Biograph sensation 16 hi rez

Manufactured by Siemens

Sourced in Germany, United States

The Biograph Sensation 16 Hi-Rez is a positron emission tomography (PET) scanner developed by Siemens. It is designed to acquire high-resolution images of the human body using advanced PET technology.

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Lab products found in correlation

Gemini tof, by Philips (1 mentions) Gemini gxl, by Philips (1 mentions)

Close spelling variants of this product

Biograph HI-REZ 16 Biograph Hi-rez Biograph Sensation 16 Sensation 16 Biograph 16

3 protocols using biograph sensation 16 hi rez

PET/CT Imaging During Radiotherapy

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For patients treated at the Centre Henri Becquerel, the per-therapeutic PET/CT was performed on a Biograph Sensation 16 Hi-Rez device (Siemens Medical Solutions, Erlangen, Germany), without time of flight system or image reconstruction algorithm incorporating point-spread function. Forty-six patients underwent their PET/CT on this device. They were unrolled in S1–3 monocentric clinical trials (39 patients), and in S4 (7 patients). As the PET/CT device corresponded to an old generation model, these patients were grouped into a database called S_old.
Patients who underwent their FDG PET/CT on a new generation of positron-emission tomograph came from S4 study. All the image reconstruction algorithms incorporated a point-spread function, while some of them used a time of flight system (ToF). They were grouped into a database called S_New (21 patients). The PET/CT models and their characteristics are listed in Appendix.
All 67 patients underwent a FDG PET/CT during the fifth week of radiation therapy. Protocols of acquisition and reconstruction followed EANM procedure guidelines [5 (link)], but they were inherent to each nuclear medicine department. On the other hand, they were the same for a given device.

Ganem J., Thureau S., Gardin I., Modzelewski R., Hapdey S, & Vera P. (2018). Delineation of lung cancer with FDG PET/CT during radiation therapy. Radiation Oncology (London, England), 13, 219.

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FDG-PET/CT Imaging Protocol: Standardized Procedure

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The FDG-PET/CT data were acquired on a Biograph^® Sensation 16 Hi-Rez device (Siemens Medical Solutions, IL, USA). Patients were required to fast for at least 6 hours before imaging. A total of 5 MBq/kg of FDG was injected after 20 min of rest. Sixty minutes later (±10 min), 6 to 8 bed positions per patient were acquired using a whole-body protocol (3 min per bed position). The PET images were reconstructed using Fourier rebinding and attenuation-weighted ordered subset expectation maximization algorithms. The images were corrected for random coincidences, scatter, and attenuation. Finally, the FDG-PET images were smoothed with a Gaussian filter (full width at half maximum = 5 mm). The reconstructed image voxel size was 4 × 4 × 2 mm³.

Desbordes P., Ruan S., Modzelewski R., Pineau P., Vauclin S., Gouel P., Michel P., Di Fiore F., Vera P, & Gardin I. (2017). Predictive value of initial FDG-PET features for treatment response and survival in esophageal cancer patients treated with chemo-radiation therapy using a random forest classifier. PLoS ONE, 12(3), e0173208.

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Standardized 18F-FDG PET/CT Imaging Protocol

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All the centers adhered to guidelines of the European Association of Nuclear Medicine for patient preparation and PET/CT acquisition. All patients were instructed to fast for at least 6 h before the injection of 4-5 MBq per kilogram of 18 F FDG, to ensure that serum glucose and endogenous serum insulin levels were low. Non-contrast-enhanced CT images were acquired before PET data acquisition. Whole-body PET was acquired sequentially using a dedicated PET/CT system. For the PET imaging, the emission data were acquired from the base of the skull to the proximal thigh with 3-3.5 min of acquisition per bed position. A Biograph Sensation 16 Hi-Rez (Siemens Medical Solution) or Gemini GXL or Gemini TOF (Philips) scanner was used by the 5 centers. All the devices used in this study followed a quality control program ensuring that the data were quantitatively correct (quarterly SUV verification). Four centers had obtained European Association of Nuclear Medicine Research Ltd. accreditation at the time of the study, and 1 was accredited according to the RTEP (Radiotherapy and PET) trial procedure (8) . The similarity of performances of the different equipment was confirmed with the analysis of the recovery curves obtained from their NEMA phantoms in terms of volume and contrast.

Cottereau A.S., Hapdey S., Chartier L., Modzelewski R., Casasnovas O., Itti E., Tilly H., Vera P., Meignan M.A, & Becker S. (2017). Baseline Total Metabolic Tumor Volume Measured with Fixed or Different Adaptive Thresholding Methods Equally Predicts Outcome in Peripheral T Cell Lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(2).

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