Igf1fl fl

Manufactured by Jackson ImmunoResearch

Igf1fl/fl is a genetic construct that contains loxP sites flanking the insulin-like growth factor 1 (Igf1) gene. This allows for the conditional deletion of the Igf1 gene in cells or tissues of interest when expressed with Cre recombinase.

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Lab products found in correlation

Cd11ccre gfp, by Jackson ImmunoResearch (1 mentions) Igf1rfl fl, by Jackson ImmunoResearch (1 mentions) C57bl 6, by Jackson ImmunoResearch (1 mentions)

2 protocols using igf1fl fl

Murine Models for Neuroinflammation Studies

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C57BL/6j bom female mice aged 7–8 weeks were obtained from Taconic Europe A/S; CX3CR1^GFP/GFP and CCR2^RFP/RFP, CD11c^Cre‐GFP (Stranges et al, 2007) and Igf1^fl/fl were obtained from The Jackson Laboratory and maintained as a breeding colony (CX3CR1^GFP/GFP and CCR2^RFP/RFP were crossed with B6 mice to obtain heterozygotes) in the Biomedical Laboratory, University of Southern Denmark (Odense). All experiments performed in Denmark were approved by the Danish Animal Experiments Inspectorate (approval number 2014‐15‐0201‐00369). CX3CR1^CreER, CD11c^Cre, DTA, and iDTR mice were housed in specific pathogen‐free conditions and used in accordance with the guidelines of the Central Animal Facility Institution (ZVTE, University of Mainz). Neonatal mice (p2‐p21) used for experiments were of mixed sex.

Wlodarczyk A., Holtman I.R., Krueger M., Yogev N., Bruttger J., Khorooshi R., Benmamar‐Badel A., de Boer‐Bergsma J.J., Martin N.A., Karram K., Kramer I., Boddeke E.W., Waisman A., Eggen B.J, & Owens T. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. The EMBO Journal, 36(22), 3292-3308.

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Organotypic Mouse Brain Imaging

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All experimental procedures were approved and carried out in accordance with the regulations of the Max Planck Florida Institute for Neuroscience Animal Care and Use Committee in accordance with guidelines by the U.S. National Institutes of Health. P4 to P8 mouse pups from both sexes were used for organotypic slices for imaging studies. C57BL/6, Igf1r^fl/fl (#012251), Igf1^fl/fl (#016831), and Igf2^fl/fl (#032493) mice were from The Jackson Laboratory.

Tu X., Jain A., Parra Bueno P., Decker H., Liu X, & Yasuda R. (2023). Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors. Science Advances, 9(31), eadg0666.

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