Oxycodone

Manufactured by Cerilliant

Sourced in United States

Oxycodone is a synthetic opioid analgesic that is used in the laboratory setting for research and development purposes. It is a pure chemical substance used to study pain management, drug interactions, and other pharmaceutical applications. The core function of Oxycodone is to serve as a reference standard or analytical tool for various laboratory experiments and analyses.

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Lab products found in correlation

5 protocols using oxycodone

Quantification of Opioids and Cannabinoids in Wastewater

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Morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, Δ⁹-tetrahydrocannabinol (THC) and its metabolites 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) and THCCOOH-glucuronide were purchased from Cerilliant (Round Rock, TX, USA). The deuterated analogs THC-d₃, THCCOOH-d₃, THCCOOH-glucuronide-d₃, Morphine-d₃, oxycodone-d₆, hydrocodone-d₆, oxymorphone-d₃ and hydromorphone-d₆ were also purchased from Cerilliant. Strata XC 33 µm polymeric strong cation exchange cartridges of 3 mL/60 mg for calibrators and 6 mL/200 mg for quality control (QC) and authentic wastewater samples were purchased from Phenomenex (Torrance, CA, USA). Ultra-high performance liquid chromatography (UHPLC) grade methanol, dichloromethane and ammonium hydroxide were purchased from Pharmco-Aaper (Brookfield, CT). Isopropanol, liquid chromatography mass spectrometry grade acetonitrile, and Whatman glass microfiber filters (outside diameter 4.7 cm, particle retention 1.6 μm, and thickness 0.26 mm) were from Thermo Fisher Scientific (Waltham, MA, USA).

Jacox A., Wetzel J., Cheng S.Y, & Concheiro M. (2017). Quantitative analysis of opioids and cannabinoids in wastewater samples. Forensic sciences research, 2(1), 18-25.

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Analytical Standards for Opioid Detection

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Carfentanil, cocaine, fentanyl, heroin, oxycodone, and remifentanil were purchased as analytical standards (100 μg/mL diluted in methanol) from Cerilliant Corporation (Round Rock, TX). Acetyl fentanyl, butyryl fentanyl, crotonyl fentanyl, cyclopropyl fentanyl, p-fluoroisobutyryl fentanyl (FIBF), 2-furanyl fentanyl, β-hydroxythiol fentanyl, methoxy fentanyl, methyl fentanyl, norfentanyl, and U-47700 were purchased as analytical standards (100 μg/mL diluted in methanol) from Cayman Chemical (Ann Arbor, MI). A complete list of test compounds used in this study is shown in Table 1.

Angelini D.J., Biggs T.D., Maughan M.N., Feasel M.G., Sisco E, & Sekowski J.W. (2019). Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl. Forensic science international, 300, 75-81.

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Certified Reference Standards for Drugs

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Certified reference standards of 6-monoacetylmorphine, alprazolam, amphetamine, buprenorphine, benzoylecgonine, carisoprodol, chlordiazepoxide, clonazepam, cocaine, codeine, cotinine, dihydrocodeine, diazepam, EDDP, fentanyl, flurazepam, hydrocodone, hydromorphone, lorazepam, MDA, MDEA, MDMA, methamphetamine, meperidine, morphine, methylphenidate, methadone, naloxone, norbuprenorphine, nicotine, nordiazepam, norfentanyl, noroxycodone, alpha-hydroxyalprazolam, oxazepam, oxycodone, oxymorphone, tapentadol, temazepam, ll-nor-9-Carboxy-Δ9-THC, and cis-tramadol were purchased, each at a concentration of 1 mg/mL, from Cerilliant Corporation (Round Rock, TX). Isotopically labeled internal standards (IS) morphine-D3, codeine- D6, hydrocodone-D3, 6-monoacetylmorphine-D6, hydromorphone-D6, oxymorphone-D3, noroxycodone-D3, and naloxone-D5 were purchased, each at a concentration of 100 μg/mL, from Cerilliant Corporation (Round Rock, TX). Drug-free urine was obtained from Bio-Rad Laboratories (Irvine, CA). High-performance liquid chromatography (HPLC) grade water, methanol, and formic acid were purchased from Fisher Scientific (Pittsburgh, PA) and ammonium formate was purchased from Sigma Aldrich (St. Louis, MO).

