Anisole

Iron (II) stearate (Strem Chemicals, Bischheim, France, 9% Fe), ethanol, acetone, and hexane from Alfa Aesar were used without purification. Octyl ether (Sigma-Aldrich, Saint-Quentin-Fallavier, France, 99%) and oleic acid (90%, Alfa Aesar, Kandel, Germany) were distilled under reduced pressure. The purity of Octyl ether was controlled by gas chromatography. Toluene (Carlo Erba, Val de Reuil, France, 99.9%) and anhydrous THF (Carlo Erba, Val de Reuil, France, 99.9%) were refluxed and distilled over sodium and sodium/benzophenone, respectively. Copper (I) bromide (Sigma-Aldrich, Saint-Quentin-Fallavier, France, 98%), N,N,N′N″,N″-pentamethyldiethylenetriamine (PMDETA, Sigma-Aldrich, Saint-Quentin-Fallavier, France, 99%), ethyl-2-bromoisobutyrate (Alfa Aesar, Kandel, Germany, 98%), and Anisole (Sigma-Aldrich, Saint-Quentin-Fallavier, France, 99%) were used without purification. Styrene (Sigma-Aldrich, Saint-Quentin-Fallavier, France, 99%) was distilled over sodium under reduced pressure. Methyl methacrylate (Acros Organics, Geel, Belgium) was purified by column chromatography on basic aluminum oxide (Sigma-Aldrich, Saint-Quentin-Fallavier, France). 11-Phosphonoundecyl 2-bromo-2-methyl-propionate (M_W = 401.28 g/mol) as an ATRP initiator with a C₁₁ spacer was synthetized in the laboratory, following the experimental method reported by Maliakal et al. [18 (link)].

N,N‐dimethylformamide (DMF, anhydrous, 99.8%), dimethyl sulfoxide (DMSO, anhydrous, ≥99.9%), and anisole (anhydrous, 99.7%) were purchased from Sigma‐Aldrich; tin(II) iodide (SnI₂, for perovskite precursor) was purchased from Tokyo Chemical Industry (TCI); tin(II) fluoride (SnF₂, 97.5%) was purchased by Alfa Aesar. All chemicals were used without any further purification. Glass substrates were cleaned in acetone and isopropyl alcohol (IPA) for 10 min by sonication. The cleaned glass substrates were treated with oxygen plasma for 10 min before any further deposition. Thin‐film perovskite deposition was done in a N₂‐filled glovebox and thin films were glass encapsulated immediately after thermal annealing (in the glovebox to avoid oxygen).

The peptides named LLC2A, LLC2B, LLC2C, LLC2D, LLC2E and LLC2F were all synthesized by Shanghai Qiangyao Biological Technology Co., Ltd., Shanghai, China. The OBOC peptide library and PDC were synthesized by the Kit Lam laboratory, UC Davis, United States. The linking molecules Fmoc-Lys (Dde)-OH and Fmoc-AEEA, which were for drug synthesis, were purchased from ChemPep Company, Palm Beach, FL, USA; amide resin was purchased from P3BioSystems Co., Ltd., Louisville, KY, USA; HCTU and 3-(2-pyridyldithio)propionic acid were purchased from Matrix Scientific Co., Ltd., Elgin, SC, USA; 6-Cl HOBt and natural and unnatural amino acids were all purchased from Chem-Impex Co., Ltd., Bensenville, IL, USA; fluorescein-labeled Cyanine5.5-NHS was purchased from LuMiprobe Co., Ltd.; 4-methylpiperidine was purchased from Alfa Aesar Co., Ltd., Ward Hill, MA, USA; DIEA, trifluoroacetic acid, anisole, DIC and other organic solvents were all purchased from Sigma-Aldrich Co., Ltd., Saint Louis, MO, USA; DM1 was purchased from BoRui Co., Ltd., SuZhou, China. FGFR2 was purchased from Sino Biological Co., Ltd., Beijing, China; anti-FGFR2 (Bek(C-17):sc-122) was acquired from Santa Cruz Blotechnology, Santa Cruz, CA, USA.

Cesium iodide (CsI, > 99.9%), formamidinium iodide (FAI, > 99.5%), methylammonium iodide (MAI, > 99.5%), lead(II) iodide (PbI₂, > 99.99%), lead(II) bromide (PbBr₂, > 99.99%), bathocuproine (BCP), and [6, 6]-phenyl-C₆₁-butyric acid methyl ester (PCBM) were purchased from Xi’an Polymer Light Technology. Tin(II) iodide (SnI₂, 99.99%), tin(II) fluoride (SnF₂, 99%), nickel(II) nitrate hexahydrate [Ni(NO₃)₂·6H₂O], 2-methoxyethanol, acetylacetone, ammonia, N,N-dimethylformamide (DMF, 99.8%), dimethyl sulfoxide (DMSO, 99.8%), isopropanol (IPA), chlorobenzene (CB), γ-butyrolactone (GBL), and anisole were obtained from Sigma-Aldrich. d-Homoserine lactone hydrochloride (D-HLH) was purchased from Macklin. Poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS, Clevios™ PVP AI 4083) was purchased from Heraues.

The following chemical reagents were used in the procedures described below for the synthesis of KIT-5 materials: Pluronic F127 (ethylene oxide and propylene oxide triblock copolymer EO₁₀₆PO₇₀EO₁₀₆, BASF, Ludwigshafen am Rhein, Germany), tetraethyl orthosilicate, TEOS (≥99%, Sigma-Aldrich, Darmstadt, Germany), 3-mercapropyltrimethoxysilane, MPTMS (95%, abcr GmbH, Karlsruhe, Germany), hydrochloric acid (37.3%, POCh, Gliwice, Poland), ethyl alcohol 96% (POCh, Gliwice, Poland), toluene (Chempur, Piekary Śląskie, Poland), and chloroform (98.5%, POCh, Gliwice, Poland). For the analysis of active acidic centres in the synthesized materials: sodium hydroxide (0.01 M, test portion, Chempur, Piekary Śląskie, Poland), sulphuric acid(VI) (0.005 M, test portion, Merck, Darmstadt, Germany) were used. In the Friedel–Crafts alkylation reaction the following materials were used: anisole (99%, Sigma-Aldrich, Darmstadt, Germany), benzyl alcohol (Ph Eur, Fluka Analytical, Darmstadt, Germany), n-decane (>94%, Merck, Darmstadt, Germany). Commercially available non-mesoporous silica (Sigma-Aldrich, Darmstadt, Germany) was used as a reference material in the heterogeneous catalytic tests, while p-toluenesulfonic acid, PTSA (≥98.5%, Sigma-Aldrich, Darmstadt, Germany) was used as a homogeneous catalyst.

NCP Block of 96 hydroxypropylmethacrylate pins and F-moc protected amino acids were obtained from Mimotopes (Clayton, Victoria, Australia). Chemicals used for synthesis and side chain deprotection like piperidine, dimethylformamide (DMF), trifluoracetic acid, diisopropylcarbodiimide (DIC) were of analytical grade, purchased from Merck Millipore (Burlington, MA, USA). Reagents like 2-mercaptoethanol, ethanedithiol, anisole, 1-hydroxybenzotriazole (HoAt), N,N-diisopropylethylamine (DIEA) and bromophenol blue were purchased from Sigma-Aldrich (Saint Louis, MO, USA).
A total of 20 FliC 15-amino acid- and 32 FliD 16-amino acid-long peptides covering predicted epitopes were synthesized. Peptides were synthesized according to standard protocol^{25 (link)} with slight changes^{6 (link),26 (link)}.