Resazurin, Roswell Park Memorial Institute medium (RPMI 1640) without phenol red, and Hanks’ Balanced Salt Solution (HBSS), were purchased from Sigma-Aldrich. Sytox Green® and H2CDFDA (2 ‘, 7′-dichlorodihydrofluorescein diacetate) were purchased from Molecular Probes ® (Invitrogen ™). Fetal Bovine Serum (FBS) was obtained from Gibco and gentamicin sulfate from Hipolabor Pharmaceuticals. Benznidazole (BZ) and sertraline (SERT) were purchased from Sigma-Aldrich. All other reagents not mentioned were purchased from Sigma-Aldrich.
Benznidazole bz
Manufactured by Merck Group
Benznidazole (BZ) is a pharmaceutical compound primarily used as an antiparasitic agent. It functions as an inhibitor of the enzyme trypanothione reductase, which is essential for the survival of certain parasitic protozoa, such as Trypanosoma cruzi, the causative agent of Chagas disease. Benznidazole is formulated as a tablet for oral administration.
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2 protocols using benznidazole bz
1
Cytotoxicity Assessment of Compounds
2
Benznidazole Treatment in Chagas Mice
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Both infected and non-infected mice were injected intraperitoneally (IP) with 200 µl Benznidazole (Bz, Sigma) (100 mg per Kg body weight) diluted in 50% DMSO in PBS, for 20 consecutive days [13] (link). After the 20 day treatment, mice were allowed to recover for 20 days and then bled and euthanized for collecting heart and skeletal muscle samples. Data presented are from one experiment, representative of three independent experiments, performed for each of the two drug treatment models.
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