Pablo A., Breaud A.R, & Clarke W. (2019). Automated Analysis of Dried Urine Spot (DUS) Samples for Toxicology Screening. Clinical biochemistry, 75, 70-77.

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Quantitative Analysis of APAP and Opioids

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APAP-CYS was obtained from Toronto Research Chemicals as trifluoracetic acid salt (TRC; North Rock, CA). APAP was obtained from Sigma (St. Louis, MO). Hydrocodone, oxycodone, Hydrocodone-D₃, oxycodone-D₆, tramadol-¹³C, D₃ were obtained from Cerilliant (Round Rock, TX). Tramadol HCl was obtained from the R.W. Johnson Pharmaceutical Research Institute. LC-MS grade methanol, dichloromethane, and isopropanol were obtained from Honeywell-Burdick & Jackson (Muskegon, MI). ACS grade ammonium hydroxide, potassium phosphate dibasic, potassium hydroxide, trichloroacetic acid, and formic acid were obtained from Fisher Scientific (Fairlawn, NJ). HPLC grade acetic acid was obtained from J.T. Baker (Phillipsburg, NJ). The 0.1 M acetate pH 4 buffer was prepared from acetic acid and potassium hydroxide.
Analyses for APAP, protein-derived APAP-CYS, and selected opioids commonly found in combination with APAP were conducted at the Center for Human Toxicology. All other data (Table 1) were obtained as part of the routine investigation conducted by the Office of the Medical Examiner.

Thomas K.C., Wilkins D.G., Curry S.C., Grey T.C., Andrenyak D.M., McGill L.D, & Rollins D.E. (2016). Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose. Journal of forensic sciences, 61(5), 1301-1306.

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Comprehensive Analytical Reference Standards

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Certified reference materials of amitriptyline, bupropion, citalopram, desipramine, desmethylcitalopram, duloxetine, fluoxetine, imipramine, mirtazapine, nortriptyline, paroxetine, sertraline and trazodone were purchased from LGC Standards (Teddington, London, UK); certified reference materials of clomipramine, desmethylvenlafaxine, doxepin, hydroxybupropion, norfluoxetine, norsertraline, trimipramine, venlafaxine, 7-amino clonazepam, 7-amino flu nitrazepam, alprazolam, bromazepam, clonazepam, diazepam, flu nitrazepam, lorazepam, midazolam, nitrazepam, nordiazepam, oxazepam, temazepam, zolpidem, 6-monoacetyl morphine, N-desmethyltramadol, buprenorphine, codeine, fentanyl, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, tramadol, bupropion-d 9 , citalopram-d 6 , clonazepam-d 4 , codeine-d 3 , diazepam-d 5 , duloxetine-d 3 and morphine-d 3 from Cerilliant (Round Rock, TX, USA); methanol, acetonitrile, ammonium formate and formic acid from Merck (Darmstadt, Germany); ultrapure deionized water was purified by Milli-Q from Millipore (Billerica, MA, USA). All solvents used in the extraction procedure were HPLC grade. Quantisal™ oral fluid collection devices and elution buffer were purchased from Immunalysis (Pomona, CA, USA).

Arantes A.C.F., Cunha K.F.d., Cardoso M.S., Oliveira K.D., & Costa J.L. (2020). Development and validation of quantitative analytical method for 50 drugs of antidepressants, benzodiazepines and opioids in oral fluid samples by liquid chromatography–tandem mass spectrometry. Forensic Toxicology, 39(1), 179-197.

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