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Poly ethylene glycol methyl ether methacrylate pegma

Manufactured by Merck Group
Sourced in United States

Poly(ethylene glycol)methyl ether methacrylate (PEGMA) is a water-soluble, biocompatible polymer used in various laboratory applications. It serves as a versatile building block for the synthesis of polymeric materials. PEGMA exhibits physical and chemical properties that make it suitable for use in a range of research and development activities.

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5 protocols using poly ethylene glycol methyl ether methacrylate pegma

1

Synthesis and Characterization of Polymers

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Water (18.2 MΩ·cm) was deionized with Merck Millipore (Darmstadt, Germany) purification system. 2-(1-Isobutyl)sulfanylthiocarbonylsulfanyl-2-methyl propionic acid was prepared as reported previously34 (link). 2,2′-Azobis[2-(2-imidazolin-2-yl) propane] (VA-061) was purchased from Wako Pure Chemical Industries (Tokyo, Japan). The inhibitors, poly(ethylene glycol)methyl ether methacrylate (PEGMA, Mn = 500 and 2,000 g/mol), and all other reagents were purchased from Sigma-Aldrich (St. Louis, MO) and used without further purification.
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2

Synthesis of Stimuli-Responsive Polymeric Nanocarriers

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Methacrylic acid (MAA, 99%), 2,2′-Azobisisobutyronitrile (AIBN, 98%) and N,N′-methylenebisacrylamide (MBA, 96%) were purchased from Acros. N,N-dimetilaminoethylethacrylate (DMAEMA), Poly(ethyleneglycol)methylethermethacrylate (PEGMA; Mn = 475) and acetonitrile (ACN) were obtained from Sigma-Aldrich., N′-bis(acryloyl)cystamine (BAC, 98%) was purchased from Alfa Aesar. Daunorubicin HCl (DNR) was provided by Pharmacia & Upjohn.
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3

Synthesis of Methacrylate-based Nanocomposites

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For the reagents used in this study, including 2-hydroxyethyl methacrylate (HEMA) and azobisisobutyronitrile (AIBN), the products of Junsei were used, and methacrylic acid (MA), ethylene glycol dimethacrylate (EGDMA), Poly (ethylene glycol) methyl ether methacrylate (PEGMA), and Neodymium (III) oxide nanoparticles were purchased from Sigma-Aldrich (Saint Louis, MO, USA) and used without purification.
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4

Biodegradable Polymer Synthesis and Characterization

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ε-Caprolactone (CL, Acros, 99% purity), 2-ethylhexanoic acid tin(II) salt (Sn(Oct)2; Sigma-Aldrich, St. Louis, MO, USA, purity ≥95%), 4,4′-Azobis(4-cyanovaleric acid) (ACVA; Sigma-Aldrich, purity ≥ 98%), 4-Cyano-4-(phenylcarbonothioylthio)pentanoic acid (CPA; Sigma-Aldrich, purity ≥ 97%), poly(ethylene glycol) methyl ether methacrylate (PEGMA; Sigma-Aldrich, Mn 950 Da), Tween80 (Sigma-Aldrich), Diethyl ether (DEE, Sigma-Aldrich, ≥99%), Deuterated chloroform (CDCl3, Sigma-Aldrich, 99.8%), Ethanol (EtOH, Sigma-Aldrich, 99.8%), acetonitrile (ACN, Sigma-Aldrich, 99.9%), 6-hydroxycaproic acid (HCA, ABCR, Karlsruhe, Germany, 95%) were used as received without further treatments. The cell medium is composed by high glucose DMEM/F12 (Biowest, Nuaillé, France) supplemented with 10% fetal bovine serum (Lonza, Basel, Switzerland). Phosphate-buffered saline solution (PBS) was purchased from Sigma-Aldrich. For gel permeation chromatography (SEC) analysis Tetrahydrofuran (THF, Sigma-Aldrich, purity ≥ 99.7%) was used as eluent.
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5

Synthesis of Functionalized Polymers

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2-Vinylpyridine (97%,
2VP; Sigma-Aldrich,
U.K.) and divinylbenzene (80 mol % 1,4-divinyl content, DVB; Sigma-Aldrich,
U.K.) were passed through a column of activated basic alumina to remove
inhibitors and impurities before use. 2,2′-Azodiisobutyramidine
dihydrochloride (AIBA; 97%) was purchased from Sigma-Aldrich (U.K.)
and used as received. Aliquat 336 surfactant (Thermo Fisher, U.K.)
was used as received. Poly(ethylene glycol) methyl ether methacrylate
(PEGMA, average Mn 2000 g mol–1, Sigma-Aldrich, U.K.) was supplied as a 50 wt % solution in H2O. PCR reagents were used as received. DNA extraction and
purification kits (Qiagen, U.K.) were used as per manufacturer’s
instructions. qPCR reagents (Thermo Fisher, U.K.) and viral extraction
reagents (Invitrogen, U.K.) were used as received.
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