Drx 400 as

Manufactured by Bruker

Sourced in Germany

The DRX-400 AS is a nuclear magnetic resonance (NMR) spectrometer produced by Bruker. It is designed to perform high-resolution NMR analysis of chemical samples. The core function of the DRX-400 AS is to detect and analyze the magnetic properties of atomic nuclei within a sample, providing information about the chemical structure and composition of the material.

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Lab products found in correlation

Aviii hd 500, by Bruker (1 mentions) Flash ea 1112, by Thermo Fisher Scientific (1 mentions) Victor x4 2030 multilabel reader, by PerkinElmer (1 mentions)

Close spelling variants of this product

DRX-400 (185 citations)

2 protocols using drx 400 as

Synthesis and Characterization of Benzimidazolium Compounds

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Unless noted otherwise, all reagents were obtained from Sigma-Aldrich, VWR and Fluorochem and used as supplied. The purity of the synthesized compounds was proven by elemental analysis (Flash EA 1112, Thermo Quest) and differed by less than 0.5% from the predicted values. NMR spectra were recorded on a Bruker DRX-400 AS, AV III HD 500 or a AVII 600 NMR spectrometer; positive-ion ESI (electrospray ionization) mass spectra were recorded a expression^L CMS spectrometer (Advion). Complexes SBC3 (ref. 15 (link)) and Ag-1a (ref. 39 (link)) have been reported previously. Compounds 1,3-diethylbenzimidazolium iodide (1),^{40 (link)} 1,3-di(isopropyl)benzimidazolium iodide (3),^{41 (link)} 1,3-diethylbenzimidazolium chloride (1a)^{42 (link)} and 1,3-di(isopropyl)benzimidazolium chloride (3a)^{43 (link)} were reported in the literature already.

Gil-Moles M., O'Beirne C., Esarev I.V., Lippmann P., Tacke M., Cinatl J J.r., Bojkova D, & Ott I. (2023). Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2. RSC Medicinal Chemistry, 14(7), 1260-1271.

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Synthetic Protocols for Bioactive Compounds

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The reagents were purchased from Merck (Darmstadt, Germany), Thermo Fisher (Kandel, Germany), or TCI (Eschborn, Germany), and used without additional purification steps. All reactions were performed without precautions to exclude air or moisture. ¹H and ¹³C NMR were recorded on a Bruker Biospin (Germany) DRX-400 AS (Germany), AVIIIHD 500, or AVII 600. A Finnigan MAT 95 was used to record the ESI mass spectra. The elemental analyses were performed using a Flash EA 1112 (Thermo Quest CE Instruments, Egelsbach, Germany). Absorption measurements for TrxR inhibition, and antiproliferative activity were performed on a Perkin-Elmer 2030 Multilabel Reader VICTOR^TM X4 (Rodgau, Germany). The synthesis of 2a [29 (link)], 2c [30 (link)], and 3a [14 (link)] was reported. For computational chemistry, Gaussian 98 W (5.4 Rev A.9) was used with the B3LYP functional and LANL2DZ basis set [31 ].

Burmeister H., Dietze P., Preu L., Bandow J.E, & Ott I. (2021). Evaluation of Ruthenium(II) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase. Molecules, 26(14), 4282.

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