Urb937

Manufactured by Cayman Chemical

Sourced in United States

URB937 is a lab product manufactured by Cayman Chemical. It is a selectively active inhibitor of fatty acid amide hydrolase (FAAH) enzyme.

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Lab products found in correlation

5 protocols using urb937

Pharmacological Modulation of Endocannabinoid System

Cited 2 times

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Paclitaxel (Tecoland Corporation, Edison, NJ, USA) was dissolved in a 1: 1: 18 ratio of cremophor EL: ethanol: saline and injected intraperitoneally (i.p.) in a volume of 6.67 mL/kg. URB597, URB937 and WIN55,212–2 (all from Cayman chemical Company, Ann Arbor, MI) and rimonabant (National Institute on Drug Abuse, Bethesda, MD) were dissolved in a vehicle consisting of 20% DMSO: 8% ethanol: 8% emulphor and 64% saline and administered via intraperitoneal (i.p.) injection in a volume of 5 mL/kg. FAAH inhibitors (URB597, URB937) were administered 2 hours prior to behavioral testing (i.e. when AEA and other fatty acid amides are validated to be elevated but 2-AG levels are unaffected) [8 (link)]. WIN55,212–2 was administered (i.p.) 30 minutes prior to behavioral testing as performed in our previous work [30 (link)].

Slivicki R.A., Xu Z., Mali S.S, & Hohmann A.G. (2019). Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro. Pharmacological research, 142, 267-282.

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Cannabinoid compounds administration

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URB597 (Sigma Aldrich) and URB937 (Cayman Chemical) were dissolved in 18:1:1 normal saline:PEG400:Tween80 (Sigma Aldrich) and administered to mice via intraperitoneal injection at a dosage of 0.1–1mg/kg bodyweight four hours prior to behavioral testing or sacrifice.

Markey L., Hooper A., Melon L.C., Baglot S., Hill M.N., Maguire J, & Kumamoto C.A. (2020). Colonization with the commensal fungus Candida albicans perturbs the gut-brain axis through dysregulation of endocannabinoid signaling. Psychoneuroendocrinology, 121, 104808.

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Synthesis and Characterization of Endocannabinoids

Cited 1 time

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Sobetirome and d₆-sobetirome were synthesized as previously described.^{40 (link), 41 (link)} Anandamide (AEA, #90050), PF-3845 (#13279), and URB-937 (#10674) were purchased from Cayman. Arachidonic acid was purchased from Sigma (#23401). d₁₁-Arachidonic acid was purchased from Avanti (#861810E). Fatty-acid free BSA was from Alfa Aesar (#64682). Solvents were HPLC grade from Fisher.

Meinig J.M., Ferrara S.J., Banerji T., Banerji T., Sanford-Crane H.S., Bourdette D, & Scanlan T.S. (2017). Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy. ACS chemical neuroscience, 8(11), 2468-2476.

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Pharmacological Compounds for Endocannabinoid Research

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GW6471, AM251, URB937, PF3845, AMC-AEA, LEI-401, PEA, d₄-PEA, OEA, d₂-OEA, 2-AG, and d₅-2-AG were purchased from Cayman Chemical (Ann Arbor, MA). NGF was from Gibco (Waltham. MA). AEA and d₄-AEA were from R&D Systems (Minneapolis, MN). Capsaicin was from Sigma-Aldrich (St. Louis, MO), Fura-2AM and PED-A1 were from Thermo Fisher (Waltham, MA) and Cyclosporin A was from TCI (Portland, OR).

Bogdan D.M., Studholme K., DiBua A., Gordon C., Kanjiya M.P., Yu M., Puopolo M, & Kaczocha M. (2022). FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain. Scientific Reports, 12, 9241.

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Dissolution and Dosing of Analgesics

Cited 3 times

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Cisplatin was purchased from Tocris (Ellisville, MO, USA) and dissolved in normal saline (0.9% NaCl). Amitriptyline hydrochloride, gabapentin, and ibuprofen were purchased from Sigma-Aldrich (St. Louis, MO, USA) and dissolved in normal saline (0.9% NaCl). URB937 (3′-carbamoyl-6-hydroxy-[1,1′-biphenyl]-3-yl cyclohexylcarbamate) was purchased from Cayman Chemical (Ann Arbor, MI, USA) and dissolved in dimethylsulfoxide. Doses of amitriptyline, gabapentin, ibuprofen, and URB937 were selected based upon efficacy demonstrated in the previous studies.^{21 (link)–23 (link, link)}

Thompson J.M., Blanton H.L., Pietrzak A., Little W., Sherfey C, & Guindon J. (2019). Front and hind paw differential analgesic effects of amitriptyline, gabapentin, ibuprofen, and URB937 on mechanical and cold sensitivity in cisplatin-induced neuropathy. Molecular Pain, 15, 1744806919874192.

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