaly Location or its FDG-PET Metabolic Activity. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 30(4), 544-550.

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Standardization of Multimodal Brain MRI

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All enrolled subjects underwent MRI of the head prior to surgery, including several different acquisition protocols [axial T1WI and T2WI, axial, coronal, and sagittal contrast-enhanced T1WI (CE-T1WI)]. The contrast agent, dimeglumine gadopentetate, was injected at a dose of.2 ml/kg, following pre-contrast T1 scanning. MRI images were obtained from four different MRI scanners with 3 T (GE Discovery MR 750, n = 59; Siemens MAGNETOM Trio TimSystem, n = 43; Siemens MAGNETOM Verio, n = 22; Philips Ingenia, n = 9), and a 1.5 T scanner (GE Medical System Genesis Signa, n = 35). Supplementary Material 2 shows the type of the contrast medium and the parameters used for axial CE-T1WI for five MRI modalities.
Whole tumors, based on preoperative axial CE-T1WI images, were identified as the region of interest (ROI). The manual delineation of each ROI was conducted by a neuroradiologist with 5 years of experience, using 3D-Slicer software (version 4.10.2 r28257, National Institutes of Health). Prior to segmentation, we applied three steps to standardize different MRI images: N4ITK bias correction, resampling with resampled voxel sizes of 1, 1, and 1, and Laplacian of Gaussian (LOG) with LOG kernel sizes being 1.5, 2, and 2.5 by 3D-Slicer.

Zhang Y., Luo Y., Kong X., Wan T., Long Y, & Ma J. (2022). A Preoperative MRI-Based Radiomics-Clinicopathological Classifier to Predict the Recurrence of Pituitary Macroadenoma Within 5 Years. Frontiers in Neurology, 12, 780628.

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Longitudinal Brain Imaging Protocol

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Each participant received two scans on a scanner of the same manufacturer and model at both occasions to minimize artifact differences in longitudinal registrations. The mean interval between successive scans was 3.8 years. All images were acquired at the Imaging Research Center of the University of California, Davis. The scanners had field strengths of 1.5T and 3T. The 1.5T GE Genesis Signa had the following parameters: Scan type FSPGR, flip angle 15°, TR 8.9 ms, field of view 25 cm, slice thickness 1.5 mm. The 3T Siemens Trio had the following parameters: Scan type MPRAGE, flip angle 7°, TR 2500 ms, field of view 25cm, slice thickness 1.5 mm.

Fletcher E., Villeneuve S., Maillard P., Harvey D., Reed B., Jagust W, & DeCarli C. (2016). β-amyloid, hippocampal atrophy and their relation to longitudinal brain change in cognitively normal individuals. Neurobiology of aging, 40, 173-180.

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