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Spectris solaris ep mrinjection system

Manufactured by Bayer
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Sourced in United States

The Spectris Solaris EP MRinjection system is a lab equipment product designed for sample preparation and analysis. It is a compact, self-contained unit that automates the injection of samples into an analytical instrument. The system features programmable injection parameters and can accommodate a variety of sample volumes and types.

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Lab products found in correlation

Matlab, by MathWorks (1 mentions) Magnetom avanto, by Siemens (1 mentions) Multihance, by Bracco (1 mentions) Gadovist, by Bayer (1 mentions) Magnetom biograph mmr, by Siemens (1 mentions) Biograph mmr scanner, by Siemens (1 mentions)

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Spectris Solaris EP Spectris Solaris Spectris Solaris

4 protocols using spectris solaris ep mrinjection system

1

Reproducibility Study of 13C MRI Metabolic Imaging

Cited 1 time
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The reproducibility study was performed on a Siemens Biograph mMR 3T system (Siemens
Healthineers, Erlangen, Germany), using a custom-designed 13C clamshell
transmit and dual tuned 1H/13C endorectal, receive-only coil
(RAPID Biomedical GmbH, Rimpar, Germany), alongside a MEDRAD Spectris Solaris EP MR
injection system (MEDRAD, Pennsylvania). All chemicals used in this study were
sourced from Merck (Merck KGaA, Darmstadt, Germany); Merck Life Science UK Limited):
L-LDH from rabbit muscle (SKU 10127876001), 5 ml; β-nicotinamide adenine
dinucleotide(NADH), reduced disodium salt hydrate (SKU N8129), 1 g; phosphate
buffered saline (PBS), pH 7.2, (SKU 806544), 1 L.
Data processing was performed using MATLAB (Mathworks, Massachusetts). Each
metabolite signal time course was normalised to its maximum pyruvate signal,
allowing for different data sets (n = 8) to be compared.
Quantification of the time courses was performed using some previously described methods.9 (link)
 These are further explained in the Supplementary Material 1 (Figure S2).
Chowdhury R., Papoutsaki M.V., Müller C.A., Smith L., Gong F., Bullock M., Rogers H., Mathew M., Syer T., Singh S., Retter A., Caselton L., Ryu J., Oliver-Taylor A., Golay X., Bainbridge A., Gadian D.G, & Punwani S. (2022). A reproducible dynamic phantom for sequence testing in hyperpolarised 13C-magnetic resonance. The British Journal of Radiology, 95(1134), 20210770.
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2

Liver Imaging Protocol with Gadolinium Contrast

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MRI was performed on 1.5 Tesla Magnetom Avanto magnetic resonance scanners (Siemens Medical Solutions, Malvern, PA, USA). Standard sequences included axial T1-weighted in- and out-of-phase images, fat-suppressed axial T2-weighted images (HASTE: Siemens Medical Solutions, Malvern, PA, USA), coronal T2-weighted images (HASTE), and fat-suppressed axial T1 Volumetric Interpolated Breath-hold Examination (VIBE; Siemens Medical Solutions, Malvern, PA, USA) pre- and post-contrast images with a 320 x 168 matrix, 3 mm slice thickness, NEX=1, TR=4.61 ms, TE=2.18 ms. Dynamic post-contrast images were obtained in arterial, portal venous, and 5 minute delayed phases using sample bolus triggering method. The timing of arterial phase for dynamic post-contrast images was determined based on aortic peak sample bolus timing (18-20 seconds). A 15 mL gadolinium contrast bolus (gadobenate dimeglumine, Multihance®, Bracco Diagnostics Inc., Monroe Township, NJ, USA) and 20 mL saline flush was administered via power injection (Spectris Solaris EP MR Injection System, Medrad, Warrendale, PA, USA).
Ladd L.M., Tirkes T., Tann M., Agarwal D.M., Johnson M.S., Tahir B, & Sandrasegaran K. (2016). Comparison of hepatic MDCT, MRI, and DSA to explant pathology for the detection and treatment planning of hepatocellular carcinoma. Clinical and Molecular Hepatology, 22(4), 450-457.
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3

Whole-Body PET/MRI Imaging Protocol

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Whole-body PET/MRI examinations were performed on a Magnetom Biograph mMR (Siemens Healthcare Sector, Erlangen, Germany), using lutetium oxyorthosilicate-based avalanche photodiodes (APD) for PET-acquisition. PET/MRI scans were obtained with an average delay of 102±39 min after 18F-FDG injection and a mean activity of 201±69 MBq. Whole body PET scans, covering the body from skull-base to mid-thighs, were performed with 5 to 6 bed positions and an acquisition time of 8 minutes each. PET images were reconstructed using the iterative algorithm OSEM, 3 iterations and 21 subsets, Gaussian filter with 4 mm full width at half maximum (FWHM) and a 344×344 image matrix. PET data were automatically attenuation corrected using a four-compartment-model attenuation map (µ-map) calculated from fat-only and water-only as obtained from Dixon-based sequences. Simultaneous whole-body MR imaging was performed with a dedicated mMR head and neck coil and phased-array body surface coils. The overall examination time of the PET/MR protocol for whole-body staging amounted to 35±5 min., encompassing the following sequences:
For contrast-enhanced imaging, 0.1 mmol/kg Gadobutrol (Gadovist, Bayer HealthCare, Germany), followed by a saline flush of 20 ml, was injected intravenously at 2 ml/s using an automated injector (Spectris solaris EP MR Injection System, Medrad, Germany).
Grueneisen J., Beiderwellen K., Heusch P., Buderath P., Aktas B., Gratz M., Forsting M., Lauenstein T., Ruhlmann V, & Umutlu L. (2014). Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer. PLoS ONE, 9(5), e96751.
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4

Multi-Modal Neuroimaging of Dopamine Receptor Function

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Participants completed a simultaneous PET-MR scan on a Siemens Biograph mMR scanner at the UNC Biomedical Research Imaging Center using a bolus+infusion protocol with a planned K bol of 105min [42] . PET acquisition took place for 63min. Approximately 1min after the PET scan began, a bolus injection of [ 11 C]raclopride was administered after which the infusion injection of [ 11 C]raclopride was administered using a Medrad® Spectris Solaris® EP MR Injection System (radioactivity was limited to 15mCi in total over the bolus and infusion and mass dose did not exceed 10µg (with a specific radioactivity at the bolus time of injection > 0.4 Ci/µmol)). A 6min structural T1-based MR sequence was obtained (FOV=256 mm, 1ൈ1ൈ1 mm resolution, TR=2530ms, TE=1.69ms, flip angle=7 degrees) for anatomical localization, spatial normalization of imaging data, and generation of attenuation correction maps [43] , in addition to localizer and attenuation correction scans. Then, two resting-state scans were obtained (echo planar imaging, FOV=212 mm, 3.312ൈ3.312ൈ3.3 mm resolution, TR=3000, TE=30ms, flip angle=90 degrees). Next, three task blocks were presented during which fMRI data were collected simultaneously to the ongoing PET acquisition. See Figure 1 for timing of data collection, data modelling, and participant behavior.
----------------Figure 1----------------
Zürcher N.R., Walsh E.C., Phillips R.D., Cernasov P., Tseng C.J., Dharanikota A., Smith E.P., Li Z., Kinard J.L., Bizzell J., Greene R.K., Dillon D.G., Pizzagalli D.A., Izquierdo‐Garcia D., Lalush D.S., Hooker J.M., & Dichter G.S. (2020). A Simultaneous [11C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation of Striatal Dopamine Binding in Autism.
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