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Myostar catheter

Manufactured by Johnson & Johnson
Sourced in United States

The MyoStar catheter is a medical device used for cardiac procedures. It is designed to measure and monitor various physiological parameters within the heart.

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3 protocols using myostar catheter

1

Electroanatomical Mapping for Stem Cell Therapy

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Electroanatomical mapping was performed using the Biosense NOGA system (Bio-sense-Webster, Diamond Bar, CA), which allows point-by-point analysis of left ventricular viability and local contractility. Using this technique, three-dimensional maps of color-coded myocardial viability (unipolar voltage [UV]) and regional myocardial contraction (local linear shortening [LLS]) and their corresponding 9-segment bull’s-eye maps, consisting of greater than or equal to 150 sampling points were generated for each patient before stem cell transplantation. In accordance with previous studies in NICM,16 (link) segments with electromechanical mismatch (EMM) were defined as areas with average UV greater than or equal to 8.27 mV and average LLS less than 6%, scarred myocardium was defined as areas with UV less than 8.27 mV and LLS less than 6%, and normal myocardium was defined as areas with UV greater than or equal to 8.27 mV and LLS greater than or equal to 6%. After completion of electroanatomical mapping, cells were injected in EMM target zones using the Myo-star catheter (Biosense-Webster) applying pre-specified criteria of UV greater than or equal to 8.27 mV and LLS less than 6%. Each patient received 20 injections of stem cell suspension (0.3 mL each).
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2

Cardiac Electromechanical Mapping for Targeted Cell Delivery

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During cell preparation, biplane left ventricular angiography was performed. Based on ventricular size, the mapping catheter curve (D or F) was selected. Via femoral artery access and a retrograde aortic approach, the catheter was inserted into the left ventricle. A non-fluoroscopic electromechanical map of the left ventricle was constructed using the NOGA system (NOGAStar catheter, Biosense-Webster, Waterloo, Belgium) [19 (link)]. The electromechanical map was used to guide the injection catheter with a 27-gauge retractable needle (MyoStar catheter Biosense-Webster) to the target region, which is the area of stress-inducible ischaemia on SPECT for the patients with ischaemia [19 (link)], and to the peri-infarction zone for patients without ischaemia [20 (link)]. Subsequently, 8–12 injections of approximately 0.2–0.3 ml each were delivered.
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3

Intramyocardial Cell Delivery for Hibernating Myocardium

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Patients underwent electromechanical mapping and the intramyocardial cell/placebo application procedure with the NOGA-XP 3D system (Biosense Webster, Johnson & Johnson, Diamond Bar, CA, USA). During the procedure, approximately 200–250 mapping points were collected in order to obtain a precise electromechanical map of the left ventricle. Target regions of the myocardium with impaired mechanical (LLS (reflecting regional wall motion) < 6%) but maintained electrical activity of ≥ 6.0 mV UV were defined as a viable hibernated myocardium. Thereafter, a median of 10 intramyocardial CD133+ cells (dosing ranges 2.8 × 106–5.3 × 106)/placebo injections were performed using a MyoStar catheter (Biosense Webster, Johnson & Johnson, Diamond Bar, CA, USA).
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