Sr1001

Manufactured by Merck Group

Sourced in United States

SR1001 is a versatile laboratory equipment designed for general research and analysis applications. It functions as a compact, benchtop unit capable of performing various tasks within a controlled environment. The core function of SR1001 is to facilitate controlled and consistent experimental conditions for a range of laboratory procedures.

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Lab products found in correlation

Digoxin, by Merck Group (1 mentions) Mc903, by Merck Group (1 mentions) Ionomycin, by Merck Group (1 mentions) Melatonin, by Merck Group (1 mentions) Sr 1078, by Merck Group (1 mentions) Aa 861, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)

3 protocols using sr1001

In vivo treatment of lesions

Cited 1 time

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Digoxin (Carbosynth) was diluted in PBS and SR1001 (Sigma-Aldrich) was dissolved in 100% DMSO before being diluted in PBS as previously described [37 (link)]. The final concentration of DMSO was 1.5%, which was used in the preparation of the vehicle control. At the onset of visibly swollen lesions (~2 weeks post inoculation), mice were injected intra-peritoneally every second day with 20 mg/kg (1250 μM) SR1001, or 40 μg/mouse of Digoxin, or vehicle control. Treatment continued for 3 weeks in wild type C57BL/6 mice (until week 5 of infection) and for 5–6 weeks in IFN-γ^-/- and IFN-γ^-/- IL-17A^-/- mice (until mice were humanely euthanized).

Hartley M.A., Bourreau E., Rossi M., Castiglioni P., Eren R.O., Prevel F., Couppié P., Hickerson S.M., Launois P., Beverley S.M., Ronet C, & Fasel N. (2016). Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A. PLoS Pathogens, 12(9), e1005852.

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Investigating Cellular Signaling Pathways

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SR1001, MC903 (calcipotriol hydrate), TPA, and ionomycin were purchased from Sigma (Saint Louis, MO).

Dai J., Choo M.K., Park J.M, & Fisher D.E. (2017). Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis. The Journal of investigative dermatology, 137(12), 2523-2531.

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Activation of HSC by Melatonin and Analogs

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Melatonin (Sigma-Aldrich), SR1078 (Merck Millipore, Billerica, MA, USA), SR1001 (Sigma-Aldrich), and AA861 (Sigma-Aldrich) were dissolved in DMSO (Merck) and diluted with medium for final concentrations. Treatment concentrations were 10 lM Melatonin, 10 lM SR1078, 10 lM SR1001, and 10 lM AA861, unless stated otherwise. Isolated HSC were treated 4 hr after plating. Every day medium was changed and supplied with fresh Melatonin, SR1078, SR1001, AA861, or DMSO as control group. Activated HSC were trypsinized and recultured for 3 days. Treatment was started 4 hr after plating.

Shajari S., Laliena A., Heegsma J., Tuñón M.J., Moshage H, & Faber K.N. (2015). Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase. Journal of pineal research, 59(3).

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