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Norepinephrine bitartrate salt monohydrate

Manufactured by Merck Group
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Norepinephrine bitartrate salt monohydrate is a chemical compound used in various laboratory applications. It is the salt form of the neurotransmitter norepinephrine, also known as noradrenaline. This product is typically used as a reference standard or in the development and testing of analytical methods.

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Lab products found in correlation

Sodium phosphate dibasic, by Merck Group (1 mentions) Epinephrine bitartrate salt, by Merck Group (1 mentions) Potassium ferricyanide 3 k3 fe cn 6, by Merck Group (1 mentions) Ammonium chloride nh4cl, by Merck Group (1 mentions) Gold 3 chloride solution, by Merck Group (1 mentions) Dopamine hydrochloride, by Merck Group (1 mentions) Isoproterenol hydrochloride, by Bio-Techne (1 mentions) Prazosin hydrochloride, by Merck Group (1 mentions) Picrotoxin, by Bio-Techne (1 mentions) Methoxamine hydrochloride, by Merck Group (1 mentions) Tetrodotoxin citrate, by Bio-Techne (1 mentions)

Close spelling variants of this product

Norepinephrine (248 citations) Norepinephrine bitartrate (14 citations) L-(−)-norepinephrine (+)-bitartrate salt monohydrate (11 citations) (±)-norepinephrine (+)-bitartrate salt (7 citations) L-(−)-norepinephrine (+)-bitartrate salt monohydrate (NE, (4 citations) Norepinephrine bitartrate salt monohydrate (NE; (4 citations)

4 protocols using norepinephrine bitartrate salt monohydrate

1

Electrochemical Characterization of Neurotransmitters

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Dopamine hydrochloride (DA), epinephrine bitartrate salt (EP), norepinephrine bitartrate salt monohydrate (NEP), sodium monobasic phosphate (Na2HPO4), sodium dibasic phosphate (NaH2PO4), potassium chloride (KCl), potassium ferricyanide (III) (K3[Fe(CN)6]), potassium ferrocyanide (II) (K4[Fe(CN)6]), gold (III) chloride solution, and ammonium chloride (NH4Cl) were purchased from Sigma-Aldrich (Buchs, Switzerland). All solutions were prepared in phosphate buffer 0.1 M, KCl 0.1 M, pH 7.4 (PBS). High-purity deionized water (resistance: 18.2 MΩ cm at 25 °C; TOC < 10 µg L−1) obtained from Millipore (Molsheim, France) has been used throughout experiments.
Tortolini C., Cass A.E., Pofi R., Lenzi A, & Antiochia R. (2022). Microneedle-based nanoporous gold electrochemical sensor for real-time catecholamine detection. Mikrochimica Acta, 189(5), 180.
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2

Pharmacological Evaluation of Neurotransmitter Modulators

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Isoproterenol hydrochloride, tetrodotoxin citrate, and picrotoxin were purchased from Tocris Bioscience. Norepinephrine bitartrate salt monohydrate, methoxamine hydrochloride, and prazosin hydrochloride were purchased from Sigma-Aldrich. All experimental drugs were bath applied at their final concentrations as noted in the text. Dimethylsulfoxide (DMSO) was the solvent used for stock solution of picrotoxin where the maximum final concentration of DMSO in ACSF was 0.02% by volume. All other drugs, with the exception of prazosin, were easily dissolved in water. Prazosin was dissolved in water with vigorous heating and stirring.
Williams M.A., Li C., Kash T.L., Matthews R.T, & Winder D.G. (2014). Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner. Neuropharmacology, 86, 116-124.
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3

Adrb2 Agonist Effects on MIN6 Cells

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MIN6 cells less than passage 30 were plated in 6-well dishes and allowed to grow to ~90% confluency. Cells were then treated with either control (water or methanol) or 10 µM Adrb2 agonist for 16 hr before being collected for qPCR. Norepinephrine (L-(−)-Norepinephrine (+)-bitartrate salt monohydrate, Sigma cat# A9512) and epinephrine (±)-Epinephrine hydrochloride, Sigma cat# E4642) were dissolved in water; salbutamol (Sigma cat# S8260) was dissolved in methanol.
Ceasrine A.M., Lin E.E., Lumelsky D.N., Iyer R, & Kuruvilla R. (2018). Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. eLife, 7, e39689.
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4

Pharmacological Evaluation of Vasoactive Agents

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The following drugs were used: yohimbine hydrochloride (VWR), atropine sulfate monohydrate (VWR), and (-)norepinephrine (+)-bitartrate salt monohydrate (Sigma).
Drugs were dissolved in dH2O into stock solutions and diluted in KHB to working concentrations on the day of experiment. Control experiments were performed in the presence of drug-free solvents, using identical conditions applied for drug application.
Cao L.L., Marshall J.M., Fabritz L, & Brain K.L. (2021). Resting cardiac sympathetic firing frequencies suppress terminal norepinephrine transporter uptake. Autonomic neuroscience : basic & clinical, 232.
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