Gamma knife unit

Manufactured by Elekta

The Gamma Knife unit is a highly focused radiation therapy device designed for the treatment of intracranial lesions. It utilizes multiple beams of gamma radiation to precisely target and destroy targeted areas within the brain while minimizing exposure to surrounding healthy tissue.

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Close spelling variants of this product

Gamma Knife (18 citations) Leksell Gamma Knife Unit (7 citations) Leksell Gamma Knife Perfexion Unit (4 citations) Gamma Knife Icon unit (2 citations)

2 protocols using gamma knife unit

Single-Fraction Stereotactic Radiosurgery for Brain Tumors

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All patients were treated with single-fraction SRS using a Gamma Knife unit (Elekta Medical Systems, Stockholm, Sweden) at Washington University in St. Louis/Siteman Cancer Center. For treatment planning, both a high-resolution contrast-enhanced MRI as well as a non-contrast-enhanced head computed tomography (CT) scan were obtained, and target delineation and treatment planning were completed by a team of radiation oncologist, neurosurgeon, and medical physicist. Prescription doses were based on Radiation Therapy Oncology Group (RTOG) 90–05, and the doses were generally 20–21 Gy for tumors <2 cm in size, 17–18 Gy for tumors 2–3 cm in size, and 15–16 Gy for tumors >3 cm in size. The prescription dose was selected so that the 50% isodose line would cover the gross tumor volume (GTV). After SRS, patients were followed by both radiation oncology and neurosurgery with standard of care serial brain magnetic resonance imaging (MRI) every three months.

Huang J., Milchenko M., Rao Y.J., LaMontagne P., Abraham C., Robinson C.G., Huang Y., Shimony J.S., Rich K.M, & Benzinger T. (2020). A feasibility study to evaluate early treatment response of brain metastases one week after stereotactic radiosurgery using perfusion weighted imaging. PLoS ONE, 15(11), e0241835.

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Gamma Knife Radiosurgery for AVM

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Radiosurgery was performed with a Leksell Gamma Knife Unit (Elekta, Norcross, Georgia). Under monitored anesthesia for adults and general anesthetic for pediatric patients, a Leksell G-frame was affixed to the patient's head with 4 pins. The treatment target (residual nidus) was defined by 3D stereotactic MR imaging and DSA. Using a combination of DSA and MRI, the nidus was delineated and treated with radiosurgery. The embolized nidus was usually not included in the radiation targeting. On the contrary, the origin of the draining veins was usually included in the radiation targeting. The mean nidus volume was 9.95 cm 3 (range 0.59-57.8 cm 3 ) before GKS, the median margin dose (dose to the edge of the AVM nidus) was 16.3 Gy (range 13-21 Gy), the median central dose was 32.9 Gy (range 26-40 Gy). A total of 13 patients

Huo X., Li Y., Wu Z., Jiang Y., Yang H, & Zhao Y. (2015). Combined treatment of brain AVMs by Onyx embolization and gamma knife radiosurgery decreased hemorrhage risk despite low obliteration rate. Turkish neurosurgery, 25(1).

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