Oxymorphone

Manufactured by Cerilliant

Sourced in United States

Oxymorphone is a chemical compound used as a laboratory standard. It is a pharmaceutical opioid analgesic used for research and analytical purposes. The core function of oxymorphone is to serve as a reference material for analytical testing and research applications.

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Oxymorphone-d3 (2 citations) Oxymorphone-3β-D-glucuronide-d3 (OMG-d3), (2 citations)

4 protocols using oxymorphone

Quantification of Opioids and Cannabinoids in Wastewater

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Morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, Δ⁹-tetrahydrocannabinol (THC) and its metabolites 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) and THCCOOH-glucuronide were purchased from Cerilliant (Round Rock, TX, USA). The deuterated analogs THC-d₃, THCCOOH-d₃, THCCOOH-glucuronide-d₃, Morphine-d₃, oxycodone-d₆, hydrocodone-d₆, oxymorphone-d₃ and hydromorphone-d₆ were also purchased from Cerilliant. Strata XC 33 µm polymeric strong cation exchange cartridges of 3 mL/60 mg for calibrators and 6 mL/200 mg for quality control (QC) and authentic wastewater samples were purchased from Phenomenex (Torrance, CA, USA). Ultra-high performance liquid chromatography (UHPLC) grade methanol, dichloromethane and ammonium hydroxide were purchased from Pharmco-Aaper (Brookfield, CT). Isopropanol, liquid chromatography mass spectrometry grade acetonitrile, and Whatman glass microfiber filters (outside diameter 4.7 cm, particle retention 1.6 μm, and thickness 0.26 mm) were from Thermo Fisher Scientific (Waltham, MA, USA).

Jacox A., Wetzel J., Cheng S.Y, & Concheiro M. (2017). Quantitative analysis of opioids and cannabinoids in wastewater samples. Forensic sciences research, 2(1), 18-25.

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Opioid Receptor Binding Assay

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Morphine, hydromorphone, oxymorphone, butorphanol, levorphanol, nalbuphine, nalorphine, naltrexone, 6β-naltrexol, buprenorphine, pentazocine, and naloxone, were purchased from Cerilliant. Adenosine 5’-triphosphate (ATP), sodium dodecyl sulfate (SDS), dithiothreitol (DTT), dimethyl sulfoxide (DMSO), 3-(N-morpholino)propanesulfonic acid (Mops), Trizma base (Tris), isopropyl-β-D-thiogalactopyranoside (IPTG), and silica gel thin-layer chromatography (TLC) plates were from Sigma Chemical Company. Polyethyleneimine (PEI) cellulose TLC plates were from Brinkmann. Ecolume scintillation cocktail was purchased from MP Biomedical. Carrier-free sodium [³⁵S]sulfate was from PerkinElmer. HepG2 human hepatoma cell line (ATCC HB-8065) was obtained from American Type Culture Collection. Pooled human lung S9 fraction, liver cytosol, small intestine (duodenum and jejunum) S9 fraction, and kidney S9 fraction were purchased from XenoTech, LLC. All other chemicals were of the highest grade commercially available.

Kurogi K., Chepak A., Hanrahan M.T., Liu M.Y., Sakakibara Y., Suiko M, & Liu M.C. (2014). Sulfation of opioid drugs by human cytosolic sulfotransferases: Metabolic labeling study and enzymatic analysis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 40-48.

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Certified Reference Standards for Drugs

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Certified reference standards of 6-monoacetylmorphine, alprazolam, amphetamine, buprenorphine, benzoylecgonine, carisoprodol, chlordiazepoxide, clonazepam, cocaine, codeine, cotinine, dihydrocodeine, diazepam, EDDP, fentanyl, flurazepam, hydrocodone, hydromorphone, lorazepam, MDA, MDEA, MDMA, methamphetamine, meperidine, morphine, methylphenidate, methadone, naloxone, norbuprenorphine, nicotine, nordiazepam, norfentanyl, noroxycodone, alpha-hydroxyalprazolam, oxazepam, oxycodone, oxymorphone, tapentadol, temazepam, ll-nor-9-Carboxy-Δ9-THC, and cis-tramadol were purchased, each at a concentration of 1 mg/mL, from Cerilliant Corporation (Round Rock, TX). Isotopically labeled internal standards (IS) morphine-D3, codeine- D6, hydrocodone-D3, 6-monoacetylmorphine-D6, hydromorphone-D6, oxymorphone-D3, noroxycodone-D3, and naloxone-D5 were purchased, each at a concentration of 100 μg/mL, from Cerilliant Corporation (Round Rock, TX). Drug-free urine was obtained from Bio-Rad Laboratories (Irvine, CA). High-performance liquid chromatography (HPLC) grade water, methanol, and formic acid were purchased from Fisher Scientific (Pittsburgh, PA) and ammonium formate was purchased from Sigma Aldrich (St. Louis, MO).

Pablo A., Breaud A.R, & Clarke W. (2019). Automated Analysis of Dried Urine Spot (DUS) Samples for Toxicology Screening. Clinical biochemistry, 75, 70-77.

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Comprehensive Analytical Reference Standards

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Certified reference materials of amitriptyline, bupropion, citalopram, desipramine, desmethylcitalopram, duloxetine, fluoxetine, imipramine, mirtazapine, nortriptyline, paroxetine, sertraline and trazodone were purchased from LGC Standards (Teddington, London, UK); certified reference materials of clomipramine, desmethylvenlafaxine, doxepin, hydroxybupropion, norfluoxetine, norsertraline, trimipramine, venlafaxine, 7-amino clonazepam, 7-amino flu nitrazepam, alprazolam, bromazepam, clonazepam, diazepam, flu nitrazepam, lorazepam, midazolam, nitrazepam, nordiazepam, oxazepam, temazepam, zolpidem, 6-monoacetyl morphine, N-desmethyltramadol, buprenorphine, codeine, fentanyl, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, tramadol, bupropion-d 9 , citalopram-d 6 , clonazepam-d 4 , codeine-d 3 , diazepam-d 5 , duloxetine-d 3 and morphine-d 3 from Cerilliant (Round Rock, TX, USA); methanol, acetonitrile, ammonium formate and formic acid from Merck (Darmstadt, Germany); ultrapure deionized water was purified by Milli-Q from Millipore (Billerica, MA, USA). All solvents used in the extraction procedure were HPLC grade. Quantisal™ oral fluid collection devices and elution buffer were purchased from Immunalysis (Pomona, CA, USA).

Arantes A.C.F., Cunha K.F.d., Cardoso M.S., Oliveira K.D., & Costa J.L. (2020). Development and validation of quantitative analytical method for 50 drugs of antidepressants, benzodiazepines and opioids in oral fluid samples by liquid chromatography–tandem mass spectrometry. Forensic Toxicology, 39(1), 179-197.

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