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Z vad cho

Manufactured by Merck Group

Z-VAD-cho is a laboratory reagent used as a pan-caspase inhibitor in cell culture and research applications. It functions by inhibiting the activity of caspase enzymes, which play a crucial role in the process of programmed cell death (apoptosis).

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2 protocols using z vad cho

1

Temozolomide and Caspase Inhibitor Assay

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Temozolomide (TMZ), AICAR and caspase inhibitors (z-DEVD-cho and z-VAD-cho) were purchased from Sigma-Aldrich Chemicals (St. Louis, MO). GSK621 was purchased from Selleck (Shanghai, China). All the antibodies utilized in this study were purchased from Cell Signaling Tech (Shanghai, China).
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2

Inhibition of Apoptosis Pathway

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PKC412 was purchased from Shanghai Lan-jun Biotechnology (Shanghai, China). The Bcl-2 inhibitor ABT-737 was obtained from Selleck (Shanghai, China). Caspase inhibitors z-VAD-CHO and z-DEVD-CHO were obtained from Sigma Chemicals (Shanghai, China). All antibodies utilized were obtained from Cell Signaling Tech (Denver, MA).
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