Il 11rα1

Manufactured by Santa Cruz Biotechnology

Sourced in United States

IL-11Rα1 is an extracellular protein that functions as a receptor for the cytokine interleukin-11. It is involved in the regulation of various cellular processes, including cell growth, differentiation, and immune response.

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Lab products found in correlation

Tgf βrii, by Santa Cruz Biotechnology (1 mentions) F4 80, by Santa Cruz Biotechnology (1 mentions) Sftpc, by Abcam (1 mentions) Il 11, by Santa Cruz Biotechnology (1 mentions) Ertr7, by Santa Cruz Biotechnology (1 mentions) Tgf β1, by Abcam (1 mentions) Vimentin, by Cell Signaling Technology (1 mentions) Ab62623, by Abcam (1 mentions) Ab64715, by Abcam (1 mentions) Ab28052, by Abcam (1 mentions) Vectastain abc hrp kit, by Vector Laboratories (1 mentions) Interleukin 6 (il 6), by Santa Cruz Biotechnology (1 mentions) Ab9722, by Abcam (1 mentions) Ab211542, by Abcam (1 mentions)

2 protocols using il 11rα1

Multimarker Immunofluorescence Staining

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Primary antibodies against CD3 (sc-20047, Santa Cruz Biotechnology Inc.), F4/80 (sc-377009, Santa Cruz Biotechnology Inc.), IL-11Rα1 (sc-130920, Santa Cruz Biotechnology Inc.), SFTPC (ab211326, Abcam), TGF-β1 (ab64715, Abcam), IL-11 (sc-133063, Santa Cruz Biotechnology Inc.), vimentin (#5741, Cell Signaling Technology), p53 (#2524, Cell Signaling Technology), p16 (#MA5-17142, Invitrogen Inc.), fibroblast marker (ER-TR7) (sc-73355, Santa Cruz Biotechnology Inc.), and TGF-β RII (sc-17792, Santa Cruz Biotechnology Inc.) and affinity-purified Alexa Fluor 488-conjugated and 594-conjugated secondary antibodies (Life Technologies Corporation, USA) were used. Details are provided in Supporting Information 3.

Chen H., Chen H., Liang J., Gu X., Zhou J., Xie C., Lv X., Wang R., Li Q., Mao Z., Sun H., Zuo G., Miao D, & Jin J. (2020). TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency. Experimental & Molecular Medicine, 52(1), 130-151.

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Immunohistochemical Analysis of Cellular Markers

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Immunohistochemical staining was performed as previously described. Primary antibodies against p16 (ab211542; Abcam), p53 (sc‐126; Santa Cruz Biotechnology), acetyl‐histone H3 (Lys9/Lys14; #9677; Cell Signaling Technology), 8‐OHdG (ab62623; Abcam), IL‐1β (ab9722; Abcam), CD3e (sc‐20,047; Santa Cruz Biotechnology), IL‐6 (sc‐1265; Santa Cruz Biotechnology), TNF‐α (sc‐52,746; Santa Cruz Biotechnology), α‐SMA (ab28052; Abcam), Collagen 1 (#1310‐08; Southern Biotech), TGF‐β1 (ab64715; Abcam), and IL‐11 (sc‐133,063; Santa Cruz Biotechnology), and IL‐11Rα1 (sc‐130,920; Santa Cruz Biotechnology). After washing, the sections were incubated with secondary antibody (biotinylated IgG; Sigma‐Aldrich), washed, and processed using Vectastain ABC‐HRP kits (Vector Laboratories).

Zhou J., Chen H., Wang Q., Chen S., Wang R., Wang Z., Yang C., Chen A., Zhao J., Zhou Z., Mao Z., Zuo G., Miao D, & Jin J. (2022). Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription. Aging Cell, 21(8), e13680.

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