Irbesartan

Manufactured by Fujifilm

Sourced in Japan

Irbesartan is a laboratory reagent used in analytical and research applications. It is an angiotensin II receptor antagonist that can be used in various assays and experiments.

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Lab products found in correlation

Valsartan, by Tokyo Chemical Industry (2 mentions) Losartan, by Fujifilm (2 mentions) Telmisartan, by Tokyo Chemical Industry (2 mentions) Sch772984, by Selleck Chemicals (1 mentions) Compound c, by Abcam (1 mentions)

3 protocols using irbesartan

Irbesartan treatment in LATY136F mice

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LATY136F mutant mice aged 3 weeks (N = 6 LATY136 mutant mice and N = 5 WT mice) were orally administered PBS as a placebo or 50 mg/kg per day of irbesartan (Wako Pure Chemical Industries Ltd., Osaka, Japan) for three consecutive weeks, based on a previous report.15 These mice were sacrificed at 6 weeks of age.

Cui Y., Masaki K., Zhang X., Yamasaki R., Fujii T., Ogata H., Hayashida S., Yamaguchi H., Hyodo F., Eto H., Koyama S., Iinuma K., Yonekawa T., Matsushita T., Yoshida M., Yamada K., Kawano M., Malissen M., Malissen B, & Kira J. (2019). A novel model for treatment of hypertrophic pachymeningitis. Annals of Clinical and Translational Neurology, 6(3), 431-444.

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Preparation and Storage of Angiotensin II Receptor Antagonists

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Telmisartan and valsartan were purchased from Tokyo Chemical Industry Co. (Tokyo, Japan). Losartan and irbesartan were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). We prepared solutions of Telmisartan, valsartan and irbesartan by diluting with dimethyl sulfoxide (DMSO). Losartan was prepared by diluting with H₂O. The stock solutions were stored at −20°C.

Oura K., Tadokoro T., Fujihara S., Morishita A., Chiyo T., Samukawa E., Yamana Y., Fujita K., Sakamoto T., Nomura T., Yoneyama H., Kobara H., Mori H., Iwama H., Okano K., Suzuki Y, & Masaki T. (2017). Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest. Oncology Reports, 38(5), 2825-2835.

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Angiotensin II Receptor Antagonist Preparation

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Telmisartan and valsartan were purchased from Tokyo Chemical Industry Co. (Tokyo, Japan). Irbesartan and losartan were purchased from Wako Pure Chemical Industries (Osaka, Japan). Telmisartan was prepared as a 10 mM stock solution in dimethyl sulfoxide (DMSO). Irbesartan and valsartan were prepared as 100 mM stock solutions in DMSO, and losartan was prepared as a 100 mM stock solution in H₂O. The stock solutions were stored at -20°C. Compound C was purchased from Abcam (Cambridge, UK). MK-2206 was purchased from ChemScene Chemicals (Monmouth Junction, NJ, USA). SCH772984 was purchased from Selleck Chemicals (Houston, TX, USA).

Fujihara S., Morishita A., Ogawa K., Tadokoro T., Chiyo T., Kato K., Kobara H., Mori H., Iwama H, & Masaki T. (2016). The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKa/mTOR pathway in vitro and in vivo. Oncotarget, 8(5), 8536-8549.

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