Nitrendipine

Felodipine (Cat. No. F0814; Tokyo Chemical Industry, Tokyo, Japan) and nitrendipine (Cat. No. 17549; Cayman Chemical Company, Ann Arbor, MI, USA) were dissolved in dimethyl sulfoxide (1% DMSO) for in vitro experiments or 5% Tween-20 + 5% PEG300 in saline for in vivo experiments.

Nifedipine, nisoldipine, nitrendipine, nilvadipine, and isradipine were obtained from Tokyo Chemical Industry (Tokyo, Japan) and Wako Pure Chemical Industries (Osaka, Japan). PSB-1115 was purchased from Santa Cruz Biotechnology. Amlodipine besylate (amlodipine), adenosine deaminase (ADA), N6-cyclopentyladenosine (CPA), forskolin, and adenosine were purchased from Sigma (St. Louis, MO). CGS21680, IB-MECA, and EHNA hydrochloride (EHNA) were obtained from Abcam (Cambridge, UK). BAY60-6583 was purchased from Tocris Bioscience (Bristol, UK). The compound library consisting of 1,241 existing medicines was a kind gift from LTT Bio-Pharma Co., Ltd (Tokyo, Japan).